Effects of <i>Dendrobium officinale</i> ultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

Shi, Meng-Lin; Yan, Ming; Shi, Jie; Yu, Jingjing; Ye, Sen-Yu; Fang, Meng; Hu, Xue-Ling; Niu, Zhuangwei; Wu, Wenyan; Chen, Si-Min; Chen, Suhong; Chen, Jianzhen; Lv, Gui‐Yuan

doi:10.1039/d2fo02158g

Cited by 11 publications

(3 citation statements)

References 38 publications

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“…[ 1 ] With the development of the social economy, many unhealthy ways of life and work, such as lack of physical exercise, irregular work and rest, environmental pollution, and an unclean diet, may cause low immunity. [ 2 ] Insufficient intake of nutrients (protein, vitamins, trace elements, etc) may also cause a decrease in the body resistance and reduce immune activity, thus having adverse effects on the immune mechanism. [ 3 ] The weakening of the body immune system can result in the emergence of different illnesses.…”

Section: Introductionmentioning

confidence: 99%

Explore the mechanism of Astragalus membranaceus and Poria cocos drug pair in improving immunity based on network pharmacology

Bai,

Ning,

Zhao

et al. 2024

Medicine

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The aim of this study was to investigate the key targets and molecular mechanisms of the drug pair Astragalus membranaceus and Poria cocos (HFDP) in the treatment of immunity. We utilized network pharmacology, molecular docking, and immune infiltration techniques in conjunction with data from the GEO database. Previous clinical studies have shown that HFDP has a positive impact on immune function. We first identified the active ingredients and targets of HFDP from the Traditional Chinese Medicine Systems Pharmacology database and the Swiss Target Prediction database, respectively. Next, we retrieved the differentially expressed genes (DEGs) related to immunity from the GEO databases. The intersection targets of the drugs and diseases were then analyzed using the STRING database for protein-protein interaction (PPI) network analysis, and the core targets were determined through topological analysis. Finally, the intersection genes were further analyzed using the DAVID database for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses. Subsequently, by analyzing the expression and prognostic survival of 12 core targets, 5 core target genes were identified, and molecular docking between the hub genes and immunity was performed. Finally, we used the CIBERSORT algorithm to analyze the immune infiltration of immunity genes In this study, 34 effective ingredients of HFDP, 530 target genes, and 568 differential genes were identified. GO and KEGG analysis showed that the intersection genes of HFDP targets and immunity-related genes were mainly related to complement and coagulation cascades, cytokine receptors, and retinol metabolism pathways. The molecular docking results showed that the 5 core genes had obvious affinity for the active ingredients of HFDP, which could be used as potential targets to improve the immunity of HFDP. Our findings suggest that HFDP is characterized by “multiple components, multiple targets, and multiple pathways” in regulating immunity. It may play an essential role in regulating immunity by regulating the expression and polymorphism of the central target genes ESR1, JUN, CYP3A4, CYP2C9, and SERPINE1.

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Section: Introductionmentioning

confidence: 99%

Explore the mechanism of Astragalus membranaceus and Poria cocos drug pair in improving immunity based on network pharmacology

Bai,

Ning,

Zhao

et al. 2024

Medicine

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“…The sub-health of body has become a growing public health concern [1][2][3]. Physical exercise has been considered the crucial factor in preventing sub-health [4].…”

Section: Introductionmentioning

confidence: 99%

A self-powered intelligent integrated sensing system for sports skill monitoring

Zhang,

Sun,

Wen

et al. 2023

Nanotechnology

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The use of green intelligent sensing systems which are based on triboelectric nanogenerators have sparked a surge of research in recent years. The development has made significant contributions to the field of promoting human health. However, the integration of an intelligent sensing system with multi-directional triboelectric nanogenerators (TENGs) remains challenges in the field of motion monitoring. To solve this research issue, this study designed a self-powered multifunctional fitness blanket (SF-MFB) which incorporates four TENGs, features multi-sensors and wireless motion monitoring capabilities. It presents a self-powered integrated sensing system which utilizes four TENG sensing units to monitor human motion. Each TENG sensing unit collects the mechanical energy generated during motion. The system is composed of SF-MFB, Bluetooth transmission terminal, and upper computer analysis terminal. Its main purpose is to wirelessly monitor and diagnose human sports skills and enables real-time human–computer interaction. The TENG integrated self-powered sensing system demonstrates practicality in sports skills monitoring, diagnosis, human–computer interaction and entertainment. This research introduces a novel approach for the application of TENG self-powered intelligent integrated sensing system in health promotion.

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“…In today's fast-paced society, an increasing number of people are dealing with inexplicable fatigue and facing an intermediate condition between health and disease, which is defined as sub-health status. 1 Ginseng Radix et Rhizoma (Panax ginseng C. A. Meyer), a historic Chinese herbal medicine, has long been used around the world as a traditional tonifying product for patients who suffer from deficiency syndromes such as feeling tired and inactive. 2 Increasing studies in the past few years have illustrated that its active ingredient ginsenosides can effectively relieve chronic fatigue, and protect the cardiovascular system and cerebral function, thus maintaining body homeostasis.…”

mentioning

confidence: 99%

Ginseng Extract Improves the Sub-health Status in Young Population: An Observational Study

Mu¹,

Gao²,

Wang³

2023

Future Integr Med

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Effects of Dendrobium officinale ultrafine powder on sub-health mice induced by unhealthy lifestyle based on neuroendocrine immune system

Abstract: Sub-health status, in which a person's mind and body exist in a low-quality state of being between disease and health, has become an urgent public health problem that cannot be...

Cited by 11 publications

References 38 publications

Explore the mechanism of Astragalus membranaceus and Poria cocos drug pair in improving immunity based on network pharmacology

Explore the mechanism of Astragalus membranaceus and Poria cocos drug pair in improving immunity based on network pharmacology

A self-powered intelligent integrated sensing system for sports skill monitoring

Ginseng Extract Improves the Sub-health Status in Young Population: An Observational Study

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