Macrophage migration inhibitory factor in patients with vitiligo and relationship between duration and clinical type of disease

Serarslan, Gamze; Yönden, Zafer; Söğüt, Sadık; Savaş, Nazan; Çelik, Ebru; Arpacı, Abdullah

doi:10.1111/j.1365-2230.2009.03617.x

Cited by 22 publications

(28 citation statements)

References 8 publications

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“…In the present study, we demonstrated that serum MIF concentrations were significantly elevated in most patients with vitiligo vulgaris, in agreement with the study from Serarslan et al (12). Additionally, we measured the MIF mRNA levels in PBMCs and skin tissues for the first time and compared the relationship between MIF expressions and the disease severity and activity in vitiligo vulgaris.…”

Section: Discussionsupporting

confidence: 94%

“…On the other hand, we observed that both MIF mRNA levels in PBMCs and serum MIF concentrations were positively associated with the VASI scores in vitiligo vulgaris, whereas Serarslan et al (12) reported that there was no relationship between body surface area (BSA) and serum MIF levels in vitiligo. Some differences do exist in the measurement of skin lesional areas by different evaluators and, compared with the BSA scores, the VASI scores include both skin lesional areas and the degree of depigmentation, which may be the reasons for the difference between our results and those reported by Serarslan et al…”

Section: Discussionmentioning

confidence: 55%

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Relationship of macrophage migration inhibitory factor levels in PBMCs, lesional skin and serum with disease severity and activity in vitiligo vulgaris

Xue

Guan

et al. 2013

Braz J Med Biol Res

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Melanocyte loss in vitiligo vulgaris is believed to be an autoimmune process. Macrophage migration inhibitory factor (MIF) is involved in many autoimmune skin diseases. We determined the possible role of MIF in the pathogenesis of vitiligo vulgaris, and describe the relationship between MIF expressions and disease severity and activity. Serum MIF concentrations and mRNA levels in PBMCs were measured in 44 vitiligo vulgaris patients and 32 normal controls, using ELISA and real-time RT-PCR. Skin biopsies from 15 patients and 6 controls were analyzed by real-time RT-PCR. Values are reported as median (25th-75th percentile). Serum MIF concentrations were significantly increased in patients [35.81 (10.98-43.66) ng/mL] compared to controls [7.69 (6.01-9.03) ng/mL]. MIF mRNA levels were significantly higher in PBMCs from patients [7.17 (3.59-8.87)] than controls [1.67 (1.23-2.42)]. There was also a significant difference in MIF mRNA levels in PBMCs between progressive and stable patients [7.86 (5.85-9.13) vs 4.33 (2.23-8.39)] and in serum MIF concentrations [40.47 (27.71-46.79) vs 26.80 (10.55-36.07) ng/mL]. In addition, the vitiligo area severity index scores of patients correlated positively with changes of both serum MIF concentrations (r = 0.488) and MIF mRNA levels in PBMCs (r = 0.426). MIF mRNA levels were significantly higher in lesional than in normal skin [2.43 (2.13-7.59) vs 1.18 (0.94-1.83)] and in patients in the progressive stage than in the stable stage [7.52 (2.43-8.84) vs 2.13 (1.98-2.64)]. These correlations suggest that MIF participates in the pathogenesis of vitiligo vulgaris and may be useful as an index of disease severity and activity.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 55%

Relationship of macrophage migration inhibitory factor levels in PBMCs, lesional skin and serum with disease severity and activity in vitiligo vulgaris

Xue

Guan

et al. 2013

Braz J Med Biol Res

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“…Among these patients, vitiligo vulgaris was the most common type, which was in accordance with the investigation by Liu et al . Over 50% of patients reported that the BSA of vitiligo patches was less than 10%, which was similar to the result of Serarslan et al …”

Section: Discussionsupporting

confidence: 90%

Comprehensive survey of vitiligo patients in the northeast of China using a predesigned questionnaire

Lin

Tian

Bai

et al. 2017

The Journal of Dermatology

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To assess the sociodemographic data and clinical information of outpatients affected by vitiligo in the northeast of China, vitiligo patients or guardians who presented to the clinic were invited to participate in an exploratory questionnaire. The questionnaire consisted of two sections related to vitiligo, including sociodemographic data and clinical information. A total of 983 vitiligo patients answered the questionnaire. The rates of female and male patients were comparable. The investigated patients were mostly young and middle-aged. Most patients suffered from vitiligo in childhood or young adulthood. Vitiligo vulgaris was the most common type of vitiligo in clinic and 53.0% of patients were categorized as body surface area (BSA) of 10% or less. In response to the latest treatment, 43.6% of patients achieved good response (completely stopped or almost disappeared). More patients at active stage showed good response than the patients at stable stage (v 2 = 7.866, P < 0.05). Chronic comorbid condition(s) were observed in 12.6% of patients with BSA of more than 10%, whereas those were seen in 6.0% of patients with BSA of 10% or less (v 2 = 12.969, P < 0.05). In conclusion, active vitiligo seems to respond better than stable vitiligo and complications with other autoimmune diseases more frequently observed in severe patients than mild patients. The current study presented a comprehensive understanding of vitiligo in the northeast of China.

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“…They demonstrated that mean serum MIF level is higher than that of controls, indicating the involvement of MIF in the pathogenesis of vitiligo. [30]…”

Section: Resultsmentioning

confidence: 99%

Macrophage migration inhibitory factor as an incriminating agent in dermatological disorders

2013

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Macrophage migration inhibitory factor (MIF) is a critical immunoregulatory pluripotent cytokine. It has been re-evaluated as a proinflammatory cytokine, pituitary hormone and glucocorticoid-induced immunoregulatory protein. MIF exists in human epidermis, especially in the basal layer and also is expressed constitutively by monocytes/macrophages, T cells, B cells, endocrine, and epithelial cells. In the field of dermatology, MIF is believed to be a detrimental factor in inflammatory dermatological diseases including atopic dermatitis (AD), psoriasis, vitiligo, pemphigus vulgaris, bullous pemphigoid (BP), alopecia areata (AA) as well as other conditions such as photoaging, and photocarcinigenesis. The objective of this review is to gather and summarize MIF related disorders in dermatology and present valuable information for readers and researchers.

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Macrophage migration inhibitory factor in patients with vitiligo and relationship between duration and clinical type of disease

Abstract: Mean serum MIF level of patients with vitiligo was higher than that of controls, indicating that MIF has a role in the pathogenesis of vitiligo.

Cited by 22 publications

References 8 publications

Relationship of macrophage migration inhibitory factor levels in PBMCs, lesional skin and serum with disease severity and activity in vitiligo vulgaris

Relationship of macrophage migration inhibitory factor levels in PBMCs, lesional skin and serum with disease severity and activity in vitiligo vulgaris

Comprehensive survey of vitiligo patients in the northeast of China using a predesigned questionnaire

Macrophage migration inhibitory factor as an incriminating agent in dermatological disorders

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