MADS: the missing link between identity and growth?

Dornelas, Marcelo Carnier; Patreze, Camila Maistro; Angenent, Gerco C.; Immink, Richard G. H.

doi:10.1016/j.tplants.2010.11.003

Cited by 79 publications

(71 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Molecular Mechanisms Of Action Of Mads-domain Proteinsmentioning

confidence: 88%

“…Among the potential direct SEP3 target genes, auxin-response genes could be related to the role of SEP3 in floral organ outgrowth and morphogenesis . The current data suggest that floral homeotic MADS-domain proteins directly regulate the expression of a variety of genes that are important for the growth, shape and structure of different organs, indicating that floral MADS-domain proteins not only specify organ identity at the onset of organ primordia initiation, but are also involved in subsequent differentiation processes (reviewed by Ito, 2011;Dornelas et al, 2011).The data also reveal complex regulatory interactions among MADS family members and the existence of a large number of positive and negative (auto)regulatory loops. Negative-feedback loops are required for developmental phase switches and have been hypothesized to be important for MADS-box gene function during the transition from vegetative to reproductive growth de Folter et al, 2005), while feedforward loops are important for robust and balanced expression of target genes.…”

mentioning

confidence: 91%

See 1 more Smart Citation

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

et al. 2012

Self Cite

View full text Add to dashboard Cite

SummaryMembers of the MADS-box transcription factor family play essential roles in almost every developmental process in plants. Many MADS-box genes have conserved functions across the flowering plants, but some have acquired novel functions in specific species during evolution. The analyses of MADS-domain protein interactions and target genes have provided new insights into their molecular functions. Here, we review recent findings on MADS-box gene functions in Arabidopsis and discuss the evolutionary history and functional diversification of this gene family in plants. We also discuss possible mechanisms of action of MADS-domain proteins based on their interactions with chromatin-associated factors and other transcriptional regulators. Key words: MADS-box genes, Plant development, Evolution, Transcriptional regulationIntroduction MADS-domain transcription factors comprise one of the beststudied gene families in plants and members of this family play prominent roles in plant development. Two decades ago, the first MADS-box genes AGAMOUS (AG) from Arabidopsis thaliana (Yanofsky et al., 1990) and DEFICIENS (DEF) from Antirrhinum majus (Schwarz-Sommer et al., 1990) were discovered as regulators of floral organ identity. The sequence of the ~60 amino acid DNA-binding domains within these proteins showed striking similarities to that of the previously characterized proteins serum response factor (SRF) in Homo sapiens (Norman et al., 1988) and Minichromosome maintenance 1 (Mcm1) in Saccharomyces cerevisiae (Passmore et al., 1988). This shared and conserved domain was named the MADS domain (for MCM1, AG, DEF and SRF) and is present in all MADS-domain transcription factor family members (Schwarz-Sommer et al., 1990). Structural analysis of animal and yeast MADS domains showed that the N-terminal and central parts of the MADS domain make contacts with the DNA, while the C-terminal part of this domain contributes mainly to protein dimerization, resulting in a DNA-binding protein dimer consisting of two interacting MADS monomers (e.g. Pellegrini et al., 1995;Huang et al., 2000). Over the past 22 years, many MADS-box gene functions were uncovered in the model species Arabidopsis thaliana and in other flowering plants. Important model plant species for MADS-box gene research include snapdragon (Antirrhinum majus) (reviewed by Schwarz-Sommer et al., 2003), tomato (Solanum lycopersicum), petunia (Petunia hybrida) (Gerats and Vandenbussche, 2005), gerbera (Gerbera hybrida) (Teeri et al., 2006) and rice (Oryza sativa) (reviewed by Yoshida and Nagato, 2011).Initially, MADS-box genes were found to be major players in floral organ specification, but more recent studies revealed functions for MADS-box genes in the morphogenesis of almost all organs and throughout the plant life cycle, from embryo to gametophyte development. The MADS-box gene family in higher plants is significantly larger than that found in animals or fungi, with more than 100 genes in representative flowering plant Development 139, 3081-3098 (2012) REVIEW Box 1...

show abstract

Section: Molecular Mechanisms Of Action Of Mads-domain Proteinsmentioning

confidence: 88%

mentioning

confidence: 91%

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some of these CaM binding proteins are downregulated upon exposure to cold (AGL3, AGL8, AGL15, and AGL32) (Hannah et al, 2005), raising the possibility that they may be transcriptional regulators mediating cold stress responses. Many of these TFs are implicated in floral development and flowering (Dornelas et al, 2011). Furthermore, several wheat (Triticum aestivum) genes associated with flower development are implicated in abiotic stress responses (Tardif et al, 2007).…”

Section: Coldmentioning

confidence: 99%

Coping with Stresses: Roles of Calcium- and Calcium/Calmodulin-Regulated Gene Expression

Ali²,

et al. 2011

View full text Add to dashboard Cite

Abiotic and biotic stresses are major limiting factors of crop yields and cause billions of dollars of losses annually around the world. It is hoped that understanding at the molecular level how plants respond to adverse conditions and adapt to a changing environment will help in developing plants that can better cope with stresses. Acquisition of stress tolerance requires orchestration of a multitude of biochemical and physiological changes, and most of these depend on changes in gene expression. Research during the last two decades has established that different stresses cause signal-specific changes in cellular Ca 2+ level, which functions as a messenger in modulating diverse physiological processes that are important for stress adaptation. In recent years, many Ca 2+ and Ca 2+ /calmodulin (CaM) binding transcription factors (TFs) have been identified in plants. Functional analyses of some of these TFs indicate that they play key roles in stress signaling pathways. Here, we review recent progress in this area with emphasis on the roles of Ca 2+ -and Ca 2+ /CaMregulated transcription in stress responses. We will discuss emerging paradigms in the field, highlight the areas that need further investigation, and present some promising novel high-throughput tools to address Ca 2+ -regulated transcriptional networks.

show abstract

“…In Solanum, FW2.2, FAS and LC, as negative regulators, account for 480% of the berry size difference between WT tomato and its cultivated relatives 13,17,18 . A few characterized regulators could explain an exaggerated difference in the floral organ size [48][49][50] . However, molecular genetic mechanism of co-variation of floral organs and post-floral organs (fruits and seeds) is not well studied in plants.…”

Section: Articlementioning

confidence: 99%

Regulatory change at Physalis Organ Size 1 correlates to natural variation in tomatillo reproductive organ size

Wang

et al. 2014

Nat Commun

View full text Add to dashboard Cite

The genetic basis of size variation in the reproductive organs of tomatillo (Physalis philadelphica) is unknown. Here we report that the expression levels of the gene Physalis Organ Size 1 (POS1) are positively associated with size variation in P. philadelphica reproductive organs such flowers, berries and seeds. POS1 knockdown results in smaller flowers and berries with smaller cells as compared with their wild-type counterparts. Conversely, POS1 overexpression promotes organ size without increasing the cell number. The first introns of the POS1 alleles from the large, intermediate and small tomatillo groups contain one, two and three 37-bp repeats, respectively. Furthermore, our results show that copy variation of repeats in the first intron of POS1 alleles results in differential expression of this gene. Thus, co-variation in tomatillo reproductive organ sizes can be attributed to the novel regulatory variation in POS1.

show abstract

MADS: the missing link between identity and growth?

Cited by 79 publications

References 84 publications

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

Coping with Stresses: Roles of Calcium- and Calcium/Calmodulin-Regulated Gene Expression

Regulatory change at Physalis Organ Size 1 correlates to natural variation in tomatillo reproductive organ size

Contact Info

Product

Resources

About