Macular Thickness in Highly Myopic Children Aged 3 to 7 Years

Ziylan, Sule; Kızıloğlu, Özge Yabaş; Yenerel, Nursal Melda; Gokce, Berna; Çiftçi, Faruk

doi:10.3928/01913913-20150526-01

Cited by 6 publications

(18 citation statements)

References 28 publications

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“…To date, the relationship between RT and progression of myopia in children remains elusive. Some studies demonstrated that foveal RT was significantly decreased in highly myopic subjects [40], and some studies found that increasing axial myopia was associated with increased foveal RT and reduced parafoveal and perifoveal RT [37], or quadrant-specific RT [41,42], while others reported the absence of any association [43]. The current study found no significant correlation between baseline RT and baseline AL or SE.…”

Section: Discussioncontrasting

confidence: 65%

Short-Term Effects of Atropine 0.01% on the Structure and Vasculature of the Choroid and Retina in Myopic Chinese Children

et al. 2022

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Introduction: To explore the short-term effects of atropine 0.01% on the structure and vasculature of the choroid and retina in myopic Chinese children. Methods: This study was a single-center randomized clinical trial. A total of 40 subjects with myopia \ -6.0 D were enrolled and randomized to receive atropine 0.01% once nightly with regular single-vision lenses or to simply wear regular single-vision lenses at an allocation ratio of 1:1. Follow-up visits were planned at 1 month and 3 months. Choroidal thickness (ChT) was obtained by optical coherence tomography (OCT). Retinal vessel density (RVD), retinal thickness (RT), foveal avascular zone (FAZ) and choriocapillaris flow (CCF) were measured by optical coherence tomography angiography (OCTA). The RVD and RT were measured at fovea, parafovea and perifovea area and four quadrants.Results: Twenty-one subjects were allocated into the atropine group and 19 subjects into the control group. Over 3 months, the control group showed greater progression of myopia than those in the atropine group. ChT in the atropine group increased 11.12 ± 13.96 lm, which was not significant compared with that of the control group. None of the retinal sectors in atropine-treated eyes showed significant changes of RT and RVD compared with the control group. Besides, FAZ and CCF of the atropine group were not affected by atropine use over time, and there was no difference between the two groups. Conclusion: Administration of atropine 0.01% eye drops demonstrated no effect on RVD, FAZ and CCF over 3 months, while a modest increase of ChT was observed in atropine-treated eyes. Trial Registration Number: ChiCTR1800017154.

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Section: Discussioncontrasting

confidence: 65%

Short-Term Effects of Atropine 0.01% on the Structure and Vasculature of the Choroid and Retina in Myopic Chinese Children

et al. 2022

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“…Previous investigations mainly explored the effect of myopia on macular thickness, with variable results. 28,29,30,31,32 Although these studies used various methods to measure macular thickness, they generally found that macular thinning was associated with increasing myopia, and that it mainly occurred in the inner and outer maculae rather than at the central macula. 28,32 It has been reported in several studies that the central macular thickness becomes thicker with increasing myopia 28,32 or that it did not change.…”

Section: Discussionmentioning

confidence: 99%

Macular thicknesses and their associations with ocular and demographic variables in black South Africans

Mashige

Oduntan

2017

African Vision and Eye Health

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Purpose: To determine normal macular thicknesses and their associations with demographic and ocular variables in healthy eyes of black South Africans.Methods: Six hundred healthy subjects (N = 600) underwent height and weight measurements followed by a complete ophthalmic examination, which included auto-refraction, subjective refraction, slit-lamp biomicroscopy, ocular biometric measurements and tonometry. Intraocular pressure (IOP) was measured with the Nidek NT530P (Tonopachy™) and the axial length (AL) thickness with the Nidek Echoscan. The central corneal thickness (CCT) and macular thickness were measured using iVue-100 spectral-domain optical coherence tomography (Optovue, Inc.). The macular thickness map protocol that divides the macular area into nine regions of the Early Treatment Diabetic Retinopathy Study (ETDRS) fields was used. Variations in macular thickness measurements with body mass index (BMI), age, gender, refraction, AL, CCT and IOP were determined with partial correlation analysis.Results: The 600 subjects had a mean age of 28.15 ± 13.09 years (range = 10–66 years), with 305 (50.83%) being males and 295 (49.17%) females. The thickness values of the central, inner and outer maculae were normally distributed, with means of 235.89 µm ± 20.04 µm, 303.56 µm ± 18.68 µm and 287.81 µm ± 14.61 µm, respectively. Mean total macular thickness for all subjects was 268.72 ± 15.04 µm. The temporal quadrant was markedly thinner than all other quadrants for both inner and outer macular regions. Macular thicknesses were greater in men than in women (p < 0.05). The thickness of mean central, mean inner and mean outer maculae increased significantly with increasing BMI (p < 0.001). Central, inner and outer maculae were significantly associated (p < 0.001) with a high hyperopic spherical equivalent refraction. AL was associated with a thin inner macula (p < 0.05) and an outer macula (p < 0.001), but not with a thinner central macula (p > 0.05). Age, CCT and IOP were not associated with macular thickness values in any quadrant (p > 0.05).Conclusion: The macular values were thinner in women than in men and were related to BMI, gender, hyperopic spherical refraction and AL with regional variations. These differences should be considered when interpreting optical coherence tomography results for accurately diagnosing and managing retinal abnormalities.

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“…This was similar to the study of Choi and Lee [ 25 ]. Ziylan et al [ 26 ] compared the macular thicknesses of highly myopic children with healthy controls and found that foveal thickness was significantly greater in the high myopia group and parafoveal thicknesses of the inner and outer circles were significantly thinner in the high myopia group. However, in the studies of Barrio-Barrio et al [ 6 ] and Al-Haddad et al [ 27 ], no correlation between macular thickness and refraction was reported.…”

Section: Discussionmentioning

confidence: 99%

Macular Thickness Assessed with Optical Coherence Tomography in Young Chinese Myopic Patients

Zhao

et al. 2015

Journal of Ophthalmology

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Purpose. To evaluate the variations in macular thickness in young Chinese myopic persons and the association with axial length (AL), spherical equivalence refraction (SE), age, intraocular pressure, and sex. Methods. In total, 133 young Chinese myopic subjects between 18 and 30 years of age were selected. The macular thickness was assessed using third-generation optical coherence tomography. AL, intraocular pressure, and SE were also measured. Results. The mean central foveal thickness was 191.1 ± 15.3 µm. The macula was consistently thinner in women than in men. Central foveal thickness had a significant positive correlation with AL and a negative correlation with SE. In the inner and outer regions, the macular thickness had a positive correlation with SE and negative correlation with AL. Conclusions. The retina was thinner in women than in men. Associated with myopic progression and AL extension, the central foveal thickness increased, while the retinal thickness of the inner and outer regions decreased.

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Macular Thickness in Highly Myopic Children Aged 3 to 7 Years

Abstract: Anatomic changes in the retina occur even in young children with high myopia. Macular thickness characteristics of highly myopic children may influence the interpretation of data obtained with OCT.

Cited by 6 publications

References 28 publications

Short-Term Effects of Atropine 0.01% on the Structure and Vasculature of the Choroid and Retina in Myopic Chinese Children

Short-Term Effects of Atropine 0.01% on the Structure and Vasculature of the Choroid and Retina in Myopic Chinese Children

Macular thicknesses and their associations with ocular and demographic variables in black South Africans

Macular Thickness Assessed with Optical Coherence Tomography in Young Chinese Myopic Patients

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