Macrophage migration inhibitory factor as an incriminating agent in dermatological disorders

Abstract

Macrophage migration inhibitory factor (MIF) is a critical immunoregulatory pluripotent cytokine. It has been re-evaluated as a proinflammatory cytokine, pituitary hormone and glucocorticoid-induced immunoregulatory protein. MIF exists in human epidermis, especially in the basal layer and also is expressed constitutively by monocytes/macrophages, T cells, B cells, endocrine, and epithelial cells. In the field of dermatology, MIF is believed to be a detrimental factor in inflammatory dermatological diseases including atopic dermatitis (AD), psoriasis, vitiligo, pemphigus vulgaris, bullous pemphigoid (BP), alopecia areata (AA) as well as other conditions such as photoaging, and photocarcinigenesis. The objective of this review is to gather and summarize MIF related disorders in dermatology and present valuable information for readers and researchers.

Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico

“…MIF has been named as “an incriminating agent in dermatological disorders” (Pazyar, Feily, & Yaghoobi, 2013). However, few studies analyze its role in the pathophysiology of dermatological diseases.…”

MIF Antagonist (CPSI-1306) Protects against UVB-Induced Squamous Cell Carcinoma

“…MIF has recently been recognized to be an important player in a multitude of skin diseases of infectious, inflammatory, and neoplastic etiologies, including SCC (14, 15). UVB light functions as a complete carcinogen in skin by initiating genetic mutations through direct DNA damage and production of ROS as well as promoting the survival and growth of the transformed cells to produce tumors (16).…”

Expression Patterns of Macrophage Migration Inhibitory Factor and Its Gene Variants (MIF-173 G˃C) in Verruca Vulgaris

“… 24 , 25 MIF has been named as “an incriminating agent in dermatological disorders”. 26 Limited research, however, has looked into its function in the pathophysiology of dermatological disorders. 27 MIF has been thought to play a key function as a proinflammatory cytokine since its discovery; however, MIF is now thought to modulate the inflammatory “set point” by controlling the release of other pro-inflammatory mediators.…”