Macular thickness predictive of visual field sensitivity in ischaemic optic neuropathy

The objective of this study was to evaluate the measurements of choroidal thickness (CT) in patients with non-arteritic anterior ischaemic optic neuropathy (NAION) at the acute and chronic stages. This case-control study compares three groups: Group 1 included 23 eyes of 23 patients with chronic NAION, Group 2 consisted of 24 eyes of 24 patients with acute NAION, and Group 3 included 24 eyes of 24 age-matched control subjects. The average CTs for Group 1, Group 2, and Group 3 were 261.24 ± 50.04, 280.05 ± 74.94, and 254.74 ± 50.11 µm, respectively. For all measurements, no statistical significance was found between the groups (p = 0.319, 0.357, 0.680, and 0.178 for the CTs as average, foveal, superior, and inferior, respectively). Similarly, there was no difference between the CT measurements of the affected and unaffected eyes in Group 1 and Group 2 (p = 0.571, 0.741 for average, respectively). The amount of time after the onset of the disease ranged from 6.0 to 48 months (23.86 ± 16.70 months) in Group 1 and from 1 to 30 days (7.45 ± 8.86 days) in Group 2. There was no correlation between the CTs and follow-up times in Group 1 (p = 0.768 for average) and no association between the CTs and the thicknesses of the retinal nerve fibre layers in Group 2 (p = 0.453 for average). CT is not directly influenced by NAION at either the acute or the chronic stage of the disease. These results may also demonstrate that the changes of CT do not increase the risk of experiencing a NAION attack. ARTICLE HISTORY

Section: Discussionmentioning

confidence: 99%

Evaluation of Choroidal Thickness in Non-arteritic Anterior Ischaemic Optic Neuropathy at the Acute and Chronic Stages

Gonul

Gedik

Köktekir

et al. 2016

“…Papchenko et al 7 showed that both macular thickness and volume parameters are correlated with visual sensitivity, using Stratus OCT and Humphrey automated perimetry in NAION. Aggarwal et al 4 stated that pRNFL and macular GCL losses correlated well with VF losses in both magnitude and location.…”

Section: Discussionmentioning

confidence: 99%

“…This is different from the previous studies. 4,7 Generally, early superior disc oedema accompanies inferior field defect with decreased superior GCL þ IPL thickness. In our case, a disagreement between the area of early increased disc oedema and GCL þ IPL thickness decrease was observed.…”

Section: Discussionmentioning

confidence: 99%

Lack of Correspondence between Early Optic Disc Oedema and Macular Ganglion Cell Loss in Non-arteritic Anterior Ischaemic Optic Neuropathy

Park

Heo

et al. 2014

A 73-year-old Asian male presented with a 2-week history of acute visual disturbance in his right eye. Visual acuity in his right eye was hand movement and fundus examination showed right optic disc oedema and splinter haemorrhages on the disc margin. Each time the patient visited our clinic, spectral domain optical coherence tomography (OCT) was performed. He was diagnosed to have non-arteritic anterior ischaemic optic neuropathy. Optical coherence tomography showed disagreement between the areas of early peripapillary retinal nerve fibre layer thickening and macular ganglion cell layer thickness reduction.

“…5 Defects in the RNFLT have been observed in NAION. [6][7][8][9][10] The RGC layer is more than 1 cell layer thick at the macula (cell density up to 4-6 cell bodies thick); therefore, it was proposed that loss of retinal ganglion cells and nerve fibre layer can be reflected by a reduction in macular and central retinal thickness. NAION eyes were shown to have maculae that were thinner and smaller in volume than those of uninvolved eyes.…”

Section: Introductionmentioning

confidence: 99%

“…NAION eyes were shown to have maculae that were thinner and smaller in volume than those of uninvolved eyes. 10 Recently, in addition to macular thickness map, a posterior pole scan has been introduced in the Spectralis SD-OCT (Heidelberg Engineering, Heidelberg, Germany), which displays the retinal thickness over the entire posterior pole (30 Â 25 OCT volume scan). Of particular interest, therefore, is whether posterior pole retinal thickness (PPRT) correlates well with visual field (VF) thresholds (differential light sensitivity).…”

Section: Introductionmentioning

confidence: 99%

Posterior Pole Retinal Thickness for Detection of Structural Damage in Anterior Ischaemic Optic Neuropathy

Fard

Fakhree

Alipour

2013

This objectives of this study were to compare posterior pole retinal thickness (PPRT) and peripapillary retinal nerve fibre layer thickness (RNFLT) between the affected eyes of patients with previous nonarteritic anterior ischaemic optic neuropathy (NAION) and their unaffected eyes and to assess the structure-function relationship. Eighteen eyes with NAION and 14 contralateral unaffected eyes were included in this crosssectional study. Humphrey visual field (VF) sensitivities were obtained. RNFLT (six sectors) and PPRT (four quadrants) were measured with spectral-domain optical coherence tomography (Spectralis; Heidelberg Engineering, Heidelberg, Germany). These parameters were compared between both eyes of patients with unilateral NAION. The correlation of RNFLT and PPRT with VF mean sensitivity (MS) values (linear units) was also analysed. The main outcome measure was the correlation of MS values with PPRT and RNFLT. A significant difference existed between the affected eyes and the unaffected fellow eyes in the MS values, all sectors of RNFLT, and all quadrants of PPRT. A significant linear correlation was observed between RNFLT and PPRT and corresponding MS values in global and regional measures. The strongest correlation was between inferior temporal VF and its corresponding superior nasal retinal quadrant thickness. The area under the receiver operator characteristic curves comparing superior nasal PPRT and RNFLT between the normal and affected eyes was 0.97 and 0.96, respectively. The results show that PPRT and RNFLT provide equivalent performance to detect structural damage in ischaemic optic neuropathy.