Magnesium and Liver Metabolism Through the Lifespan

Bravo, Miren; Simón, Jorge; González‐Recio, Irene; Martínez-Cruz, L.A.; Goikoetxea‐Usandizaga, Naroa; Martínez‐Chantar, María Luz

doi:10.1016/j.advnut.2023.05.009

Cited by 4 publications

(2 citation statements)

References 140 publications

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“…The liver is a major detoxification organ [50], and it plays a crucial role in maintaining metabolic homeostasis [51]. Additionally, the liver metabolizes various compounds that generate free radicals.…”

Section: Discussionmentioning

confidence: 99%

Liquid Chromatography/Tandem Mass Spectrometry Analysis of Sophora flavescens Aiton and Protective Effects against Alcohol-Induced Liver Injury and Oxidative Stress in Mice

Yang,

Kim,

Yang

et al. 2024

Antioxidants

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In this study, we investigated the hepatoprotective effects of an ethanol extract of Sophora flavescens Aiton (ESF) on an alcohol-induced liver disease mouse model. Alcoholic liver disease (ALD) was caused by the administration of ethanol to male C57/BL6 mice who were given a Lieber−DeCarli liquid diet, including ethanol. The alcoholic fatty liver disease mice were orally administered ESF (100 and 200 mg/kg bw/day) or silymarin (50 mg/kg bw/day), which served as a positive control every day for 16 days. The findings suggest that ESF enhances hepatoprotective benefits by significantly decreasing serum levels of aspartate transaminase (AST) and alanine transaminase (ALT), markers for liver injury. Furthermore, ESF alleviated the accumulation of triglyceride (TG) and total cholesterol (TC), increased serum levels of superoxide dismutase (SOD) and glutathione (GSH), and improved serum alcohol dehydrogenase (ADH) activity in the alcoholic fatty liver disease mice model. Cells and organisms rely on the Kelch-like ECH-associated protein 1- Nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) system as a critical defensive mechanism in response to oxidative stress. Therefore, Nrf2 plays an important role in ALD antioxidant responses, and its level is decreased by increased reactive oxidation stress (ROS) in the liver. ESF increased Nrf2, which was decreased in ethanol-damaged livers. Additionally, four polyphenol compounds were identified through a qualitative analysis of the ESF using LC-MS/MS. This study confirmed ESF’s antioxidative and hangover-elimination effects and suggested the possibility of using Sophora flavescens Aiton (SF) to treat ALD.

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Section: Discussionmentioning

confidence: 99%

Liquid Chromatography/Tandem Mass Spectrometry Analysis of Sophora flavescens Aiton and Protective Effects against Alcohol-Induced Liver Injury and Oxidative Stress in Mice

Yang,

Kim,

Yang

et al. 2024

Antioxidants

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“…Consequently, it needs to be regularly ingested from the diet to meet recommended intake levels and prevent deficiency. In this regard, it is not only crucial to identify potential sources of magnesium but also to consider its bioavailability and factors that could influence its absorption and excretion [20,51]. Good dietary sources of magnesium include seeds, legumes (such as peas and beans), green vegetables (particularly spinach), nuts (including peanuts, cashews, almonds, and Brazil nuts), whole grain breads and cereals (such as millet and brown rice), select fruits (such as dried apricots, raisins, dried bananas, and avocado), cocoa, and seafood [20,30,51,52].…”

Section: Magnesiummentioning

confidence: 99%

The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review

Souza,

Vasconcelos,

Dias

et al. 2023

Nutrients

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Aging is characterized by significant physiological changes, with the degree of decline varying significantly among individuals. The preservation of intrinsic capacity over the course of an individual’s lifespan is fundamental for healthy aging. Locomotion, which entails the capacity for independent movement, is intricately connected with various dimensions of human life, including cognition, vitality, sensory perception, and psychological well-being. Notably, skeletal muscle functions as a pivotal nexus within this intricate framework. Any perturbation in its functionality can manifest as compromised physical performance and an elevated susceptibility to frailty. Magnesium is an essential mineral that plays a central role in approximately 800 biochemical reactions within the human body. Its distinctive physical and chemical attributes render it an indispensable stabilizing factor in the orchestration of diverse cellular reactions and organelle functions, thereby rendering it irreplaceable in processes directly impacting muscle health. This narrative review offers a comprehensive exploration of the pivotal role played by magnesium in maintaining skeletal muscle integrity, emphasizing the critical importance of maintaining optimal magnesium levels for promoting healthy aging.

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Selenium-enriched yeast regulates aquaporins to alleviate atrazine-induced hepatic ionic homeostasis disturbance in Japanese quails

Wang,

Li,

Wang

et al. 2024

International Journal of Biological Macromolecules

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Magnesium and Liver Metabolism Through the Lifespan

Cited by 4 publications

References 140 publications

Liquid Chromatography/Tandem Mass Spectrometry Analysis of Sophora flavescens Aiton and Protective Effects against Alcohol-Induced Liver Injury and Oxidative Stress in Mice

Liquid Chromatography/Tandem Mass Spectrometry Analysis of Sophora flavescens Aiton and Protective Effects against Alcohol-Induced Liver Injury and Oxidative Stress in Mice

The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review

Selenium-enriched yeast regulates aquaporins to alleviate atrazine-induced hepatic ionic homeostasis disturbance in Japanese quails

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