Macroscopic Serosal Classification Predicts Peritoneal Recurrence for Patients with Gastric Cancer Underwent Potentially Curative Surgery

Sun, Zhe; Xu, Yingying; Wang, Zhenning; Zhu, Zhi; Zhang, Hao; Huang, Baojun; Xu, Yan; Chen, Junqing

doi:10.1245/s10434-010-1449-6

Cited by 30 publications

(26 citation statements)

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“…Serosal invasion was consistently reported as a significant risk factor for peritoneal recurrence [3,21,22], and some authors have reported that gastric cancer patients with serosal invasion have shown significant improvement in survival when treated with IPC in randomized controlled studies [10,23]. Similar to previous studies, the present study showed that depth of tumor invasion was the most important risk factor regardless of adjuvant chemotherapy administration.…”

Section: Discussionsupporting

confidence: 86%

Factors predicting peritoneal recurrence in advanced gastric cancer: implication for adjuvant intraperitoneal chemotherapy

et al. 2013

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Background Despite adjuvant chemotherapy, patients with advanced gastric cancer (AGC) often develop recurrence, and the peritoneum is the most common site of recurrence. Therefore, intraperitoneal chemotherapy (IPC) has been proposed as a treatment option. The aim of this study was to select the eligible patients for application of IPC. The first site of recurrence was the peritoneum in 144 patients (58.8 %), and the 5-year peritoneal recurrence-free survival was 79.3 %. Depth of tumor invasion CT3, extensive lymph node metastasis (N3), Bormann type 4, infiltrative type (Ming's classification), and venous invasion were independent risk factors for peritoneal recurrence. In subgroup analysis with patients who had received adjuvant chemotherapy (n = 481), depth of tumor invasion CT3, Bormann type 4, infiltrative type (Ming's classification), and venous invasion were independent risk factors for peritoneal recurrence. When a peritoneal recurrence risk index was made with each risk factor assigned 1 point (2 points for T4 stage), peritoneal recurrence rates with 0, 1, 2, 3, 4, or 5 points were 0 %, 3.9 %, 13.1 %, 33.3 %, 44.0 %, and 72.0 %, respectively, in those patients. Conclusions Patients at higher risk for peritoneal recurrence can be identified from the findings of this study. Further prospective studies are required to evaluate the usefulness of IPC for these patients.

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Section: Discussionsupporting

confidence: 86%

Factors predicting peritoneal recurrence in advanced gastric cancer: implication for adjuvant intraperitoneal chemotherapy

et al. 2013

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“…In this study, we observed the expression of βig-h3 in peritoneal mesothelial cells and the positive rate of βig-h3 was significantly higher in the more invasive and advanced serous-type subgroups. Previously, the depth of invasion and the serosal changes were reported to be significant risk factors for the prediction of peritoneal recurrence (15,17). Thus, we proposed the hypothesis that the βig-h3 expression in peritoneal mesothelial cells in gastric cancer patients may be a marker of the biological behavior of gastric cancer and could predict peritoneal metastasis.…”

Section: Discussionmentioning

confidence: 95%

“…(15). The peritoneal tissues were directly obtained from the surgical site and immediately fixed in 10% buffered formalin and then embedded in paraffin.…”

Section: Introductionmentioning

confidence: 99%

βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis

Zhang

Jin

et al. 2012

Molecular Medicine Reports

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Abstract. βig-h3 is an extracellular matrix protein and its expression is highly induced by transforming growth factor (TGF-β). It has also been suggested to play an important role in the growth and invasion of colon and pancreatic cancers. In the present study, we demonstrated that βig-h3 is expressed in mesothelial cells, especially in patients with advanced gastric cancer. The positive rate of βig-h3 was significantly higher in cases with a more invasive and advanced serous-type, with visible peritoneal metastasis, and in peritoneal lavage cytological examination (PLC) (+) and peritoneal lavage fluid CEA mRNA(+) subgroups (p<0.05). Our study also showed that the expression of βig-h3 gradually increased with increasing TGF-β1 concentrations in vitro in a time-dependant manner. In addition, βig-h3 also induced human gastric carcinoma cell line (SGC-7901) cell adhesion in a dose-dependent manner and significantly increased cell migration and proliferation. The results suggest that βig-h3 expression in peritoneal mesothelial cells in gastric cancer patients is a marker of the biological behavior of gastric cancer and plays an important role in the process of peritoneal carcinomatosis.

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“…Many studies of the status of tumor invasion at the invasive front have analyzed the changes in the serosal surface in gastric cancer invading the serosa (14)(15)(16). In one such study, the maximum diameter of the region with altered serosal surface was measured (16), and in another, the status of alteration of the serosal surface was classified according to macroscopic findings (15).…”

Section: Discussionmentioning

confidence: 99%

“…In one such study, the maximum diameter of the region with altered serosal surface was measured (16), and in another, the status of alteration of the serosal surface was classified according to macroscopic findings (15). The pattern of tumor infiltration into the surrounding tissue was investigated in serosa-negative advanced gastric cancer i.e.…”

Section: Discussionmentioning

confidence: 99%

inical Implication of the Width of Subserosal Invasion in T3N0 Gastric Cancer

Nakamura

Tomioku

Nabeshima

et al. 2017

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Abstract. Background: The aim of this study was to clarify the impact of the horizontal width of tumor invasion into the subserosal layer on prognosis in patients withIn Japan, gastric cancer is treated according to the Japanese gastric cancer treatment guidelines 2014 (1). According to the guidelines, the standard treatment for curatively resectable advanced gastric cancer with invasion of the subserosa (T3) and no lymph node metastasis (N0) is surgery alone. However, a certain proportion of these patients develop recurrence, and nearly all patients with recurrence die of their disease. Therefore, it is considered to be of crucial clinical importance to identify the subset of patients with poor prognosis in this group.Tumor diameter, lymphatic invasion, venous invasion, etc., have been considered as prognostic factors in patients with T3N0 gastric cancer (2-6). Opinions regarding the prognostic factors are divided, and no consensus has been reached. Therefore, in this study, we paid attention to the status of tumor invasion at the invasive front. Many studies of the status of tumor invasion at the invasive front have investigated changes in the serosal surface in patients with gastric cancer invading the serosa (7-10). However, there have been few studies investigating the status of tumor invasion into the subserosal layer in gastric cancer with invasion of the subserosa (11). Therefore, in the present study, we assessed the status of tumor invasion into the subserosal layer in T3N0 gastric cancer and investigated the possibility of its being a prognostic factor. Patients and MethodsPatients. Between January 2006 and December 2015, 884 consecutive patients with gastric cancer underwent curative gastrectomy at the Department of Gastroenterological Surgery of Tokai University School of Medicine. Of these patients, the data of 72 in whom the histological examination revealed pT3N0 were analyzed in this retrospective study. The gross classification and histopathological classification were based on the Japanese Classification of Gastric Carcinoma published by the Japanese Gastric Cancer Association (JCGC) (12). Staging was performed according to the American Joint Committee on Cancer staging manual seventh edition (13). Patients were mainly followed-up on an outpatient basis at our hospital; however, those who had moved to other institutions were asked relevant questions by telephone. Follow-up was continued until June 2016, with a median duration of follow-up of 1574 days (range=82-4373 days). Diagnosis of tumor recurrence was based on clinical grounds. In patients with suspected recurrence, further investigations were performed. In some patients, the initial recurrence was diagnosed at two or more sites, and in such patients, all of the sites were counted as sites of initial recurrence.Definition of width of subserosal invasion and clinicopathological parameters. The resected stomach was opened and placed on a flat board with the mucosal side up, and fixed in 10% formalin. After 409

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Macroscopic Serosal Classification Predicts Peritoneal Recurrence for Patients with Gastric Cancer Underwent Potentially Curative Surgery

Cited by 30 publications

References 30 publications

Factors predicting peritoneal recurrence in advanced gastric cancer: implication for adjuvant intraperitoneal chemotherapy

Factors predicting peritoneal recurrence in advanced gastric cancer: implication for adjuvant intraperitoneal chemotherapy

βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis

inical Implication of the Width of Subserosal Invasion in T3N0 Gastric Cancer

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