The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review

Abstract

Aging is characterized by significant physiological changes, with the degree of decline varying significantly among individuals. The preservation of intrinsic capacity over the course of an individual’s lifespan is fundamental for healthy aging. Locomotion, which entails the capacity for independent movement, is intricately connected with various dimensions of human life, including cognition, vitality, sensory perception, and psychological well-being. Notably, skeletal muscle functions as a pivotal nexus within this intricate framework. Any perturbation in its functionality can manifest as compromised physical performance and an elevated susceptibility to frailty. Magnesium is an essential mineral that plays a central role in approximately 800 biochemical reactions within the human body. Its distinctive physical and chemical attributes render it an indispensable stabilizing factor in the orchestration of diverse cellular reactions and organelle functions, thereby rendering it irreplaceable in processes directly impacting muscle health. This narrative review offers a comprehensive exploration of the pivotal role played by magnesium in maintaining skeletal muscle integrity, emphasizing the critical importance of maintaining optimal magnesium levels for promoting healthy aging.

Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview

“…Mg plays a foundational role in various cellular processes. Primarily, Mg is crucial for the chemistry of nucleic acids within the cells of several living organisms ( Figure 2 , left panel) [ 223 , 224 ]. The three-dimensional structures of RNA and DNA heavily rely on the presence of Mg ions.…”

“…Furthermore, Mg ions contribute to cell metabolism and glycolysis. Additionally, Mg 2+ is a Ca 2+ antagonist during cellular signaling and muscle contraction, indicating the importance of maintaining optimal concentrations of these ions [ 223 , 231 ].…”

“…While calcium ions facilitate muscular contraction, magnesium ions compete with calcium to promote muscular relaxation. Consequently, Mg supplementation is commonly employed to relieve muscular cramps [ 212 , 223 ]. Additionally, given its importance in glycolysis, a correlation between low Mg intake and type 2 diabetes has been proposed as a contributing factor to this condition [ 224 , 246 ].…”

Сок Шиповника: 10 Научно Доказанных Фактов Пользы Целебного Напитка

“…[3]  Кальций (169 мг) -микроэлемент способствует прочности костей и росту здоровой костной ткани, в частности, препятствует развитию остеопороза [4] , также, как показывают исследования, его недостаток может стать причиной развития болезни Альцгеймера и преждевременного старения мозга. [5]  Магний (69 мг) -нормализует сердечный риск, расслабляет мышечные ткани и способствует их здоровому функционированию [6] , помогает избавиться от судорог, в комплексе с кальцием повышает плотность костей, предотвращая их хрупкость и ломкость, что особенно актуально для людей старческого возраста, полезен для мозга и ЦНС -стабилизирует психо-эмоциональное состояние, помогает справляться со стрессами и избегать депрессий, рекомендуется в качество дополнительного средства при лечении бессонницы. [7]  Ликопин (6800 мкг) -каротиноидный пигмент, мощный антиоксидант.…”