Twenty Chemical Element Contents in Normal and Cancerous Thyroid

Zaichick, Vladimir; Zaichick, Sofia

doi:10.15226/ijhbd/3/2/00121

Cited by 17 publications

(17 citation statements)

References 62 publications

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“…Instead, the significant presence of Bi in thyroid has not been reported elsewhere. Recently, Bi was detected in thyroid of 105 healthy subjects with increasing concentration in the same tissue of patients affected by malignant thyroid tumors [58]. We recovered significant concentrations of Bi in brain and testis (Table 1), suggesting that the element crossed two types of the tightest tissue barriers in mammals, i.e.…”

Section: Tissue Distributionmentioning

confidence: 70%

Metallobiochemistry of ultratrace levels of bismuth in the rat II. Interaction of 205+206Bi3+ with tissue, intracellular and molecular components

Sabbioni

Groppi

Gioacchino

et al. 2021

Journal of Trace Elements in Medicine and Biology

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Background: Knowledge on Bi metabolism in laboratory animals refers to studies at "extreme" exposures, i.e. pharmacologically relevant high-doses (mg/kg b.w.) in relation to its medical use, or infinitesimal doses (pg/kg b.w.) concerning radiobiology protection and radiotherapeutic purposes. There are no specific studies on metabolic patterns of environmental exposure doses (ultratrace level, µg/kg b.w.), becoming in this context Bi a "heavy metal fallen into oblivion". We previously reported the results of the metabolic fate of ultratrace levels of Bi in the blood of rats [1]. In reference to the same study here we report the results of the retention and tissue binding of Bi with intracellular and molecular components.Methods: Animals were intraperitoneally injected with 0.8 µg Bi/kg b.w. as 205+206 Bi(NO)3, alone or in combination with 59 Fe for the radiolabeling of iron proteins. The use of 205+206 Bi radiotracer allowed the determination of Bi down to pg/fg in biological fluids, tissues, subcellular fractions, and biochemical components isolated by differential centrifugation, size exclusion chromatography, solvent extraction, precipitation, immunoprecipitation and dialysis.Main findings: At 24h post injection the kidney contained by far the highest Bi concentration (10 ng/g wt.w.) followed by the thymus, spleen, liver, thyroid, trachea, femur, lung, adrenal gland, stomach, duodenum and pancreas (0.1 to 1.3 ng/g wt.w.). Brain and testis showed smaller but consistently significant concentrations of the element (0.03 ng/g wt.w). Urine was the predominant route of excretion. Intracellularly, liver, kidney, spleen, testis and brain cytosols displayed the highest percentages (35% to 58%) of Bi of homogenates. Liver and testis nuclei were the organelles with the highest Bi content (24% and 27%). However, when the recovered Bi of the liver was recorded as percent of total recovered Bi divided by percent of total recovered protein the lysosomes showed the highest relative specific activity than in other fractions. In the brain subcellular fractions Bi was incorporated by neuro-structures with the protein and not lipidic fraction of the myelin retaining 18% of Bi of the total homogenate. After the liver intra-subcellular fractionation: (i) 65% of the nuclear Bi was associated with the protein fraction of the nuclear membranes and 35% with the bulk chromatin bound to non-histone and DNA fractions; (ii) about 50% of the mitochondrial Bi was associated with inner and outer membranes being the other half recovered in the intramitochondrial matrix; (iii) in microsomes Bi showed a high affinity (close to 90%) for the membranous components (rough and smooth membranes); (iv) In the liver cytosol three pools of Bi-binding proteins (molecular size > 300 kDa, 70 kDa and 10 kDa) were observed with ferritin and metallothionein-like protein identified as Bi-binding biomolecules. Three similar protein pools were also observed in the kidney cytosol. However, the amount of Bi, calculated in percent of the total cytosolic Bi, were sign...

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Section: Tissue Distributionmentioning

confidence: 70%

Metallobiochemistry of ultratrace levels of bismuth in the rat II. Interaction of 205+206Bi3+ with tissue, intracellular and molecular components

Sabbioni

Groppi

Gioacchino

et al. 2021

Journal of Trace Elements in Medicine and Biology

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“…While the selenium (Se) has an effect to prevent for development of cancer cells according to a certain mechanism. Selenium (Se) helps for protection and against chromosome injury which may be caused to cancer 33 . For this reason, Zn and Se are always to have a correlation.…”

Section: Discussionmentioning

confidence: 99%

Determination of the concentration of Fe, Se and Zn elements in nails of Vietnamese women with breast cancer using k0-INAA method

et al. 2020

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Introduction: Breast cancer is the most common type of cancer resulting in death. Trace elements of Fe, Se and Zn can play a key role in the onset and prevention of breast cancer. Trace elements in the fingernails may be used as bioindicators for breast cancer diagnosis. The purpose of this work is to determine the concentrations of Fe, Se, and Zn in the fingernails of women with breast cancer and healthy women, which used to find the difference and correlation of these elements in the fingernail. Methods: This research was approved by the Ethics Committee of Dong Nai General Hospital. The fingernail collected from 29 women with breast cancer and 30 healthy women, who are the same age and living in Dong Nai province, Vietnam. The concentrations of Fe, Se, and Zn in the fingernails were determined using the k0-INAA method. The analytical data were evaluated using some statistical analysis for the correlation of trace elements in the fingernails of both groups. Results: As a result, the mean concentrations of Fe, Se and Zn in fingernails of women with breast cancer were 102.87 ug/g, 0.75 ug/g and 65.49 ug/g, respectively, while those of healthy women were 69.74 ug/g, 0.78 ug/g and 107.75 ug/g. The assessment of these elements in fingernails for both two sample groups, including t-test and correlation coefficients, was also carried out in this study. As a result, the significant difference (p < 0.05) was found for the Fe and Zn in fingernails of women with breast cancer, while those of Se was not found. The correlation between Se and Zn was found in both groups. The correlation between Fe and Zn was found in fingernails of healthy women, but it disappears in the women with breast cancer. Conclusions: From our finding, it can be concluded that Fe and Zn significantly associated with the risk of breast cancer, while Se is not associated.

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“…After that, variations of ChE content with age in the thyroid of males and females were studied and age-and gender-dependence of some ChE was observed [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] . Furthermore, a significant difference between some ChE contents in normal and cancerous thyroid was demonstrated [42][43][44][45][46][47] . So far, the pathogenesis of NG has to be considered as multifactorial.…”

Section: Introductionmentioning

confidence: 94%

Comparison of Levels of Twenty Chemical Elements in Normal Thyroid Tissue and Hypertrophic Thyroid Tissue

Zaichick

2021

Univ J Pharm Res

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Background: Goiter can appear as a palpable or visible enlargement of the thyroid gland at the base of the neck. If the goiter is accompanied by hypothyroidism or hyperthyroidism, it may be accompanied by symptoms of the underlying disorder, and nodular goiter (NG) is a health problem of international importance. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of twenty chemical elements (ChE) Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn , Na, P, S, Si, Sr, V, and Zn are present in the goitrous transformed thyroid. Methods: Thyroid tissue level of twenty ChE was prospectively evaluated in 46 patients with NG and 105 healthy populations. The measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma atomic emission spectrometry, respectively. Tissue samples were divided into two parts. One was used for morphological study while the other was for ChE analysis. Results: It was found that contents of Al, B, Br, Cl, Cu, Fe, Li, Mg, Mn, Na, P, S, Si, V, and Zn are significantly higher while the I levels are lower in NG than in normal tissues. Conclusion: There are considerable changes in ChE contents in goitrous tissue of thyroid. Thus, it is reasonable to assume that the levels of these ChE in thyroid tissue can be used as NG markers. However, this topic needs additional studies. Peer Review History: Received: 19 July 2021; Revised: 11 August; Accepted: 4 September, Available online: 15 September 2021 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng Similar Articles: VITAMIN A, RETINOIC ACID AND TAMIBAROTENE, A FRONT TOWARD ITS ADVANCES: A REVIEW

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Twenty Chemical Element Contents in Normal and Cancerous Thyroid

Abstract: Thyroid cancer is an internationally important health problem. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of Ag,

Cited by 17 publications

References 62 publications

Metallobiochemistry of ultratrace levels of bismuth in the rat II. Interaction of 205+206Bi3+ with tissue, intracellular and molecular components

Metallobiochemistry of ultratrace levels of bismuth in the rat II. Interaction of 205+206Bi3+ with tissue, intracellular and molecular components

Determination of the concentration of Fe, Se and Zn elements in nails of Vietnamese women with breast cancer using k0-INAA method

Comparison of Levels of Twenty Chemical Elements in Normal Thyroid Tissue and Hypertrophic Thyroid Tissue

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