Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study

Gutierrez-Bonet, R.; Ruiz‐Medrano, Jorge; Peña-García, Pablo; Catanèse, M.; Sadeghi, Y; Hashemi, Katayoon; Gabison, Éric; Ruiz-Moreno, José M.

doi:10.1167/tvst.7.3.15

Cited by 33 publications

(63 citation statements)

References 43 publications

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“…The median age was 24.00 years (range [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] and individuals in our sample were predominately men (76.3%). Median best corrected visual acuity (BCVA) was 0.90 Snellen (range 0.10-1.00), with glasses or contact lenses.…”

Section: Resultsmentioning

confidence: 86%

Increased choroidal thickness is not a disease progression marker in keratoconus

Pinheiro-Costa

Correia

Pinto

et al. 2020

Sci Rep

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The recent findings of increased Choroidal Thickness (CT) in Keratoconus (KC) patients raised the question of whether CT could be an indicator of progressive KC. To test this hypothesis, we evaluated and compared the choroidal profile in progressive and non-progressive KC. We ran a cross-sectional observational study in 76 patients diagnosed with KC, age 14–30, to assess KC progression. Progression was defined as when at least two of the studied variables confirmed progression (Kmax, Km, PachyMin, D-Index, Astig, K2, 3 mm PCR). Included patients performed a Spectralis Optical Coherence Tomography (OCT) with enhanced depth image (EDI) technology to evaluate choroidal profile. Choroidal measurements were taken subfoveally and at 500 µm intervals from the fovea, in 7 different locations, and compared between groups. Multivariate linear regression analyses were also performed to assess the influence of CT in KC progression. Thirty-six eyes (47.4%) were classified as KC progressors. The mean subfoveal CT observed in the total sample was 382.0 (± 97.0) μm. The comparison between groups (progressive and non-progressive KC) showed no differences in the locations evaluated (mean subfoveal CT difference between groups was 2.4 μm, p = 0.915). In the multivariate analysis CT seems not be influenced by KC progression (B = 6.72 μm, 95% CI − 40.09 to 53.53, p = 0.775). Assessment of choroidal profile does not appear to be a useful tool to differentiate progressive and non-progressive KC. Further research is needed in order to better understand the role of choroid in KC.

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Section: Resultsmentioning

confidence: 86%

Increased choroidal thickness is not a disease progression marker in keratoconus

Pinheiro-Costa

Correia

Pinto

et al. 2020

Sci Rep

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“…Changes in CT profile in KC patients have already been described [21]. However, the exact changes taking place in the choroid itself are still unclear.…”

Section: Discussionmentioning

confidence: 96%

“…e main problem is thought to be related to collagen type I fibre degradation by metalloproteinases (MMP) [17]. Latest theories about KC hint to a possible inflammatory component in the pathology of this disease and that might explain the increase in their CT profile compared with healthy population [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Choroidal Vascularity Index in Keratoconus Patients Using Swept-Source Optical Coherence Tomography-Based Binarization Techniques

Gutierrez-Bonet

Ruiz‐Medrano

Biarnés

et al. 2020

Journal of Ophthalmology

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Purpose. To analyse the vascular density of the choroid in a keratoconus (KC) population using swept-source optical coherence tomography (SS-OCT). Methods. Prospective, noninterventional study that analysed 97 eyes from 52 KC patients and 145 eyes from 89 healthy controls. The sample was divided in four different age groups. Inclusion criteria were topographic diagnosis of KC using Pentacam, axial length shorter than 26 mm, good quality of the images, and no other systemic or ocular diseases. A 12 mm horizontal single-line SS-OCT b-scan was performed to create a choroidal thickness (CT) profile. Validated automated segmentation and binarization were used in order to analyse choroidal, stromal, and vascular areas. Results. The percentage of choroidal vascularity (vascular area/total area) was 56.6% in KC patients vs. 49.4% in controls. Aged-adjusted choroidal, stromal, and vascular areas and corrected choroidal percentage of vascularity are statistically increased in KC patients when compared with healthy controls (p<0.001). All these parameters show a decreasing trend with age. Both stromal and vascular areas were thicker in KC patients (p<0.001). Conclusions. Choroidal, stromal, and vascular areas and corrected choroidal percentage of vascularity are statistically increased in KC patients when compared with healthy controls. All these parameters tend to decrease with age.

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“…Interestingly, KCN is not associated with marked axial elongation [ 23 , 24 ]. Furthermore, it has been reported that choroidal thickness is increased in patients younger than 45 years old with KCN [ 25 ]. The observed higher frequency of KCN in our DSM patients warrants further investigation to determine if there is an association in terms of pathological disease process.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal follow-up of dome-shaped macula

Burke

Shen

et al. 2020

Eye

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Background/objectives To determine if the presence of sub-retinal fluid (SRF) was associated with reduced vision in dome-shaped macula (DSM), and to assess its effect and response to treatment during follow-up. Methods Patients were identified retrospectively. Baseline and follow-up data were recorded. The diagnosis of DSM, and presence or absence of SRF and intra-retinal fluid (IRF) was confirmed using Spectral Domain-Optical Coherence Tomography (SD-OCT). Decisions to treat oedema were based on clinician preference. Results 193 eyes of 106 patients (71 female) were confirmed to have DSM. Overall mean duration of follow-up for this cohort was 3.5 years. Mean BRVA for all eyes at baseline was 0.38 (range: −0.20 to ‘light perception’). A significant difference was noted in mean baseline BRVA between those eyes with SRF compared with those without SRF at baseline (0.48 vs. 0.31, p < 0.001). Intra-retinal fluid moderately correlated with poorer baseline BRVA ( r = 0.31, p < 0.003). No significant change in BRVA was noted during follow-up. No significant effect of treatment on BRVA was observed. Conclusions The presence of SRF at baseline was associated with poorer vision. Vision appears to remain stable irrespective of the presence or absence of SRF at baseline. The treatments administered in this cohort did not affect final vision or SRF.

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Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study

Cited by 33 publications

References 43 publications

Increased choroidal thickness is not a disease progression marker in keratoconus

Increased choroidal thickness is not a disease progression marker in keratoconus

Analysis of Choroidal Vascularity Index in Keratoconus Patients Using Swept-Source Optical Coherence Tomography-Based Binarization Techniques

Longitudinal follow-up of dome-shaped macula

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