Coping with Stresses: Roles of Calcium- and Calcium/Calmodulin-Regulated Gene Expression

Reddy, Anireddy S. N.; Ali, Gul Shad; Čelešnik, Helena; Day, Irene S.

doi:10.1105/tpc.111.084988

Cited by 648 publications

(510 citation statements)

References 259 publications

(400 reference statements)

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“…Calcium signaling is known to play an important role in the activation of plant defense responses to abiotic and biotic stresses, e.g., stress-induced phytoalexin biosynthesis (Lecourieux et al 2006;Reddy et al 2011). A number of reports provided evidence that calcium signaling is implicated in the regulation of stilbene biosynthesis.…”

Section: Signaling Pathways Regulating Stilbene Biosynthesis Regulatimentioning

confidence: 99%

Regulation of stilbene biosynthesis in plants

Dubrovina

Kiselev

2017

Planta

134

126

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Main conclusion This review analyzes the advances in understanding the natural signaling pathways and environmental factors regulating stilbene biosynthesis. We also discuss the studies reporting on stilbene content and repertoire in plants.Stilbenes, including the most-studied stilbene resveratrol, are a family of phenolic plant secondary metabolites that have been the subject of intensive research due to their valuable pharmaceutical effects and contribution to plant disease resistance. Understanding the natural mechanisms regulating stilbene biosynthesis in plants could be useful for both the development of new plant protection strategies and for commercial stilbene production. In this review, we focus on the environmental factors and cell signaling pathways regulating stilbene biosynthesis in plants and make a comparison with the regulation of flavonoid biosynthesis. This review also analyzes the recent data on stilbene biosynthetic genes and summarizes the available studies reporting on both stilbene content and stilbene composition in different plant families.

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Section: Signaling Pathways Regulating Stilbene Biosynthesis Regulatimentioning

confidence: 99%

Regulation of stilbene biosynthesis in plants

Dubrovina

Kiselev

2017

Planta

134

126

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“…It is well known that the typical calmodulin act as Ca 2+ relay by interacting and modulating the activity of target proteins. 1 Experimental evidences demonstrate the ability of CML9 to bind Ca 2+ ions 11 and CML9 was shown to fulfil under certain conditions the role of CaM in yeast. 12 More recently, Perochon et al 13,14 and Popescu et al 15 identified CML9-interacting proteins suggesting that CML9 participates in Ca 2+ -regulated processes in plant.…”

Section: What Could Be the Relationship Between Cml9 And The Flagellimentioning

confidence: 99%

“…1 These Ca 2+ signals are perceived by different Ca 2+ sensors, and calmodulin (CaM) is one of the best characterized Ca 2+ sensors in eukaryotes. Calmodulinlike (CML) proteins extend the Ca 2+ -toolkit in plants; CMLs share sequence similarity with the ubiquitous and highly conserved CaM, however, except for some of them, their roles at physiological and molecular levels remain largely unknown.…”

mentioning

confidence: 99%

CML9, a multifunctionalArabidopsis thalianacalmodulin-like protein involved in stress responses and plant growth?

Leba

Perochon²,

Cheval

et al. 2012

Plant Signaling & Behavior

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Many stimuli such as hormones and stress factors elicit changes in intracellular calcium content that serve to convey information and activate appropriate responses. 1 These Ca 2+ signals are perceived by different Ca 2+ sensors, and calmodulin (CaM) is one of the best characterized Ca 2+ sensors in eukaryotes. Calmodulinlike (CML) proteins extend the Ca 2+ -toolkit in plants; CMLs share sequence similarity with the ubiquitous and highly conserved CaM, however, except for some of them, their roles at physiological and molecular levels remain largely unknown. 2,3In our group, we reported data on Arabidopsis thaliana CML9 that exhibits 46% amino acid sequence identity with CaM. 4,5 We showed that CML9 transcripts are found in all organs and that CML9 gene is rapidly induced by both abiotic and biotic stress. In a recent publication in Plant Journal, we demonstrated that CML9 expression is also rapidly induced by the phytopathogenic bacteria Pseudomonas syringae pv tomato DC3000 (Pst DC3000) 4 and that this upregulation belongs to salicylic acid (SA) production and to the flagellin perception receptor FLS2. Moreover, exogenous applications of SA or flg22, the biological active peptide of flagellin, are also able to induce rapid and transient CML9 gene expression and using a reverse genetic approach, we established that CML9 participates in plant innate immunity through a flagellin-dependent signaling pathway. 4 In addition to mediate plant innate immunity, flagellin and flg22 are also known to inhibit root elongation and seedling growth.6 Thus, we explored this facet of flagellin effect and we bring here new informations on plant growth behavior of CML9 overexpressing and knockout lines upon flg22 treatments and Plants have evolved complex signaling networks to respond to their fluctuating environment and adapt their growth and development. Calcium-dependent signaling pathways play key role in the onset of these adaptive responses. in plant cells, the intracellular calcium transients are triggered by numerous stimuli and it is supposed that the large repertory of calcium sensors present in higher plants could contribute to integrate these signals in physiological responses. here, we present data on CmL9, a calmodulin-like protein that appears to be involved in plant responses to both biotic and abiotic stress. using a reverse genetic approach based on gain and loss of function mutants, we present here data indicating that this CmL might also be involved in root growth control in response to the flagellin, a pathogen-associated molecular pattern (PamP) also involved in plant immunity. Keywords: Calmodulin-like protein, Arabidopsis thaliana, root growth, flagellin, gibberellins discuss the possible involvement of CML9 in plant growth control through hormonal compounds. CML9, a multifunctional The cml9 Genotypes Exhibit Altered Responses to FlagellinAs previously showed, cml9 mutants or CML9 overexpressors exhibit respectively an enhanced susceptibility and a better resistance against phytopathogenic bacteria. 4 Using...

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“…CaM interacts with a variety of DNA-binding proteins/transcription factors. Over 90 CaM-binding proteins (CBPs) are DNA-binding proteins that fit into several families of known transcription factors, including CAMTAs (also known as AtSRs), WRKY IID, bZIP, MYB, Trihelix, NAC, CBP60, MADS, and GRAS (Reddy et al, 2011a), and the CaMBDs in some of the newly identified CaM-binding transcription factors remain to be determined (Popescu et al, 2007). In this section, we will focus only on recent developments in the direct regulation of Ca 2+ /CaM on transcriptional machinery through the actions of CAMTAs/SRs.…”

Section: Proposed Activation Mechanism Of Ccamkmentioning

confidence: 99%