Macrophage migration inhibitory factor –173<scp>G</scp>/<scp>C</scp> gene polymorphism increases the risk of renal disease: A meta‐analysis

Xiang, Tong; He, Jie; Liu, Sitong; Peng, Shoujiao; Yan, Zhipeng; Zhang, Yonggang; Fan, Hong

doi:10.1111/nep.12353

Cited by 16 publications

(11 citation statements)

References 43 publications

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“…Higher frequency in patients with nephrotic syndrome IL interleukin; FKBP5 FK506 binding protein; MIF macrophage migration inhibitory factor; NR3C1 nuclear receptor subfamily 3 group C, member 1; TNF-α tumor necrosis factor alpha [106]. The hypothesis is that the G/C substitution at 173 bp of the MIF gene increases the MIF level in serum and could therefore cause a pro-inflammatory response, induce injury to podocytes, and accelerate the progression of glomerulosclerosis [107].…”

Section: Il-4 Promotermentioning

confidence: 99%

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

Schijvens

Heine²,

Wildt

et al. 2018

Pediatr Nephrol

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Nephrotic syndrome is one of the most common glomerular disorders in childhood. Glucocorticoids have been the cornerstone of the treatment of childhood nephrotic syndrome for several decades, as the majority of children achieves complete remission after prednisone or prednisolone treatment. Currently, treatment guidelines for the first manifestation and relapse of nephrotic syndrome are mostly standardized, while large inter-individual variation is present in the clinical course of disease and side effects of glucocorticoid treatment. This review describes the mechanisms of glucocorticoid action and clinical pharmacokinetics and pharmacodynamics of prednisone and prednisolone in nephrotic syndrome patients. However, these mechanisms do not account for the large inter-individual variability in the response to glucocorticoid treatment. Previous research has shown that genetic factors can have a major influence on the pharmacokinetic and dynamic profile of the individual patient. Therefore, pharmacogenetics may have a promising role in personalized medicine for patients with nephrotic syndrome. Currently, little is known about the impact of genetic polymorphisms on glucocorticoid response and steroid-related toxicities in children with nephrotic syndrome. Although the evidence is limited, the data summarized in this study do suggest a role for pharmacogenetics to improve individualization of glucocorticoid therapy. Therefore, studies in larger cohorts with nephrotic syndrome patients are necessary to draw final conclusions about the influence of genetic polymorphisms on the glucocorticoid response and steroid-related toxicities to ultimately implement pharmacogenetics in clinical practice.

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Section: Il-4 Promotermentioning

confidence: 99%

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

Schijvens

Heine²,

Wildt

et al. 2018

Pediatr Nephrol

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“…Additionally, MIF had been shown to play a crucial role in the trafficking and regulation of innate and adaptive immunity 9, 29, 30 . In previous studies, we found that the MIF gene variant may be associated with susceptibility to cancer and renal disease for which cytokines and immuno-regulation play an important role in pathogenesis 17, 31 .…”

Section: Discussionmentioning

confidence: 92%

Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis

Xiang

Yan

Qin

et al. 2017

Sci Rep

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Many studies have indicated that Macrophage migration inhibitory factor (MIF)-173G/C gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB). Additionally, some studies have suggested that there are higher levels of serum MIF in patients with PTB than the controls. However, the results of these studies were underpowered. The current study aimed to precisely evaluate the association between the MIF-173G/C polymorphism and serum MIF concentrations with PTB. Therefore, a systematic literature search was preformed to identify studies involving the indicated association. Eleven articles (1316 cases and 1272 controls) were included in the study. The results indicated that the MIF-173G/C polymorphism was significantly associated with PTB susceptibility, especially in Asians. Interestingly, the results further detected that circulating MIF levels were significantly higher in patients with PTB than in healthy controls, but this was only the case among Asians. Moreover, the statistical significance was also similar to that of the high quality group. The present study indicated that the MIF-173G/C polymorphism may contribute to the development of PTB. Furthermore, significantly higher serum MIF levels were observed in PTB patients than in controls, which further indicated that the MIF may play an important role in PTB progression, particularly in Asians.

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“…Moreover, the findings of a meta-analysis designated that this variant may be related to glucocorticoid resistance in child patients with idiopathic nephrotic syndrome (Tong et al, 2015[29]). A meta-analysis performed by (Kaalla et al, 2013[13]) showed that MIF -173 G > C variant was not associated with juvenile idiopathic arthritis.…”

Section: Discussionmentioning

confidence: 99%

Macrophage migration inhibitory factor -173 G > C polymorphism and risk of tuberculosis: a meta-analysis

Naderi

Hashemi

Ansari

2017

EXCLI Journal; 16:Doc313; ISSN 1611-2156

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Macrophage migration inhibitory factor –173G/C gene polymorphism increases the risk of renal disease: A meta‐analysis

Abstract: This study suggested that MIF -173G/C gene polymorphism may increase risk of renal disease, especially in children. Furthermore, the meta-analysis also indicated that this gene polymorphism may increase risk of glucocorticoid resistance in child patients with INS.

Cited by 16 publications

References 43 publications

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis

Macrophage migration inhibitory factor -173 G > C polymorphism and risk of tuberculosis: a meta-analysis

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