Magnesium in the gynecological practice: a literature review

Abstract

A growing amount of evidence suggests that magnesium deficiency may play an important role in several clinical conditions concerning women health such as premenstrual syndrome, dysmenorrhea, and postmenopausal symptoms. A number of studies highlighted a positive correlation between magnesium administration and relief or prevention of these symptoms, thus suggesting that magnesium supplementation may represent a viable treatment for these conditions. Despite this amount of evidence describing the efficacy of magnesium, few and un-systematize data are available about the pharmacological mechanism of this ion for these conditions. Herein, we review and systematize the available evidence about the use of oral magnesium supplementation in several gynecological conditions and discuss the pharmacological mechanisms that characterize these interventions. The picture that emerges indicates that magnesium supplementation is effective in the prevention of dysmenorrhea, premenstrual syndrome, and menstrual migraine and in the prevention of climacteric symptoms.

The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review

“…Whereas, longer supplementation trials (~7 weeks) can elicit training-induced adaptive responses in young untrained populations [103]—whether this would be reflected in well-trained athletic populations is yet to be established. Furthermore, Mg (300 mg·day −1 over 12 weeks) may improve markers of functional performance in older populations and may be a consideration to maintain functional capacity throughout aging, but may require an even longer treatment period [127]. Lastly, there is currently no evidence to support a benefit of Mg supplementation to improve endurance performance-related outcomes, despite a logical biological potential [115].…”

Has Menstruation Disappeared? Functional Hypothalamic Amenorrhea—What Is This Story about?

“…However, in the event of a magnesium deficit, it is worth considering supplementation. In particular, magnesium supplementation appears to be beneficial for women with menstrual disorders, not only those with functional disorders [ 71 ]. An adequate supply of magnesium can have a positive effect on a person’s mood, facilitate adaptation to stressful conditions, and reduce irritability.…”

Response of Vitamin D after Magnesium Intervention in a Postmenopausal Population from the Province of Granada, Spain

“…Magnesium supplementation may offer benefits in this regard [7,8]. The inclusion of Mg supplementation in postmenopausal women in the event of deficiency has been suggested by a number of authors, as it seems to improve postmenopausal symptoms, avoiding long-term systemic consequences [9][10][11]. In recent years, the interest in vitamin D has increased, due to the high prevalence of vitamin D deficiency worldwide [12].…”