Macular Pigment Optical Density Measured by Dual-Wavelength Autofluorescence Imaging in Diabetic and Nondiabetic Patients: A Comparative Study

Lima, Verônica Castro; Rosen, Richard B.; Maia, Maurício; Prata, Tiago S.; Dorairaj, Syril; Farah, Michel Eid; Sallum, Juliana Maria Ferraz

doi:10.1167/iovs.09-4695

Cited by 44 publications

(58 citation statements)

References 41 publications

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“…Paradoxically, despite their lower MPOD, metabolic control appeared better, diabetes duration was shorter, and DR prevalence was lower for Type 2 compared with Type 1 diabetic subjects. Although HbA1c has previously been shown to be inversely and significantly related to MPOD among a smaller sample of Type 2 diabetic subjects, 4 our findings imply that lower MPOD in Type 2 diabetes is not attributable to the diabetic condition, duration, or level of control, and suggests a need to explore alternative explanatory causes.…”

Section: Discussioncontrasting

confidence: 66%

“…It has been shown, for example, that Type 2 diabetic subjects had lower MPOD when compared with nondiabetic controls, while Type 2 diabetes with mild nonproliferative retinopathy exhibited similar MPOD levels to Type 2 diabetes without retinopathy. 4 In addition, serum lutein and zeaxanthin concentrations, which have been shown to be positively and significantly related to MPOD in normal subjects, 30 have been shown to be significantly lower in diabetes compared with normal subjects. 5 In more advanced cases of diabetic eye disease, subjects with Grade 2 maculopathy were found to have significantly lower MPOD than those without maculopathy.…”

Section: Discussionmentioning

confidence: 98%

“…1 Although the relationship between age-related macular degeneration and macular pigment optical density (MPOD) has been widely reported, 2,3 only a small number of studies have focused on MPOD and carotenoid intake in diabetes mellitus, 4,5 a condition similarly known to cause oxidative damage in the retina. 6 Diabetes, a lifelong progressive disease, is the result of the body's inability to produce insulin or use insulin to its full potential and is characterized by high circulating glucose.…”

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confidence: 99%

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Macular Pigment Optical Density Is Lower in Type 2 Diabetes, Compared With Type 1 Diabetes and Normal Controls

Scanlon¹,

Connell

Ratzlaff

et al. 2015

Retina

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

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Macular Pigment Optical Density Is Lower in Type 2 Diabetes, Compared With Type 1 Diabetes and Normal Controls

Scanlon¹,

Connell

Ratzlaff

et al. 2015

Retina

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“…MPOD values were higher while HbA1c levels were lower in nondiabetic subjects than diabetics. It can be considered that impaired glycemic control could cause defects in retinal absorption and dispersion of lutein and zeaxanthin [89].…”

Section: Role Of Lutein and Zeaxanthin In Diabetic Retinopathymentioning

confidence: 99%

An Overview on the Role of Macular Xanthophylls in Ocular Diseases

Sarıaltın¹,

Çoban²

2018

Rec.Nat.Prod.

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Macula lutea, is the center of the retina of the eye, contains high concentrations of lutein and zeaxanthin which can act as a filter against short-wavelength (blue) light. Lutein and zeaxanthin are the only carotenoids detected in human lens which exhibit highly strong free radical scavenging activity. Many epidemiological studies, clinical trials, animal experiments have suggested that lutein and zeaxanthin have antiinflammatory potential with their high antioxidant properties. Several eye diseases including, age-related macular degeneration, uveitis and retinitis pigmentosa are caused by ocular inflammation. Some studies have shown that lutein and zeaxanthin could be protective, curative and preventive against ocular inflammation induced diseases and other ocular disorders such as cataract, glaucoma and choroideremia. The mechanisms responsible for these effects are absorption of near-ultraviolet and blue light, reduction of oxidative stress, inflammation and angiogenesis. Lutein and zeaxanthin can be taken from dietary supplements or a diet high in fruits, vegetables such as kale, spinach and turnip greens. The aim of this review is to evaluate the relationship between the consumption of lutein and zeaxanthin and eye diseases.

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“…[21][22][23] A quantitative comparison of MPOD in diabetic and non-diabetic patients has recently been performed by Lima and co-workers. 24 We hypothesised that qualitative evaluation of 514 nm FAF and MPOD could provide additional useful information in the assessment of DMO. Thus, the purpose of this study was (1) to compare the sensitivity and specificity of two-wavelength FAF and MPOD imaging for the detection of DMO in patients with diabetic retinopathy and (2) to systematically describe characteristic FAF and MPOD appearances in DMO and consider the possible causes for these.…”

Section: Introductionmentioning

confidence: 99%

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema

Waldstein

Hickey

Mahmud

et al. 2012

Eye

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Purpose To evaluate the application of 488 and 514 nm fundus autofluorescence (FAF) and macular pigment optical density (MPOD) imaging in diabetic macular oedema (DMO) and to demonstrate the typical imaging features. Patients and Methods A hundred and twentyfive eyes of 71 consecutive patients with diabetic retinopathy who underwent examination at a specialist university clinic employing a modified Heidelberg Retina Angiograph, using two different light sources of 488 and 514 nm wavelength, were retrospectively reviewed. MPOD images were calculated using modified Heidelberg Eye Explorer software. All images were evaluated by two independent masked graders. Features from FAF and MPOD images were correlated with optical coherence tomography (OCT) imaging findings and inter-grader variability, sensitivity and specificity were calculated using OCT as reference. Results Sixty-seven eyes had DMO on OCT. The inter-grader variability was 0.84 for 488 nm FAF, 0.63 for 514 nm FAF and 0.79 for MPOD imaging. Sensitivity and specificity for detection of DMO were 80.6 and 89.7% for 488 nm FAF; 55.2 and 94.8% for 514 nm FAF; and 80.6 and 91.4% for MPOD imaging. In 488 nm FAF and MPOD imaging, DMO was better visualised in comparison with 514 nm FAF imaging, Po0.01. MPOD revealed displacement of macular pigment by intraretinal cysts. Conclusion MPOD imaging, and particularly its combination with 488 nm and 514 nm FAF, provides a valuable addition to OCT in the evaluation of DMO and is clinically useful in rapid en-face assessment of the central macula.

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Macular Pigment Optical Density Measured by Dual-Wavelength Autofluorescence Imaging in Diabetic and Nondiabetic Patients: A Comparative Study

Abstract: Type 2 diabetic patients, with or without retinopathy, had reduced MPOD when compared with that in nondiabetic patients. In addition, a significant inverse correlation between MPOD and HbA1C levels was observed.

Cited by 44 publications

References 41 publications

Macular Pigment Optical Density Is Lower in Type 2 Diabetes, Compared With Type 1 Diabetes and Normal Controls

Macular Pigment Optical Density Is Lower in Type 2 Diabetes, Compared With Type 1 Diabetes and Normal Controls

An Overview on the Role of Macular Xanthophylls in Ocular Diseases

Two-wavelength fundus autofluorescence and macular pigment optical density imaging in diabetic macular oedema

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