Magnesium-based bioceramics in orthopedic applications

Nabiyouni, Maryam; Brückner, Theresa; Zhou, Huan; Gbureck, Uwe; Bhaduri, Sarit B.

doi:10.1016/j.actbio.2017.11.033

Cited by 254 publications

(158 citation statements)

References 237 publications

Supporting

Mentioning

153

Contrasting

Unclassified

Order By: Relevance

“…Bioactive materials such as bioceramics and bioactive glasses (BGs) have been widely used for repair and regeneration of the bone and tooth defects . The biomaterials are capable of promoting the bone generation and chemical bonding to surrounding tissue, while they are nontoxic, bioresorbable, nonallergenic, and noninflammatory . Bioactive materials are usually used in the form of dense or porous blocks, granules, and ductile shapes .…”

Section: Introductionmentioning

confidence: 99%

Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes

Rasti

Hesaraki

Nezafati

2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

Injectable composite pastes were prepared using melt‐derived 45S5 bioactive glass and tragacanth crosslinked by (3‐glycidyloxypropyl)trimethoxysilane (GPTMS). The effect of powder to liquid ratio (P:L = 1.0:2.0–1.0:2.5) and GPTMS/tragacanth ratio (0.0–1.5) on the injectability, swelling behavior, rheology, bioactivity, and cellular behavior of the pastes was investigated. Based on the results, the apparent stability and consistency of the pastes increased upon crosslinking by GPTMS. Due to the increased interactions between tragacanth and glass, a hysteresis loop with larger area was formed in the presence of GPTMS. With increase of GPTMS:tragacanth ratio from 0 to 1.5, the swelling percent dropped from 24.65 to 16.25% after 24 h and the degradation percent also went down from 27.89 to 9.11% after 21 days in the simulated body fluid. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay showed a drop in the optical density of MG63 osteoblasts up to 30.07% after exposure to the GPTMS‐crosslinked composite pastes for 3 days. However, the number of viable cells gradually increased in the presence of the pastes and the cell morphology remained unchanged over time. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47604.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes

Rasti

Hesaraki

Nezafati

2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Magnesium (Mg) alloys are highly biocompatible materials with emerging applications in bone reconstruction plates (especially in children, pediatric treatment of fractures, or congenital defects) and cardiovascular stents . Nevertheless, the in vivo corrosion behavior leads to H 2 gas formation as a degradation product and can affect the healing process . In particular, Ca‐bearing Mg alloys (Mg‐Ca) are excellent candidates for biomedical applications as Ca constitutes a key element of human bone.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Functionalized Polymeric‐Ceramic Coatings on Mg‐Ca Alloys for Biodegradable Implant Applications

Santos-Coquillat

Martínez-Campos

Vargas-Alfredo

et al. 2019

Macromolecular Bioscience

View full text Add to dashboard Cite

The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/mabi.201900179. Hierarchical BiomaterialMagnesium-based implants present several advantages for clinical applications, in particular due to their biocompatibility and degradability. However, degradation products can affect negatively the cell activity. In this work, a combined coating strategy to control the implant degradation and cell regulation processes is evaluated, including plasma electrolytic oxidation (PEO) that produces a 13 µm-thick Ca, P, and Si containing ceramic coating with surface porosity, and breath figures (BF) approach that produces a porous polymeric poly(ε-caprolactone) surface. The degradation of PCL-PEO-coated Mg hierarchical scaffold can be tailored to promote cell adhesion and proliferation into the porous structure. As a result, cell culture can colonize the inner PEOceramic coating structure where higher amount of bioelements are present. The Mg/PEO/PCL/BF scaffolds exhibit equally good or better premyoblast cell adhesion and proliferation compared with Ti CP control. The biological behavior of this new hierarchical functionalized scaffold can improve the implantation success in bone and cardiovascular clinical applications.

show abstract

“…This substitution requires the structure of hydroxyapatite to favor the transition to β-TCP. [22][23][24] It can thus be concluded that due to a higher concentration of Mg 2+ ions in thermally treated HAp-10%Mg samples at 1000°C and 1100°C, the transition to β-TCP is favored.…”

Section: X-ray Diffraction (Xrd)mentioning

confidence: 99%

Ceramics based on calcium phosphates substituted with magnesium ions for bone regeneration

Ghiţulică

Cucuruz

Voicu

et al. 2019

Int J Applied Ceramic Tech

View full text Add to dashboard Cite

In this study, chemical precipitation methods were used to obtain ceramic materials doped with magnesium ions in order to improve the regeneration properties of materials used for tissue engineering. Two different ratios of magnesium oxide were used to dope the ceramic powder, more precisely 5% and 10%. The synthesized materials were characterized to determine the calcination temperature of the precursor powder by means of thermal analysis; to determine the mineralogical composition, X-ray diffraction was employed and the scanning electron microscopy was used to determine the microstructure. To make use of these ceramics as biomaterials, viability and proliferation cell tests have been performed. Since synthetic materials have several limitations with regard to medical applications, the materials based on HAp substituted with Mg ions are a promising solution for the regeneration of bone defects because they have a similar bone structure. The presence of Mg in the material proves to be beneficial because this element plays an important role in bone cell regeneration, and more specifically, in stimulating osteoblast proliferation. The materials synthesized in this work present a suitable morphology for uses in bone regeneration because they offer to cells a friendly environment for growth and anchoring.

show abstract

Magnesium-based bioceramics in orthopedic applications

Cited by 254 publications

References 237 publications

Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes

Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes

Hierarchical Functionalized Polymeric‐Ceramic Coatings on Mg‐Ca Alloys for Biodegradable Implant Applications

Ceramics based on calcium phosphates substituted with magnesium ions for bone regeneration

Contact Info

Product

Resources

About