Macroporous membranes, I. Reactive macroporous membranes based on glycidyl methacrylate‐ethylene dimethacrylate copolymer for high‐performance membrane chromatography

Abstract

Macroporous membranes were prepared by the radical polymerization of the organic phase, carried out in bulk, opposite to the usually employed suspension radical synthesis of macroporous beads. The properties of the membranes, such as porosity, specific surface area, pore size and distribution and others, approach those of the beads and can be modified by using the same procedures. Water permeability of the membranes is the property important with respect to their application. Dependences of permeability on the polymerization time, concentration of the crosslinking agent in the polymerization mixture, membrane thickness and the polymerization procedure were determined. ZUSAMMENFASSUNG.Durch radikalische Polymerisation einer nicht suspendierten organischen Phase, die normalerweise bei der Herstellung von makroporosen sphtirischen Teilchen in einer Suspension benutzt wird, wurden direkt in einer Form makroporose Membranen hergestellt. Ihre Eigenschaften wie z. B. die Porositat, spezifische Oberflache, PorengroRe, PorengroDeverteilung u. a. ahneln denen makroporoser Teilchen und konnen auch durch dieselben Methoden beeinflufit werden. Fur die Anwendung der Membranen ist die Wasserdurchlassigkeit von besonderer Wichtigkeit. Die Abhlngigkeiten der Wasserdurchlassigkeit von der Polymerisationsdauer, der Vernetzungsmittelkonzentration im Polymerisationsansatz, der Membrandicke und der Polymerisationsart wurden ermittelt.

An Introduction to Monolithic Disks as Stationary Phases for High Performance Biochromatography

“…The breakthrough in HPMDC was the transfer of a technique (suspension polymerization) hitherto used for the production of porous beads, to the production of porous polymer blocks (monoliths) [11,12]. This had important consequences.…”

Biocompatible polymeric monoliths for protein and peptide separations

“…Major contributions have been made by Svec, FrØchet, and co-workers [9 -12], who initially developed radical polymerization systems for these purposes [18]. Polymer monolithic media represent uniformly structured matrices with large interpenetrating pores (usually in the low micrometer range), which provide unique advantages such as fast kinetics, high reactivity, and high throughput.…”

Macroporous Polyolefin Membranes from Dicyclopentadiene High Internal Phase Emulsions: Preparation and Morphology Tuning

“…They are also simple processes and have a low energy consumption . In particular, macroporous membranes offer attractive solutions in membrane chromatography as they are ideally suited for the recovery and purification of proteins on a laboratory as well as on an industrial scale . The mass transport of the media through a membrane depends largely on the membrane's porosity.…”

“…[1,2] In particular, macroporous membranes offer attractive solutions in membrane chromatography as they are ideally suited for the recovery and purification of proteins on a laboratory as well as on an industrial scale. [3,4] The mass transport of the media through a membrane depends largely on the membrane's porosity. Various techniques are possible to synthesise porous membranes, whereas phase separation (phase inversion) of organic polymers is the most commonly used approach towards microporous membranes.…”