Macrophage-mediated erosion of gamma irradiated poly(trimethylene carbonate) films

Bat, Erhan; Kooten, Theo G. van; Feijén, Jan; Grijpma, Dirk W.

doi:10.1016/j.biomaterials.2009.03.033

Cited by 55 publications

(76 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that the erosive action of macrophages on PCL surface is very small if any was already shown by Bat et al [7]. Notwithstanding, Mabileau et al [33] cultivated macrophages on poly(-hydroxyethyl methacrylate) surfaces and found that the erosive effect of the cells is highly depended on the cross-linking density of the material.…”

Section: Resultsmentioning

confidence: 83%

“…Both polycaprolactone (PCL) and poly(L-lactide) (PLLA) are hydrophobous semicrystalline polymers. The ester groups of the main chain are susceptible to hydrolysis and thus PCL and PLLA degrades in the presence of water, phosphate-buffered saline (PBS) or lipoprotein lipase [6,7]. Other hydrolytic enzymes do not show significant effect on the degradation rate of these polymers [7e9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

Fernández

Oberti

Vikingsson

et al. 2016

Polymer Degradation and Stability

View full text Add to dashboard Cite

a b s t r a c tThe aim of this study is to show that introducing a small fraction of hydrophilic groups into a hydrophobic polyester favor the macrophage activity by accelerating the degradation action in aqueous media. It is also seen that differentiation of MSCs cultured in monolayer towards bone in specific differentiation media is favored in these materials with respect to the corresponding pristine polyesters. Polymer networks based in polycarpolactone or poly(L-lactide) and containing a small fraction of poly(-hydroxyethyl acrylate) have been synthesized. Degradation kinetics in vitro was monitored by mass loss and swelling capacity of the polymer network in good solvents, the later as representative of chain cleavage. Hydrolytic and enzymatic degradation is accelerated by the inclusion of poly(hydroxyethyl acrylate) blocks in the network. Macrophages were cultured on the surface of the network films, showing its capacity to erode the material surface but also to accelerate bulk degradation. Bone marrow mesenchymal stem cells were cultured in monolayer on the membranes in osteogenic media, showing an increase of specific markers expression in comparison to pristine polyesters.

show abstract

Section: Resultsmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

Fernández

Oberti

Vikingsson

et al. 2016

Polymer Degradation and Stability

View full text Add to dashboard Cite

show abstract

“…However, a burst release phenomenon of VCM was observed. Poly(trimethylene carbonate) (PTMC), 18,19 a surface-eroding biodegradable material that is fully biocompatible, 20 exhibits an ideal sustained, zero-order release profile and promotes bone regeneration 21 due to its unique degradation behavior. 22 In this study, with the aim to increase the sustained effectiveness of intracellular antibiotics and the probability of biocompatibility, VCM/TMC NP-PTMC was prepared using a composite of VCM/TMC NPs and PTMC.…”

mentioning

confidence: 99%

“…Meanwhile, the PTMC is best known as a surface-eroding polymer and is fully biocompatible, which appears to fully degrade in bone and assists in promoting bone regeneration. 18,21 Generally, in the clinic, patients are commonly supplied therapy for at least 4 weeks. Therefore, VCM/TMC NP-PTMC could meet the requirements.…”

mentioning

confidence: 99%

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

Zhang¹,

Liang²,

Xu³

et al. 2017

IJN

View full text Add to dashboard Cite

Surgery and the local placement of an antibiotic are the predominant therapies to treat chronic osteomyelitis. Vancomycin-loaded N -trimethyl chitosan nanoparticles (VCM/TMC NPs) as a potential drug delivery system have high intracellular penetration and effective intracellular antibacterial activity. This study investigated the effects of a biocompatible material, poly(trimethylene carbonate) (PTMC), to increase the sustained effectiveness of an intracellular antibiotic and its potential application in antibiotic delivery. VCM/TMC NP-PTMC was characterized using scanning electron microscopy and Fourier transform infrared spectroscopy to determine the morphology, stability and chemical interaction of the drug with the polymer. Further, the biodegradation, antibacterial activity, protein adsorption, cell proliferation and drug release characteristics were evaluated. In addition, a Staphylococcus aureus -induced osteomyelitis rabbit model was used to investigate the antibiotic activity and bone repair capability of VCM/TMC NP-PTMC. The results showed that the composite beads of VCM/TMC NPs followed a sustained and slow release pattern and had excellent antibacterial activity and a higher protein adsorption and cell proliferation rate than the VCM-PTMC in vitro. Furthermore, VCM/TMC NP-PTMC inhibits bacteria and promotes bone repair in vivo. Thus, VCM/TMC NP-PTMC might be beneficial in periodontal management to reduce the bacterial load at the infection site and promote bone repair.

show abstract

“…The erosion rate of these films was 159±8 (µg/(cm 2 ×day)), which corresponds to a mass loss The water in air contact angles and the water uptake of non-crosslinked and of photocrosslinked PTMC films are given in Previously, hydrolytic enzymes and oxidative species that can be secreted by macrophages have been shown to erode PTMC networks 21, 43 . We investigated the erosion of our photocrosslinked PTMC networks using aqueous cholesterol esterase (CE) and aqueous KO 2 solutions.…”

Section: Human Mesenchymal Stem Cell Culturingmentioning

confidence: 99%

Elastomeric networks based on trimethylene carbonate polymers for biomedical applications : physical properties and degradation behaviour

Bat¹

Self Cite

View full text Add to dashboard Cite

Macrophage-mediated erosion of gamma irradiated poly(trimethylene carbonate) films

Cited by 55 publications

References 34 publications

Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

Biodegradable polyester networks including hydrophilic groups favor BMSCs differentiation and can be eroded by macrophage action

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

Elastomeric networks based on trimethylene carbonate polymers for biomedical applications : physical properties and degradation behaviour

Contact Info

Product

Resources

About