Macrophages target <i>Listeria monocytogenes</i> by two discrete non-canonical autophagy pathways

Gluschko, Alexander; Farid, Alina; Herb, Marc; Grumme, Daniela; Krönke, Martin; Schramm, Michael

doi:10.1080/15548627.2021.1969765

Cited by 24 publications

(34 citation statements)

References 50 publications

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“…Most of the knowledge on LAP is based on genetic analyses of NOX2 and Rubicon, which also have LAP-independent roles in host defense and autophagy that complicate the interpretation of data. Furthermore, much remains to be discovered about the mechanisms downstream of NOX2 and Rubicon and about mechanisms independent of these two factors, especially because multiple pathways to single membrane LC3 lipidation seem to exist ( Mitchell et al., 2018 ; Rai et al., 2019 ; Fischer et al., 2020 , Gluschko et al, 2021 Wong et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…To summarize, LAP provides anti-Listeria immunity in macrophages, while PINCA, the LC3 recruitment to permeabilized phagosomes, does not restrict bacterial growth Herb et al, 2018;Mitchell et al, 2018;Gluschko et al, 2021). The host defense function of LAP is counteracted by bacterial LLO, the primary virulence factor that mediates invasion of the cytosol after phagocytosis, where L. monocytogenes has to defend itself against xenophagy (Seveau, 2014;Osborne and Brumell, 2017;Mitchell et al, 2018).…”

Section: Listeria Monocytogenesmentioning

confidence: 99%

“…Recent studies revealed that phagosome permeabilization by L. monocytogenes triggers another single membrane LC3 lipidation pathway, which has been named pore-forming toxin-induced non-canonical autophagy pathway (PINCA) ( Mitchell et al., 2018 ; Gluschko et al., 2021 ). In bone marrow-derived macrophages, L. monocytogenes was shown to be targeted sequentially by multiple autophagic processes.…”

Section: Interactions Of Bacterial Pathogens With Lapmentioning

confidence: 99%

“…However, this PINCA response had no role in restricting bacteria growth, in contrast to subsequent xenophagy, which defends against L. monocytogenes bacteria upon invasion of the cytosol ( Mitchell et al., 2018 ). PINCA is distinct from LAP, because it can occur in NOX2-deficient macrophages ( Gluschko et al., 2021 ). Induction of LAP in PINCA-competent cells confirmed that LAP contributes to host defense, while no clear anti- Listeria function of PINCA could be identified ( Gluschko et al., 2021 ).…”

Section: Interactions Of Bacterial Pathogens With Lapmentioning

confidence: 99%

“…PINCA is distinct from LAP, because it can occur in NOX2-deficient macrophages ( Gluschko et al., 2021 ). Induction of LAP in PINCA-competent cells confirmed that LAP contributes to host defense, while no clear anti- Listeria function of PINCA could be identified ( Gluschko et al., 2021 ).…”

Section: Interactions Of Bacterial Pathogens With Lapmentioning

confidence: 99%

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LAPped in Proof: LC3‐Associated Phagocytosis and the Arms Race Against Bacterial Pathogens

Grijmans

Kooij

Varela

et al. 2022

Front. Cell. Infect. Microbiol.

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Cells of the innate immune system continuously patrol the extracellular environment for potential microbial threats that are to be neutralized by phagocytosis and delivery to lysosomes. In addition, phagocytes employ autophagy as an innate immune mechanism against pathogens that succeed to escape the phagolysosomal pathway and invade the cytosol. In recent years, LC3-associated phagocytosis (LAP) has emerged as an intermediate between phagocytosis and autophagy. During LAP, phagocytes target extracellular microbes while using parts of the autophagic machinery to label the cargo-containing phagosomes for lysosomal degradation. LAP contributes greatly to host immunity against a multitude of bacterial pathogens. In the pursuit of survival, bacteria have developed elaborate strategies to disarm or circumvent the LAP process. In this review, we will outline the nature of the LAP mechanism and discuss recent insights into its interplay with bacterial pathogens.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Listeria Monocytogenesmentioning

confidence: 99%

Section: Interactions Of Bacterial Pathogens With Lapmentioning

confidence: 99%

Section: Interactions Of Bacterial Pathogens With Lapmentioning

confidence: 99%

Section: Interactions Of Bacterial Pathogens With Lapmentioning

confidence: 99%

See 3 more Smart Citations

LAPped in Proof: LC3‐Associated Phagocytosis and the Arms Race Against Bacterial Pathogens

Grijmans

Kooij

Varela

et al. 2022

Front. Cell. Infect. Microbiol.

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Autophagy as an innate immunity response against pathogens: a Tango dance

Aguilera,

Delgui,

Reggiori

et al. 2023

FEBS Letters

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Intracellular infections as well as changes in the cell nutritional environment are main events that trigger cellular stress responses. One crucial cell response to stress conditions is autophagy. During the last 30 years, several scenarios involving autophagy induction or inhibition over the course of an intracellular invasion by pathogens have been uncovered. In this review, we will present how this knowledge was gained by studying different microorganisms. We intend to discuss how the cell, via autophagy, tries to repel these attacks with the objective of destroying the intruder, but also how some pathogens have developed strategies to subvert this. These two fates can be compared with a Tango, a dance originated in Buenos Aires, Argentina, in which the partner dancers are in close connection. One of them is the leader, embracing and involving the partner, but the follower may respond escaping from the leader. This joint dance is indeed highly synchronized and controlled, perfectly reflecting the interaction between autophagy and microorganism.

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Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy

Wei,

Liu,

Meng

et al. 2024

Inflamm. Res.

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Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways

Cited by 24 publications

References 50 publications

LAPped in Proof: LC3‐Associated Phagocytosis and the Arms Race Against Bacterial Pathogens

LAPped in Proof: LC3‐Associated Phagocytosis and the Arms Race Against Bacterial Pathogens

Autophagy as an innate immunity response against pathogens: a Tango dance

Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy

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