Magic-Angle-Gradient Double-Quantum-Filtered COSY

Vanzijl, P.C.M.; Johnson, M. O'Neil; Mori, Susumu; Hurd, Ralph E.

doi:10.1006/jmra.1995.1092

Cited by 67 publications

(30 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Experiments were performed with the DQC-encode gradients applied along the static magnetic field (B 0 ) direction, along the magic angle with respect to B 0 , and along the directions perpendicular to B 0 . The theoretical treatment predicts that intermolecular dipole-dipole interactions vanish when magnetic field gradients are applied at the magic angle (7,22,23). With the DQC-encode gradients applied along the directions perpendicular to the B 0 field, the detected signal intensity from DQCs should be half of that acquired when the DQC-encode gradients are along the B 0 direction (7).…”

Section: Resultsmentioning

confidence: 99%

In vivo intermolecular double-quantum imaging on a clinical 1.5 T MR scanner

2000

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

In vivo intermolecular double-quantum imaging on a clinical 1.5 T MR scanner

2000

View full text Add to dashboard Cite

“…57,58 Methods for reducing overlapped metabolite resonances and increasing the molecular structural information include dispersion of the spectral data using a second dimension, for which a range of 2D pulse sequences exist. 59,60 Once a potential biomarker candidate of disease class or response has been identified, then the NMR spectroscopic detection can be physically integrated with HPLC-MS to effect simultaneous molecular characterization of separated biomolecules from biofluid samples. 61 The recent development of ultra high-pressure liquid chromatography (UPLC) has further enhanced the capabilities for metabolite isolation and detection.…”

Section: Key Analytical Developments In Nmr Spectroscopymentioning

confidence: 99%

The application of NMR-based metabonomics in neurological disorders

2006

View full text Add to dashboard Cite

Summary: Advances in postgenomic technologies have radically changed the information output from complex biological systems, generating vast amounts of high complexity data that can be interpreted by means of chemometric and bioinformatic methods to achieve disease diagnosis and prognosis. Highresolution nuclear magnetic resonance (NMR) spectroscopy of biofluids such as plasma, cerebrospinal fluid (CSF), and urine can generate robust, interpretable metabolic fingerprints that contain latent information relating to physiological or pathological status. This technology has been successfully applied to both preclinical and clinical studies of neurodegenerative diseases such as Huntington's disease, muscular dystrophy, and cerebellar ataxia. An extension of this technology, 1 H magicangle-spinning (HRMAS) NMR spectroscopy, can be used to generate metabolic information on small intact tissue samples, providing a metabolic link between metabolic profiling of biofluids and histology. In this review we provide a summary of high-resolution NMR studies in neurodegenerative disease and explore the potential of metabonomics in evaluating disease progression with respect to therapeutic intervention.

show abstract

“…1) to minimize the potential shift of the coherence transfer echo (see the Appendix). The double-quantum (DQ) gradient filter produces a gradient vector with a magic angle with respect to the longitudinal axis (z-axis) (22).…”

Section: Pulse Sequencementioning

confidence: 99%