Macrophage membrane-coated iron oxide nanoparticles for enhanced photothermal tumor therapy

Abstract

Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should have long blood circulation times and active cancer targeting. Additionally, they should be harmless and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (FeO NPs). Inherited from the FeO core and the macrophage membrane shell, the resulting FeO@MM NPs exhibited good biocompatibility, immune evasion, cancer targeting and light-to-heat conversion capabilities. Due to the favorable in vitro and in vivo properties, biomimetic FeO@MM NPs were further used for highly effective photothermal therapy of breast cancer in nude mice. Surface modification of synthetic nanomaterials with biomimetic cell membranes exemplifies a novel strategy for designing an ideal nanoplatform for translational medicine.

Cell Membrane-Camouflaged Nanocarriers for Cancer Diagnostic and Therapeutic

“…CM-coated NPs were recently employed to further improve PTT agent delivery and enhance the therapeutic efficacy of PTT. Meng et al developed a macrophage membrane-coated magnetic iron oxide NP (Fe 3 O 4 @MM NP) that exhibited excellent biocompatibility, prolonged circulation time, tumortargeting ability, and effective PTT for breast cancer in vivo (Meng et al, 2018). RBC-cancer cell hybrid membranes can also be employed to camouflage melanin NPs, producing Melanin@ RBC-M in order to improve therapeutic PTT efficacy.…”

Interactions Between Tumor Biology and Targeted Nanoplatforms for Imaging Applications

“…Macrophages are capable of tumor homing and can avoid reticuloendothelial system (RES) uptake, therefore cell membrane vesicles derived from macrophages (MM‐vesicles) were coated onto Fe 3 O 4 NPs for photothermal therapy (PTT). Fe 3 O 4 @MM NPs showed good biocompatibility, immune system evasion, and breast cancer targeting arising from the source macrophages 299…”

Preparation and Application of Iron Oxide Nanoclusters

“…Recently, cell membrane-coated iron oxide nanoparticles have been created for tumor targeting and drug delivery [57][58][59][60]. For example, macrophage membrane-coated iron oxide nanoparticles have been shown to be effective nanocarriers for tumor targeting and therapy [58]. In that study, the functional transmembrane receptors were able to recognize cancer cells via cell-cell adhesion between macrophage and cancer cell surfaces for effective cell targeting.…”

“…Figure 9c shows MRI images of a control mouse and a mouse 48 h post-injection, where the bright region near the heart suggested the long blood circulation time of these nanoparticle-loaded capsules. Recently, cell membrane-coated iron oxide nanoparticles have been created for tumor targeting and drug delivery [57][58][59][60]. For example, macrophage membrane-coated iron oxide nanoparticles have been shown to be effective nanocarriers for tumor targeting and therapy [58].…”