Magnesium Deficiency Induces the Emergence of Mast Cells in the Liver of Rats

Takemoto, Satoshi; Yamamoto, Akane; Tomonaga, Shozo; Funaba, Masayuki; Matsui, Tohru

doi:10.3177/jnsv.59.560

Cited by 21 publications

(9 citation statements)

References 17 publications

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“…Among the cells of granulocytic lineage, Mg 2+ deficiency affects neutrophils most severely, but eosinophils and mast cells can also be affected. Hypomagnesemia triggers a boost of eosinophils in the peripheral blood, increasing the number of mast cells in several tissues and in the bone marrow, impairing their function [ 51 , 52 , 53 , 147 ].…”

Section: The Role Of Mg 2+ In Hematopoiesismentioning

confidence: 99%

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Lima

Fock

2020

IJMS

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Magnesium (Mg2+) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg2+ intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg2+ deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells. Immune cells and others that make up the blood system are from hematopoietic tissue in the bone marrow. The hematopoietic tissue is a tissue with high indices of renovation, and Mg2+ has a pivotal role in the cell replication process, as well as DNA and RNA synthesis. However, the impact of the intra- and extracellular disturbance of Mg2+ homeostasis on the hematopoietic tissue is little explored. This review deals specifically with the physiological requirements of Mg2+ on hematopoiesis, showing various studies related to the physiological requirements and the effects of deficiency or excess of this mineral on the hematopoiesis regulation, as well as on the specific process of erythropoiesis, granulopoiesis, lymphopoiesis, and thrombopoiesis. The literature selected includes studies in vitro, in animal models, and in humans, giving details about the impact that alterations of Mg2+ homeostasis can have on hematopoietic cells and hematopoietic tissue.

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Section: The Role Of Mg 2+ In Hematopoiesismentioning

confidence: 99%

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Lima

Fock

2020

IJMS

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“…In PEM rats infected with T. spiralis , the impaired systemic and mucosal immune response to infection was also associated with fewer mast cells in airway and intestinal mucosae (89). During magnesium deficiency, which exacerbates liver fibrosis in a rat model, depletion of mast cell numbers in the ileum, kidney, and bone marrow occurred alongside increased mast cell accumulation and functional gene expression (α- and β-chain high-affinity IgE receptors, mast cell protease 1 and 2) in the liver (92).…”

Section: Introductionmentioning

confidence: 99%

Current Understanding of Innate Immune Cell Dysfunction in Childhood Undernutrition

2019

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Undernutrition affects millions of children in low- and middle-income countries (LMIC) and underlies almost half of all deaths among children under 5 years old. The growth deficits that characterize childhood undernutrition (stunting and wasting) result from simultaneous underlying defects in multiple physiological processes, and current treatment regimens do not completely normalize these pathways. Most deaths among undernourished children are due to infections, indicating that their anti-pathogen immune responses are impaired. Defects in the body's first-line-of-defense against pathogens, the innate immune system, is a plausible yet understudied pathway that could contribute to this increased infection risk. In this review, we discuss the evidence for innate immune cell dysfunction from cohort studies of childhood undernutrition in LMIC, highlighting knowledge gaps in almost all innate immune cell types. We supplement these gaps with insights from relevant experimental models and make recommendations for how human and animal studies could be improved. A better understanding of innate immune function could inform future tractable immune-targeted interventions for childhood undernutrition to reduce mortality and improve long-term health, growth and development.

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“…Mast cell proliferation and function are also modified by Mg deficiency [ 78 ]. In addition, Mg deficit has been involved in mast cell-dependent hepatic fibrosis and steatosis [ 79 ]. In addition, Fas-induced B cell apoptosis is a Mg-dependent process [ 80 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study

et al. 2023

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Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. >1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg > 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease.

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Magnesium Deficiency Induces the Emergence of Mast Cells in the Liver of Rats

Cited by 21 publications

References 17 publications

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis

Current Understanding of Innate Immune Cell Dysfunction in Childhood Undernutrition

Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study

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