Magnesium, Calcium and Zinc Levels of Maternal and Fetal Tissues in Magnesium Deficient Rats

Abstract

The interaction of magnesium with two other mineral elements, calcium and zinc, was studied in maternal tissues and fetuses of pregnant rats fed a magnesium deficient diet throughout gestation. Reduction in maternal femur magnesium and a trend for increased kidney calcium reflected the dietary magnesium deficiency. In fetuses, however, total magnesium content was reduced and , in addition, fetal zinc content was also lower than normal in the group most severly deficient in magnesium. The possible interpretation of this magnesium-zinc interaction is discussed.

Magnesium Deficiency Anemia in the Rat Fetus

“…The effects of magnesium deficiency in the prcgnant rat were recently reported (2,8,12,19). A diet severely deficient in 7 magnesium given from the 6th to the 14th day of pregnancy produced fetal death and resorption or gross congenital malformations (11).…”

Female reproduction and pup survival and growth for mice fed a cadmium‐containing purified diet through six consecutive rounds of gestation and lactation

“…ratio and the concentration in the NAS-NRC diet for each dietary component tabulated except for iron, where the concentration in the sufficient diet was used in the calculation. The ratio for vitamin D was assumed to be the same as that for vitamin A. e Magnesium concentration in both tests diets was raised to an amount known to provide for the stress of lactation as described by Hurley et al (1976). f lron in the sufficient diet was increased over the AIN-76A concentration to an amount approximate to that shown to support reproduction in mice through three generations, after Sorbie and Valberg (1974).…”

Textural, Structural and Biological Evaluation of Hydroxyapatite Doped with Zinc at Low Concentrations

“…Among these ions, zinc is one of the most important trace elements, being found in human bones and plasma [7,8,9]. Zinc is also the second most frequently found transition metal in the human body after iron, being responsible for proper human growth and development [10,11,12,13,14]. In the natural bone tissue, can be found high quantities of zinc and its role is to preserve bone mineral density and bone metabolism [10].…”

“…In order to improve the quality of hydroxyapatite based bone implants by adding the properties of different metal ions already present in the natural surrounding tissue, researchers have concluded that one of the best methods to preserve and enhance the existing properties is to dope the hydroxyapatite [10,11,12,13,14,15,16,17]. Therefore, taking into account the specific properties of zinc and its role in the proper functioning of the human body, it is easy to understand why much attention has been paid to the integration of Zn 2+ ions in the structure of hydroxyapatite.…”