Magnesium Citrate Increases Pain Threshold and Reduces TLR4 Concentration in the Brain

Koç, Başar; Kızıldağ, Servet; Hoşgörler, Ferda; Gümüş, Hikmet; Kandiş, Sevim; Ateş, Mehmet; Uysal, Nazan

doi:10.1007/s12011-020-02384-5

Cited by 5 publications

(2 citation statements)

References 73 publications

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“…Mg supplementation improves pain relief [58]. A recent study based on the animal model of chronic pain indicated that a single dose of a Mg salt appeared to cause a weakening in the transmission and perception of nociceptive pain [59]. At the cellular level, cold temperature detection involves the process of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the membrane.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals—A Randomized, Placebo-Controlled Study

et al. 2022

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The effect of a combination of magnesium, vitamins B6, B9, B12, rhodiola and green tea/L-theanine (Mg-Teadiola) on stress was evaluated in chronically stressed, otherwise healthy individuals. Effects on stress-related quality-of-life parameters (sleep and perception of pain) were also explored. Adults with stress for ≥1 month, scoring ≥14 points on the Depression Anxiety Stress Scale (DASS)-42 questionnaire, were randomized (1:1) to receive oral Mg-Teadiola (n = 49) or a placebo (n = 51), for 28 days, with a follow-up assessment on Day 56 (NCT04391452). The primary endpoint was the change in the DASS-42 stress score from baseline to Day 28 with Mg-Teadiola versus placebo. The DASS-42 stress scores significantly decreased from baseline to Day 28 with Mg-Teadiola versus placebo (effect size, 0.29; 95% CI [0.01, 0.57]; p = 0.04). Similar reductions were observed on Day 14 (p = 0.006) and Day 56 (p = 0.02). A significant reduction in sensitivity to cold pain (p = 0.01) and a trend for lower sensitivity to warm pain was observed (p = 0.06) on Day 28. Improvements in daytime dysfunction due to sleepiness (Pittsburgh Sleep Quality Index-7 component score) were reported on Day 28, and were significant on Day 56 (p < 0.001). Mg-Teadiola is effective in managing stress in otherwise healthy individuals. Its beneficial effects on sleep and pain perception need further investigation.

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Section: Discussionmentioning

confidence: 99%

Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals—A Randomized, Placebo-Controlled Study

et al. 2022

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“…Pain threshold test was used to estimate the sensitivities to external stimuli autonomously, which was determined at 5 weeks. 20,21 The mice were placed in a customized fixed glass bucket, with their tails protruding through a perforated hole in the bucket's back cover. A point 1 cm from the tip of the tail was selected as the pain point.…”

Section: Papermentioning

confidence: 99%

Effects of Dendrobium officinale ultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

et al. 2022

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Changes in the urinary proteome of rats after short-term intake of magnesium threonate

Shen,

Yang,

Wang

et al. 2023

Preprint

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Magnesium is an important mineral in living organisms and has multiple functions in the human body, wherein it plays an important therapeutic and preventive role in a variety of diseases. In the present study, urine samples of rats before and after gavage of magnesium threonate were collected, and the urinary proteome was identified using the LC-MS/MS technique and analyzed using various databases. The results illustrated that the urinary proteome of rats was significantly altered after short-term intake of magnesium supplements and that the differential proteins and the biological functions were related to magnesium. This study innovatively establishes a method to study nutrients from the perspective of urine proteomics. This work demonstrates that the urinary proteome is capable of reflecting the effects of nutrient intake on the organism in a more systematic and comprehensive manner and has the potential to provide clues for clinical nutrition research and practice.

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Magnesium Citrate Increases Pain Threshold and Reduces TLR4 Concentration in the Brain

Cited by 5 publications

References 73 publications

Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals—A Randomized, Placebo-Controlled Study

Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals—A Randomized, Placebo-Controlled Study

Effects of Dendrobium officinale ultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

Changes in the urinary proteome of rats after short-term intake of magnesium threonate

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