Magnesium in tumoral tissues, in the muscle and serum of subjects suffering from neoplasia

Ca2+‐dependent interactions between lipids and the tumor‐targeting peptide pHLIP

“…Unfortunately, our knowledge of the basic mechanism of conformational switching in membrane systems is often lacking, impeding our ability to predict protein‐lipid interactions and the resulting conformations under physiological conditions. Specifically, the role of lipid composition and divalent cations in modulating these interactions remains under‐explored, despite the mounting evidence of their physiological importance in triggering (together with [H + ] differences) functionally relevant conformational changes 9–16 . Our ability to target or manipulate these processes can therefore be beneficial for human health.…”

“…Specifically, the role of lipid composition and divalent cations in modulating these interactions remains under-explored, despite the mounting evidence of their physiological importance in triggering (together with [H + ] differences) functionally relevant conformational changes. [9][10][11][12][13][14][15][16] Our ability to target or manipulate these processes can therefore be beneficial for human health.…”

Levels of chemical element contents in thyroid as potential biomarkers for cancer diagnosis (a preliminary study)

“…If so, significant reduction in Mg content can be associate with TC, because malignant transformation is accompanied by a loss of thyroid-specific functional features. However, it is well known that malignant tumors usually have higher Mg levels than normal tissues [102][103][104][105][106][107] , possibly caused by the "retention" of Mg by the tumor [108] , as a result of the high Mg requirement of growing cells. In addition, cultured proliferating cells have long been known to contain more magnesium than quiescent cells, and experimental conditions that decreased magnesium availability affected cell proliferation rate [109] .…”

Twenty Chemical Element Contents in Normal and Cancerous Thyroid

“…If so, significant reduction in Mg content cam be associate with TC, because malignant transformation is accompanied by a loss of thyroid-specific functional features. However, it is well known that malignant tumors have an usually higher Mg levels than do normal tissues [105][106][107][108][109][110], possibly caused by the "retention" of Mg by the tumor [111], as a result of the high Mg requirement of growing cells. In addition, cultured proliferating cells have long been known to contain more magnesium than quiescent cells, and experimental conditions that decreased magnesium availability affected cell proliferation rate [112].…”