Macrophage-lymphocyte cluster formation in the medullary sinus of lymph node after immunization with sheep red blood cells (SRBC)

Ae, Friess

doi:10.1007/bf00220171

Cited by 10 publications

(1 citation statement)

References 21 publications

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“…However, intercellular bridges have been described between cytotoxic lymphocytes and target cells31 and in macrophage-lymphocyte cluster formation in rat lymph nodes after immunization with sheep red blood cells. 32 The similarity of the type I contact with septate junction, which has been considered a fixation junction, and the obvious requirement of some mechanism of binding fixation between antigenpresenting cells and lymphocytes leads us to suggest that the type 1 contact might represent a mechanism of transient fixation between LC and lymphocytes.…”

Section: Type I Contactmentioning

confidence: 99%

Ultrastructural characteristics of the contact zones between langerhans cells and lymphocytes

Concha

Figueroa

Caorsi

1988

The Journal of Pathology

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The present work was carried out to look for the ultrastructural substrate of the contact zones between Langerhans cells and lymphocytes. A high resolution electron microscopic analysis of the contact zones between Langerhans cells and lymphocytes was performed. The material used for this study was obtained from experimental contact dermatitis in mice, and human cervical squamous carcinoma and mycosis fungoides. Three types of cell-cell binding were found. Type I is a junction-like structure characterized by the presence of intercellular bridges. It is suggested that this contact might represent a fixation mechanism between the two cells. Type II is characterized by a glycocalyx-glycocalyx continuity. An immunological function--recognition and antigen presentation--is proposed for this type of contact. Type III is a septilaminar tight contact area which seems to be a gap junction. It is suggested that all these types of physical contact might be the morphological expression of interaction between antigen presenting cells and lymphocytes.

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Section: Type I Contactmentioning

confidence: 99%

Ultrastructural characteristics of the contact zones between langerhans cells and lymphocytes

Concha

Figueroa

Caorsi

1988

The Journal of Pathology

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The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage

1980

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The internal structure of cells lining the lymphatic sinus of the lymph node includes the presence of large bristle-coated vesicles, transfer tubules, and vesicular organelles for the uptake and intracellular disposition of endocytosed material. The lining cells of the sinuses phagocytose particulate material from the lymph in the same manner as the sinusoidal endothelium of the bone marrow takes up particulates from the blood and, thus, are similar in this respect to the endothelial lining of the bone marrow sinusoids. Transmission and scanning electron microscopic examination of the lymphatic sinus wall in rat lymph nodes show that the walls of the lymphatic sinuses are continuous and do not have permanent apertures allowing free communication between the extrasinusoidal and intrasinusoidal compartments in the lymph node. Migrating lymphocytes cross the lymphatic sinus wall intracellularly, i.e., through the body of the lining cell, by making a temporary migration pore, which closes after the cell has reached the lumen of the sinus. In addition there are sporadic aggregations of macrophages in transmural positions. The direction of their movement is unknown.

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Overall architecture and pattern of lymph flow in the rat lymph node

1982

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The immunogenic content of the afferent lymph stimulates structures in the lymph node. Thus, a better knowledge of the processes of lymph flow and filtration in the organ should help us better understand various aspects of the node's function. To gain this understanding, we analyzed the distribution of flow in rat node draining areas locally injected with a small dose of China ink. Because the lymph-flow pattern is likely related to the overall architecture of the node, we simultaneously studied its morphology. Indeed, while the different structures of the node are known, some aspects of its overall architecture need to be resolved. The present work aimed to accomplish this by an analysis of semiserial sections of nodes from various anatomical locations in normal rats; the sections were stained by the Dominici technique or silver-impregnated.With respect to their architecture, the nodes could be distinguished into those with either a discontinuous or a continuous subcapsular sinus and peripheral cortex. These are referred to here, respectively, as segmented and nonsegmented nodes. In the segmented nodes, the subcapsular sinus with the peripheral cortex is separated by "gaps," in which medullary sinuses reached the capsule. Further, a node appears to be divided into one or more "physiological compartments," each one representing a nodal area related to an opening of an afferent lymphatic.The findings on China-ink distribution indicate that the lymph-flow pattern varies in different nodes and is determined by the particular architecture of a node, i.e., the lymph flow in a given node aligns itself along the pattern of segmentation of the organ. The findings suggest that the lymph content is first held by the endothelium lining the inner wall of a restricted area of the subcapsular sinus in a concentration which decreases with the distance from the related afferent lymphatic opening. Part of the content, possibly its nonimmunogenic fraction, would later be released to flow further along the sinus. It would then be phagocytosed by the macrophage accumulation located in the portions of medullary sinuses into which the lymph enters from the subcapsular sinus. The lymph thus filtered then flows along the medullary sinuses and leaves the organ. The latter findings also indicate that a node is divided into physiological compartments, each one being stimulated by the lymph from a given afferent lymphatic opening. As the immunogenic content of the lymph can differ from one lymphatic to another, this explains the frequent variations in similar structures located in different areas of a given node. Hence, the pattern of distribution of the openings of the afferent lymphatics of a node can account for the particularities of its overall architecture and its division into physiological compartments.

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Macrophage-lymphocyte cluster formation in the medullary sinus of lymph node after immunization with sheep red blood cells (SRBC)

Cited by 10 publications

References 21 publications

Ultrastructural characteristics of the contact zones between langerhans cells and lymphocytes

Ultrastructural characteristics of the contact zones between langerhans cells and lymphocytes

The structure of the sinus wall of the lymph node relative to its endocytic properties and transmural cell passage

Overall architecture and pattern of lymph flow in the rat lymph node

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