Magnesium Doped Hydroxyapatite-Based Coatings Obtained by Pulsed Galvanostatic Electrochemical Deposition with Adjustable Electrochemical Behavior

Vrânceanu, Diana Maria; Ionescu, Ionut Cornel; Ungureanu, Elena; Cojocaru, Mihai Ovidiu; Vlădescu, Alina; Cotruț, Cosmin Mihai

doi:10.3390/coatings10080727

Cited by 31 publications

(30 citation statements)

References 64 publications

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“…The electrodeposition was controlled using a multichannel Potentiostat/Galvanostat (Parstat MC, Princeton Applied Research-Ametek, Oak Ridge, TN, USA) operating in pulsed galvanostatic mode. One pulse consisted of an activation stage (i ON = −0.85 mA/cm 2 for 1 s), followed by a relaxation stage (i OFF = 0 mA/cm 2 for 1 s) [42]. In total, 1200 pulses were applied.…”

Section: Coating Depositionmentioning

confidence: 99%

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

et al. 2022

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The current research aim is to biofunctionalize pure titanium (Ti, grade IV) substrate with titania nanotubes and Zn doped hydroxyapatite-based coatings by applying a duplex electrochemical treatment, and to evaluate the influence of Zn content on the physico-chemical properties of hydroxyapatite (HAp). The obtained nanostructured surfaces were covered with HAp-based coatings doped with Zn in different concentrations by electrochemical deposition in pulsed galvanostatic mode. The obtained surfaces were characterized in terms of morphology, elemental and phasic composition, chemical bonds, roughness, and adhesion. The nanostructured surface consisted of titania nanotubes (NT), aligned, vertically oriented, and hollow, with an inner diameter of ~70 nm. X-Ray Diffraction (XRD) analysis showed that the nanostructured surface consists of an anatase phase and some rutile peaks as a secondary phase. The morphology of all coatings consisted of ribbon like-crystals, and by increasing the Zn content the coating became denser due to the decrement of the crystals’ dimensions. The elemental and phase compositions evidenced that HAp was successfully doped with Zn through the pulsed galvanostatic method on the Ti nanostructured surfaces. Fourier Transform Infrared spectroscopy (FTIR) and XRD analysis confirmed the presence of HAp in all coatings, while the adhesion test showed that the addition of a high quantity leads to some delamination. Based on the obtained results, it can be said that the addition of Zn enhances the properties of HAp, and through proper experimental design, the concentration of Zn can be modulated to achieve coatings with tunable features.

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Section: Coating Depositionmentioning

confidence: 99%

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

et al. 2022

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“…The protection efficiency (P e ) was calculated taking into account the corrosion current values of the coated samples and the uncoated MgCa1 68,69 with the following formula The results show that by Zn and Ga addition into CaP composition, the protection efficacy was increased, reaching a value of P e = 99.7%, the highest among coated variants, in the case of MgCa1/(CaP+Ga) (Figure 4C).…”

Section: Resultsmentioning

confidence: 99%

“…The protection efficiency ( P e ) was calculated taking into account the corrosion current values of the coated samples and the uncoated MgCa1 , with the following formula …”

Section: Resultsmentioning

confidence: 99%

Corrosion Resistance and Cytocompatibility of Magnesium–Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings

Tamay

Gokyer

Schmidt

et al. 2021

ACS Appl. Mater. Interfaces

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In orthopedic surgery, metals are preferred to support or treat damaged bones due to their high mechanical strength. However, the necessity for a second surgery for implant removal after healing creates problems. Therefore, biodegradable metals, especially magnesium (Mg), gained importance, although their extreme susceptibility to galvanic corrosion limits their applications. The focus of this study was to control the corrosion of Mg and enhance its biocompatibility. For this purpose, surfaces of magnesium−calcium (MgCa1) alloys were modified with calcium phosphate (CaP) or CaP doped with zinc (Zn) or gallium (Ga) via microarc oxidation. The effects of surface modifications on physical, chemical, and mechanical properties and corrosion resistance of the alloys were studied using surface profilometry, goniometry, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), nanoindentation, and electrochemical impedance spectroscopy (EIS). The coating thickness was about 5−8 μm, with grain sizes of 43.1 nm for CaP coating and 28.2 and 58.1 nm for Zn-and Ga-doped coatings, respectively. According to EIS measurements, the capacitive response (Y c ) decreased from 11.29 to 8.72 and 0.15 Ω −1 cm −2 s n upon doping with Zn and Ga, respectively. The E corr value, which was −1933 mV for CaP-coated samples, was found significantly electropositive at −275 mV for Ga-doped ones. All samples were cytocompatible according to indirect tests. In vitro culture with Saos-2 cells led to changes in the surface compositions of the alloys. The numbers of cells attached to the Zn-doped (2.6 × 10 4 cells/cm 2 ) and Ga-doped (6.3 × 10 4 cells/cm 2 ) coatings were higher than that on the surface of the undoped coating (1.0 × 10 3 cells/cm 2 ). Decreased corrosivity and enhanced cell affinity of the modified MgCa alloys (CaP coated and Zn and Ga doped, with Ga-doped ones having the greatest positive effect) make them novel and promising candidates as biodegradable metallic implant materials for the treatment of bone damages and other orthopedic applications.

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“…Doping the HA coatings with Mg changed the properties. They facilitated the control of the dissolution rate of the HA coatings ( Vranceanu et al, 2020 ). Our previous research showed that the duration of ED of 20 min for the fabrication of HA coatings on 3D printed Ti scaffolds can promote cell viability, proliferation and osteogenic gene expression of MC3T3-E1 ( Zhu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Plasma Spray vs. Electrochemical Deposition: Toward a Better Osteogenic Effect of Hydroxyapatite Coatings on 3D-Printed Titanium Scaffolds

Sun

Zhang

Luo

et al. 2021

Front. Bioeng. Biotechnol.

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Surface modification of three-dimensional (3D)-printed titanium (Ti) scaffolds with hydroxyapatite (HA) has been a research hotspot in biomedical engineering. However, unlike HA coatings on a plain surface, 3D-printed Ti scaffolds have inherent porous structures that influence the characteristics of HA coatings and osteointegration. In the present study, HA coatings were successfully fabricated on 3D-printed Ti scaffolds using plasma spray and electrochemical deposition, named plasma sprayed HA (PSHA) and electrochemically deposited HA (EDHA), respectively. Compared to EDHA scaffolds, HA coatings on PSHA scaffolds were smooth and continuous. In vitro cell studies confirmed that PSHA scaffolds have better potential to promote bone mesenchymal stem cell adhesion, proliferation, and osteogenic differentiation than EDHA scaffolds in the early and late stages. Moreover, in vivo studies showed that PSHA scaffolds were endowed with superior bone repair capacity. Although the EDHA technology is simpler and more controllable, its limitation due to the crystalline and HA structures needs to be improved in the future. Thus, we believe that plasma spray is a better choice for fabricating HA coatings on implanted scaffolds, which may become a promising method for treating bone defects.

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Magnesium Doped Hydroxyapatite-Based Coatings Obtained by Pulsed Galvanostatic Electrochemical Deposition with Adjustable Electrochemical Behavior

Cited by 31 publications

References 64 publications

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

Corrosion Resistance and Cytocompatibility of Magnesium–Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings

Plasma Spray vs. Electrochemical Deposition: Toward a Better Osteogenic Effect of Hydroxyapatite Coatings on 3D-Printed Titanium Scaffolds

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