Magnesium-Based Compression Screws: A Novelty in the Clinical Use of Implants

Seitz, Jan‐Marten; Lucas, Arne; Kirschner, Martin

doi:10.1007/s11837-015-1773-1

Cited by 140 publications

(97 citation statements)

References 44 publications

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“…Mg-based and Fe-based materials have been widely investigated as potential base materials in recent years due to their biocompatible elements and mechanical characteristics [2, 8–10]. However, previous corrosion studies with bare Mg- and Fe-based metals demonstrated that their in vivo degradation performance cannot satisfy the requirement for the coronary stent yet.…”

Section: Introductionmentioning

confidence: 99%

Zn-Li alloy after extrusion and drawing: Structural, mechanical characterization, and biodegradation in abdominal aorta of rat

Zhao

Seitz

Eifler

et al. 2017

Materials Science and Engineering: C

183

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Zinc shows great promise as a bioabsorbable metal. Our early in vivo investigations implanting pure zinc wires into the abdominal aorta of Sprague-Dawley rats revealed that metallic zinc does not promote restenotic responses and may suppress the activities of inflammatory and smooth muscle cells. However, the low tensile strength of zinc remains a major concern. A cast billet of the Zn-Li alloy was produced in a vacuum induction caster under argon atmosphere, followed by a wire drawing process. Two phases of the binary alloy identified by x-ray diffraction include the zinc phase and intermetallic LiZn4 phase. Mechanical testing proved that incorporating 3 at.% of Li into Zn increased its ultimate tensile strength from 116 ± 13 MPa (pure Zn) to 274 ± 61 MPa while the ductility was held at 17 ± 7%. Implantation of 10 mm Zn-3Li wire segments into abdominal aorta of rats revealed an excellent biocompatibility of this material in the arterial environment. The biodegradation rate for Zn-3Li was found to be about 0.008 mm/yr and 0.045 mm/yr at 2 and 12 months, respectively.

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Section: Introductionmentioning

confidence: 99%

Zn-Li alloy after extrusion and drawing: Structural, mechanical characterization, and biodegradation in abdominal aorta of rat

Zhao

Seitz

Eifler

et al. 2017

Materials Science and Engineering: C

183

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“…Medical devices made of these innovative materials have to fulfill criteria relating to biological safety and biomechanical stability, which have to be maintained during the whole period of use of the device. Magnesium alloys are novel degradable medical materials, which have recently been brought to market maturity . These materials were initially investigated for suitability for musculoskeletal applications at the beginning of the 20th century and interest in them has revived in different research groups over past decades.…”

Section: Introductionmentioning

confidence: 99%

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Willbold

Weizbauer

Loos³

et al. 2016

J Biomedical Materials Res

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The first degradable implant made of a magnesium alloy, a compression screw, was launched to the clinical market in March 2013. Many different complex considerations are required for the marketing authorization of degradable implant materials. This review gives an overview of existing and proposed standards for implant testing for marketing approval. Furthermore, different common in vitro and in vivo testing methods are discussed. In some cases, animal tests are inevitable to investigate the biological safety of a novel medical material. The choice of an appropriate animal model is as important as subsequent histological examination. Furthermore, this review focuses on the results of various mechanical tests to investigate the stability of implants for temporary use. All the above aspects are examined in the context of development and testing of magnesium-based biomaterials and their progress them from bench to bedside. A brief history of the first market launch of a magnesium-based degradable implant is given. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 329-347, 2017.

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“…This eliminates the need for a subsequent, second surgery to remove the implant or device, as well as lowering the risk of infection and foreign body reaction [8][9][10][11][12]. Mg based implants have experienced good clinical successes in recent years [13][14][15][16][17].…”

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

“…The two most commonly considered applications for Mg medical devices are in orthopaedics and cardiovascular surgery [1,16,17]. The selection of appropriate animal models which reflect or match the part of the targeted part of the human system most effectively is a topic which gathers much discussion and research in biomedical materials [118,119].…”

Section: Consideration For Selecting An Appropriate In Vivo Modelmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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Magnesium-Based Compression Screws: A Novelty in the Clinical Use of Implants

Cited by 140 publications

References 44 publications

Zn-Li alloy after extrusion and drawing: Structural, mechanical characterization, and biodegradation in abdominal aorta of rat

Zn-Li alloy after extrusion and drawing: Structural, mechanical characterization, and biodegradation in abdominal aorta of rat

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

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