Madurella mycetomatis infection following allogenic stem cell transplantation for aplastic anemia

Sharma, Sanjeev; Mukherjee, A. S.; Singh, Avinash Kumar; Seth, Tulika; Kumar, Suman; Mishra, Pravas; Xess, Immaculata; Gupta, Somesh; Mahapatra, Manoranjan; Pati, Haraprasad

doi:10.4084/mjhid.2012.038

Cited by 5 publications

(13 citation statements)

References 8 publications

(10 reference statements)

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“…with immunodeficiency it is assumed that an increased and faster proliferation of the microorganism in the tissue could be the consequence . An Indian patient suffered from an infection due to Madurella mycetomatis after allogenic stem cell transplantation because of an aplastic anaemia …”

Section: Clinical Picture Of Mycetomamentioning

confidence: 99%

“…28,29 An Indian patient suffered from an infection due to Madurella mycetomatis after allogenic stem cell transplantation because of an aplastic anaemia. 30 Grain formation in mycetomas A significant sign of a mycetoma is the painless tumour-like swelling of the subcutaneous tissue, also called tumefaction. Distinctive for both eumycetoma and actinomycetoma, is the formation of grains.…”

Section: Pathogenesismentioning

confidence: 99%

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Eumycetoma and actinomycetoma – an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy

Nenoff

Sande

Fahal

et al. 2015

Acad Dermatol Venereol

100

118

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Mycetoma is a chronic putrid infection of the cutaneous and subcutaneous tissue concerning predominantly the feet, and more rarely other body parts. Mycetoma can be caused by both fungi (eumycetoma) and bacteria (actinomycetoma). Mode of infection is an inoculation of the causative microorganism via small injuries of the skin. The clinical correlate of both forms of mycetoma is tumescence with abscesses, painless nodules, sinuses and discharge. The latter is commonly serous-purulent and contains grains (filamentous granules) which can be expressed for diagnostic purposes. Distinctive for both eumycetoma and actinomycetoma, are the formation of grains. Grains represent microcolonies of the microorganism in vivo in the vital tissue. The most successful treatment option for eumycetomas offers itraconazole in a dosage of 200 mg twice daily. This triazole antifungal is considered as 'gold standard' for eumycetomas. Alternatively, the cheaper ketoconazole was widely used, however, it was currently stopped by the FDA. Actinomycetomas should be treated by the combination of trimethoprim-sulphamethoxazole (co-trimoxazole 80/400 to 160/800 mg per day) and amikacin 15 mg/kg body weight per day. Mycetomas are neglected infections of the poor. They are more than a medical challenge. In rural areas of Africa, Asia and South America mycetomas lead to socio-economic consequences involving the affected patients, their families and the society in general.

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Section: Clinical Picture Of Mycetomamentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Eumycetoma and actinomycetoma – an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy

Nenoff

Sande

Fahal

et al. 2015

Acad Dermatol Venereol

100

118

View full text Add to dashboard Cite

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“…All the patients were male, with a median (range) age of 38 (22-63) years. All the patients originated from a Madura footendemic country, namely, Angola (Cunha et al, 2018), Curaçao (Meis et al, 2000), India (Sharma et al, 2012) and Somalia (present paper). Two patients, ours, had received a kidney transplant (Meis et al, 2000), one a heart transplant (Cunha et al, 2018) and one an allogenic stem cell transplantation (Sharma et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Mycetoma caused by Madurella mycetomatis in immunocompromised patients – a case report and systematic literature review

Hoogervorst

Coul

Ray

et al. 2022

J. Bone Joint Infect.

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Abstract. The aim of this study was to review the available literature concerning Madura foot (“mycetoma”) caused by Madurella mycetomatis in immunocompromised patients. With a systematic literature search, we identified only three papers, describing a total of three immunocompromised patients. Hence, the clinical presentation and prognosis of the disease in this patient population have not yet been well described. In addition, we present a case from our institution, illustrating the complexity of the treatment of this rare disease. Although very rare in non-endemic countries, we emphasize that mycetoma should be included in the differential diagnoses of (immunocompromised) patients who have been residing in a geographical area where the disease is endemic and presenting with soft tissue inflammation of one of the extremities.

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“…In some patients with short history it may present with massive swelling, involvement of deeper tissues and bone and in contrast, others may present with few, long standing skin lesions with no substantial deeper tissue destruction. Mycetoma generally affects individuals who are otherwise normal but very rarely cases in immunocompromised patients are reported, like one in the foot of a recipient of an allogenic stem cell transplant but the course of the disease did not seem to be unusual in the patient [7] and the disease responded to surgery and voriconazole treatment. Our case was a peculiar one with very few superficial signs of the disease but with massive deep tissue destruction.…”

Section: Discussionmentioning

confidence: 99%

Unusual Presentation of Madurella Mycetomatis Mycetoma in a Paediatric Patient in India

Tendolkar¹

2016

MOJCR

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Eumycetoma due to Madurella mycetomatis is of worldwide occurrence. It usually presents with signs of tumefaction, sinuses and grains which are the hallmarks in diagnosis of the disease. The present case was an eight year old boy admitted with moderate swelling of the forearm with a discharging sinus. The swelling had developed over a four month period. He gave history of trauma one year back to the site. He also had fever for two months. Imaging studies showed large cystic lesions in the bone. On surgical exploration it was observed that a large mass of compacted black grains (5cm X4cm) was filling the space between the radius and ulna bones. A mycological examination of the black grains revealed fungal hyphae and culture showed growth of Madurella mycetomatis. An extensive surgical debridement and voriconazole treatment for 6 weeks relieved the clinical symptoms but there was little radiological improvement. This case represents a rare presentation of mycetoma with a rapid progression of the disease over a few months, not commonly seen with eumycotic agents. The young age of the patient and the site were unusual findings. The external signs were mild and disproportionate to the extensively destructive disease seen underneath. These findings highlight the importance of an early diagnosis to prevent the devastation caused by this relentless infection which may be especially challenging in cases like this which present with unusual features.

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Madurella mycetomatis infection following allogenic stem cell transplantation for aplastic anemia

Cited by 5 publications

References 8 publications

Eumycetoma and actinomycetoma – an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy

Eumycetoma and actinomycetoma – an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy

Mycetoma caused by Madurella mycetomatis in immunocompromised patients – a case report and systematic literature review

Unusual Presentation of Madurella Mycetomatis Mycetoma in a Paediatric Patient in India

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