Macular morphology in former preterm and full-term infants aged 4 to 10 years

Fieß, Achim; Janz, Johannes; Schuster, Alexander K.; Kölb-Keerl, Ruth; Knuf, Markus; Kirchhof, Bernd; Muether, Philipp S.; Bauer, Jacqueline

doi:10.1007/s00417-017-3662-5

Cited by 53 publications

(71 citation statements)

References 36 publications

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“…The HEIDELBERG EYE EXPLORER segmentation software (Version 6.0.7.0; Heidelberg Engineering GmbH) was used to measure the thickness of the total foveal retinal layer (TR) (Fieß et al 2017b). The deepest foveal depression was assumed to be the foveal centre.…”

Section: Spectral Domain Oct Image Acquisition and Analysismentioning

confidence: 99%

“…The deepest foveal depression was assumed to be the foveal centre. The HEIDELBERG EYE EXPLORER segmentation software (Version 6.0.7.0; Heidelberg Engineering GmbH) was used to measure the thickness of the total foveal retinal layer (TR) (Fieß et al 2017b).…”

Section: Spectral Domain Oct Image Acquisition and Analysismentioning

confidence: 99%

“…Furthermore, McLoone et al (2006) observed a hypoplastic optic nerve via RetCam (Clarity Medical Systems) in preterm infants with stage IV intraventricular bleeding imaged at 33-34 weeks of GA. In addition, it is well-known that prematurity and ROP also cause developmental alterations of the macula, leading to retinal thickening in the fovea in childhood ( Akerblom et al 2012;Fieß et al 2017b;Molnar et al 2017). However, it is remarkable that neither pRNFL nor total foveal retinal thickness measured at the age of 4-10 years were associated with neurologic development in multivariable analysis at 2 years of age.…”

Section: Changes In the Optic Nervementioning

confidence: 99%

“…Indeed, Rothman et al (2015) reported an association between pRNFL and brain structure as well as neurodevelopment changes in preterm infants versus full-term infants. Moreover, because prematurity can also cause disturbed development processes in the macula, these changes may also be associated with impeded visual function (Bowl et al 2016;Fieß et al 2017b). Furthermore, in the WPS, an association between pRNFL thinning and reduced visual acuity was found (Fieß et al 2017a).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is of interest if these pRNFL measurements reveal information about infants' neurologic development. Moreover, because prematurity can also cause disturbed development processes in the macula, these changes may also be associated with impeded visual function (Bowl et al 2016;Fieß et al 2017b). Consequently, it is of clinical importance to investigate if pRNFL and/or macula changes are associated with neurological development.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Fieß

Kölb-Keerl

Schuster³

et al. 2018

Acta Ophthalmologica

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Section: Spectral Domain Oct Image Acquisition and Analysismentioning

confidence: 99%

Section: Spectral Domain Oct Image Acquisition and Analysismentioning

confidence: 99%

Section: Changes In the Optic Nervementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Fieß

Kölb-Keerl

Schuster³

et al. 2018

Acta Ophthalmologica

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Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity

et al. 2022

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IMPORTANCEPreterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes.OBJECTIVE To evaluate the association between preterm infant retinal microanatomy and VA at 9 months' corrected age. DESIGN, SETTING, AND PARTICIPANTSThis prospective observational study took place from November 2016 and December 2019 at a single academic medical center and included preterm infants enrolled in Study of Eye Imaging in Preterm Infants (BabySTEPS). Infants were eligible for enrollment in BabySTEPS if they met criteria for retinopathy of prematurity (ROP) screening, were 35 weeks' postmenstrual age or older at the time of first OCT imaging, and a parent or guardian provided written informed consent. Of 118 infants enrolled in BabySTEPS, 61 were included in this analysis. Data were analyzed from March to April 2021. EXPOSURES Bedside optical coherence tomography (OCT) imaging at a mean (SD) 39.85 (0.79) weeks' postmenstrual age and monocular grating VA measurement at 9 months' corrected age. MAIN OUTCOMES AND MEASURESPresence and severity of macular edema and presence of ellipsoid zone at the fovea measured by extracting semiautomated thicknesses of inner nuclear layer, inner retina, and total retina at the foveal center; choroid across foveal 1 mm; and retinal nerve fiber layer (RNFL) across the papillomacular bundle (PMB). Pearson correlation coefficients were calculated and 95% CIs were bootstrapped for the association between retinal layer thicknesses and continuous logMAR VA. Associations were analyzed between retinal microanatomy and normal (3.70 cycles/degree or greater) vs subnormal grating VA at 9 months' corrected age using logistic regression and with logMAR VA using linear regression, adjusting for birth weight, gestational age, and ROP severity at the time of OCT imaging and accounting for intereye correlation using generalized estimating equations. RESULTSThe mean (SD; range) gestational age of included infants was 27.6 (2.8; 23.0-34.6) weeks, and mean (SD; range) birth weight was 958.2 (293.7; 480-1580) g. In 122 eyes of 61 infants, the correlations between retinal layer thicknesses and logMAR VA were as follows: r, 0.01 (95% CI, −0.07 to −0.27) for inner nuclear layer; r, 0.19 (95% CI, 0.01 to 0.35) for inner retina; r, 0.15 (95% CI, −0.02 to 0.31) for total retina; r, −0.22 (95% CI, −0.38 to −0.03) for choroid; and r, −0.27 (95% CI, −0.45 to 0.10) for RNFL across the PMB. In multivariable analysis, thinner RNFL across the PMB (regression coefficient, −0.05 per 10-μm increase in RNFL thickness; 95% CI, −0.10 to −0.01; P = .046) and prior ROP treatment (regression coefficient, 0.33 for ROP treatment; 95% CI, 0.11 to 0.56; P = .003) were independently associated with poorer 9-month logMAR VA. CONCLUSIONS AND RELEVANCEIn preterm infants, RNFL thinning across the PMB was associated with poorer 9-month VA, independent of birth weight, gestational age, need for ROP treatment, and macular microanatom...

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Ophthalmological long-term sequelae of premature birth—Persisting into adulthood

et al. 2023

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Macular morphology in former preterm and full-term infants aged 4 to 10 years

Cited by 53 publications

References 36 publications

Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Correlation of morphological parameters and visual acuity with neurological development in former preterm children aged 4–10 years

Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity

Ophthalmological long-term sequelae of premature birth—Persisting into adulthood

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