Magnesium for the prevention and treatment of cardiovascular disease

DiNicolantonio, James J.; Liu, Jing; O’Keefe, James H.

doi:10.1136/openhrt-2018-000775

Cited by 86 publications

(94 citation statements)

References 98 publications

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“…As previously described by our group, these data presented here could exhibit an important matter on the management of the cardiovascular disorders also, since it was previously showed, by authors such Rosique-Esteban [27], Efstratiadis [28] and Dinicolantonio [29] that Magnesium will descrease the risk for ischemic heart disease and coronary heart disease, diminishing also other factors such diabetes, hypertension, metabolic syndrome [27][28][29].…”

Section: Resultssupporting

confidence: 67%

An Original Study on the Correlations Between Magnesium and Depression and Their Cardiovascular Relevance

2019

Rev.Chim.

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With magnesium being an essential element in the human body, we are proposing here an original study on the correlations between magnesium and depression and their cardiovascular relevance in this context, by the usage of the experimental forced swim test. Thus, the data we are presented here could have an increased relevance in the management of these disorders, and in the further understanding of the biochemical magnesium supplementation. Keywords: magnesium, depression, oxidative stress, cardiovascular

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Section: Resultssupporting

confidence: 67%

An Original Study on the Correlations Between Magnesium and Depression and Their Cardiovascular Relevance

2019

Rev.Chim.

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“…Previous evidence suggested that the enhancement of antioxidant status and alleviating of inflammatory markers potentially improve endothelial function and blood pressure . The ability of magnesium to diminish oxidative stress and inflammation is due to the activation of antioxidant enzymes, the enhancement of endothelial nitric oxide bioavailability and inhibiting the activity of oxidant enzymes such as myeloproxidase and nicotinamide adenine dinucleotide phosphate oxidase . Vitamin E plays an important role in the scavenging free radicals and by which functions as direct antioxidative agent and protects lipid from peroxidation.…”

Section: Discussionmentioning

confidence: 99%

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Afzali

Kashi

Momen‐Heravi

et al. 2019

Wound Repair Regeneration

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This study was carried out to determine the effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250 mg magnesium oxide plus 400 IU vitamin E (n = 29) or placebo per day (n = 28) for 12 weeks. Compared with the placebo, taking magnesium plus vitamin E supplements reduced ulcer length (β [difference in the mean of outcomes measures between treatment groups] −0.56 cm; 95% CI, −0.92, −0.20; p = 0.003), width (β −0.35 cm; 95% CI, −0.64, −0.05; p = 0.02) and depth (β −0.18 cm; 95% CI, −0.33, −0.02; p = 0.02). In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −13.41 mg/dL; 95% CI, −20.96, −5.86; p = 0.001), insulin (β −1.45 μIU/ml; 95% CI, −2.37, −0.52; p = 0.003), insulin resistance (β −0.60; 95% CI, −0.99, −0.20; p = 0.003) and HbA1c (β −0.32%; 95% CI, −0.48, −0.16; p < 0.003), and a significant elevation in insulin sensitivity (β 0.007; 95% CI, 0.003, 0.01; p < 0.001) compared with the placebo. Additionally, compared with the placebo, taking magnesium plus vitamin E supplements decreased triglycerides (β −10.08 mg/dL; 95% CI, −19.70, −0.46; p = 0.04), LDL-cholesterol (β −5.88 mg/dL; 95% CI, −11.42, −0.34; p = 0.03), high sensitivity C-reactive protein (hs-CRP) (β −3.42 mg/L; 95% CI, −4.44, −2.41; p < 0.001) and malondialdehyde (MDA) (β −0.30 μmol/L; 95% CI, −0.45, −0.15; p < 0.001), and increased HDL-cholesterol (β 2.62 mg/dL; 95% CI, 0.60, 4.63; p = 0.01) and total antioxidant capacity (TAC) levels (β 53.61 mmol/L; 95% CI, 4.65, 102.57; p = 0.03). Overall, magnesium and vitamin E co-supplementation for 12 weeks to patients with DFU had beneficial effects on ulcer size, glycemic control, triglycerides, LDL-and HDL-cholesterol, hs-CRP, TAC, and MDA levels.The diabetic foot ulcer (DFU) is a chronic consequence of diabetes mellitus which mainly caused by neuropathy, different grades of ischemia, and infection that coincide with poor glycemic control and diminished neutrophil function. 1 The mortality rate among diabetic patients with DFU is higher than twofold compared with nonulcer patients. 2 Based on the previous evidence, the effective management of diabetes and timely treatment of foot ulcer are implicated for decrease the morbidity and mortality of DFU. 3 The nutritional status of diabetic patients correlates with the severity of ulcer and play an important role in the reversing of wound risk. 4 According to the prior studies, the alternation of magnesium metabolism is a common feature in diabetic patients which interference with glycemic control and contributes to impaired insulin sensitivity and chronic inflammatory status. 5In addition, observational evidence shown that there is an inverse association between magnesium levels and the occurrence of foot ulcers, nephropathy and retinopathy. 6 Similarly, it is repo...

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“…In this way, it was previously showed for example in a complex systematic review from 2018 by Nuria et al [33] group that magnesium supplementation is generally associated with a decreased risk of another related major cardiovascular risk factors such as diabetes, hypertension, metabolic syndrome and even stroke, while on the other side very high levels of circulating magnesium can be generally associated with a decreased risk of ischemic heart disease and coronary heart disease. Moreover similar individual studies from 2006 [34] or more recent ones [35] suggested a positive effect in general for the magnesium supplementation vs. cardiovascular effects context.…”

Section: Resultsmentioning

confidence: 62%

Does Magnesium Deficient Diet and its Associated Metabolic Dysfunctions Induces Anxiety-like Symptoms. Further cardiovascular relevance

Stătescu¹,

Honceriu²,

Truş³

2019

Rev. Chim.

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Zinc ions are considered to be one of the most abundant trace elements in the human body. Among many important functions, zinc ions regulate the function of numerous structural, transcriptional and enzymatic proteins that play important roles in the correct function of the central nervous system. Thus, in the present work we were interested in determining some preliminary relevance for the possible effect of acute zinc administration on the anxiety-like behavior. Our initial results described here are showing interesting biotechnological relevance for zinc in this anxiety-related context and also further theoretical developing on this area considering oxidative stress related mechanisms. Moreover, the cardiovascular relevance in both contexts of magnesium vs. cardiovascular effects or anxiety and its relations with the cardiovascular system are presented.

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Magnesium for the prevention and treatment of cardiovascular disease

Cited by 86 publications

References 98 publications

An Original Study on the Correlations Between Magnesium and Depression and Their Cardiovascular Relevance

An Original Study on the Correlations Between Magnesium and Depression and Their Cardiovascular Relevance

The effects of magnesium and vitamin E co‐supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double‐blind, placebo‐controlled trial

Does Magnesium Deficient Diet and its Associated Metabolic Dysfunctions Induces Anxiety-like Symptoms. Further cardiovascular relevance

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