Macrophage profile and homing into breast milk in response to ongoing respiratory infections in the nursing infant

Zheng, Yingying; Correa‐Silva, Simone; Souza, Eloísa Correa de; Rodrigues, Regina Maria; Fonseca, Fernanda Andrade Macaferri da; Gilio, Alfredo Elias; Carneiro‐Sampaio, Magda; Palmeira, Patrícia

doi:10.1016/j.cyto.2020.155045

Cited by 11 publications

(8 citation statements)

References 34 publications

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“…Breast milk macrophages (BrMM) represent up to 80% of colostrum and transitional HBM, showing their involvement in the immune protection of the infant ( 83 ). Recent data have confirmed the abundance of monocytes/macrophages in HBM and are grouped into inflammatory (CD16 − ) and non-inflammatory (CD16 + ) macrophages ( 84 – 87 ). Although a consistent number of monocytes/macrophages found in breast tissue are originated from the peripheral blood, the gut, or the nasopharynx-associated lymphoid tissues, a fraction is locally constituted in the mammary tissue ( 8 , 78 ).…”

Section: Cells Microvesicles and Molecules Found In Hbmmentioning

confidence: 87%

“…Zheng et al. reported that macrophages homing to breast, and are found in milk, in response to ongoing respiratory infections in the nursing infant, displayed an anti-inflammatory profile that correlated with protection of the infant against mucosal inflammation ( 84 ). Indeed, these breast macrophages of a mother are trafficking to the mucosal surfaces of the offspring in mice and other animal models ( 36 , 39 , 58 , 62 , 91 ).…”

Section: Cells Microvesicles and Molecules Found In Hbmmentioning

confidence: 99%

“…Indeed, these breast macrophages of a mother are trafficking to the mucosal surfaces of the offspring in mice and other animal models ( 36 , 39 , 58 , 62 , 91 ). Therefore, it is clear that these cells play a crucial role in the gastrointestinal mucosa and are involved in the maturation of the immune system of the nursing infant without causing inflammation ( 73 , 84 , 92 , 93 ). These breast-derived macrophages may therefore exert an important role in innate immunity but also triggering high antigen-specific T cells ( 89 ).…”

Section: Cells Microvesicles and Molecules Found In Hbmmentioning

confidence: 99%

“…( 228 ). These cytokines are primarily originated from the mammary glands, and include IL-1 β ( 229 , 230 ), IL-2 ( 229 ), IL-4 ( 230 ), IL-5 ( 230 ), IL-6 ( 84 , 229 – 231 ), IL-8 ( 232 ), IL-10 ( 189 , 230 ), IL-12 ( 233 ), IL-13 ( 230 , 233 ), TNFα ( 229 , 231 ), TGF (transforming growth factor)-β (232), IFN-γ (235), granulocyte-colony stimulating factor (G-CSF) ( 234 ), monocytes chemotactic protein 1 (MCP-1) ( 115 ) and Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted (RANTES) ( 93 , 230 ). Purified immune cells from HBM have been shown to be able of producing several cytokines ( 231 ).…”

Section: Cytokines/chemokines Profile Of Breast Milkmentioning

confidence: 99%

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Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers

et al. 2022

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Breastfeeding is associated with long-term wellbeing including low risks of infectious diseases and non-communicable diseases such as asthma, cancer, autoimmune diseases and obesity during childhood. In recent years, important advances have been made in understanding the human breast milk (HBM) composition. Breast milk components such as, non-immune and immune cells and bioactive molecules, namely, cytokines/chemokines, lipids, hormones, and enzymes reportedly play many roles in breastfed newborns and in mothers, by diseases protection and shaping the immune system of the newborn. Bioactive components in HBM are also involved in tolerance and appropriate inflammatory response of breastfed infants if necessary. This review summarizes the current literature on the relationship between mother and her infant through breast milk with regard to disease protection. We will shed some light on the mechanisms underlying the roles of breast milk components in the maintenance of health of both child and mother.

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Section: Cells Microvesicles and Molecules Found In Hbmmentioning

confidence: 87%

Section: Cells Microvesicles and Molecules Found In Hbmmentioning

confidence: 99%

Section: Cells Microvesicles and Molecules Found In Hbmmentioning

confidence: 99%

Section: Cytokines/chemokines Profile Of Breast Milkmentioning

confidence: 99%

See 2 more Smart Citations

Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers

et al. 2022

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“…Another recent study revealed that the macrophage profile in breast milk changes in response to ongoing respiratory infections in the nursing infant. The researchers observed increased frequencies of anti-inflammatory macrophages and higher IL-6 and IL-8 concentrations in the milk of mothers whose infants had an ongoing respiratory infection, indicating that the composition of breast milk changes according to the infant’s needs to ensure neonatal protection ( 252 ).…”

Section: The Importance Of Breast Milk For the Development Of The Neonatementioning

confidence: 99%

Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn

et al. 2021

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The innate immune system is the oldest protection strategy that is conserved across all organisms. Although having an unspecific action, it is the first and fastest defense mechanism against pathogens. Development of predominantly the adaptive immune system takes place after birth. However, some key components of the innate immune system evolve during the prenatal period of life, which endows the newborn with the ability to mount an immune response against pathogenic invaders directly after birth. Undoubtedly, the crosstalk between maternal immune cells, antibodies, dietary antigens, and microbial metabolites originating from the maternal microbiota are the key players in preparing the neonate’s immunity to the outer world. Birth represents the biggest substantial environmental change in life, where the newborn leaves the protective amniotic sac and is exposed for the first time to a countless variety of microbes. Colonization of all body surfaces commences, including skin, lung, and gastrointestinal tract, leading to the establishment of the commensal microbiota and the maturation of the newborn immune system, and hence lifelong health. Pregnancy, birth, and the consumption of breast milk shape the immune development in coordination with maternal and newborn microbiota. Discrepancies in these fine-tuned microbiota interactions during each developmental stage can have long-term effects on disease susceptibility, such as metabolic syndrome, childhood asthma, or autoimmune type 1 diabetes. In this review, we will give an overview of the recent studies by discussing the multifaceted emergence of the newborn innate immune development in line with the importance of maternal and early life microbiota exposure and breast milk intake.

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Regenerative Potential of Human Breast Milk: A Natural Reservoir of Nutrients, Bioactive Components and Stem cells

Kumari

Raval

Rana

et al. 2023

Stem Cell Rev and Rep

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Macrophage profile and homing into breast milk in response to ongoing respiratory infections in the nursing infant

Cited by 11 publications

References 34 publications

Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers

Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers

Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn

Regenerative Potential of Human Breast Milk: A Natural Reservoir of Nutrients, Bioactive Components and Stem cells

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