Macrophage colony-stimulating factor enhances monocyte and macrophage antibody-dependent cell-mediated cytotoxicity

Mufson, R. A.; Aghajanian, J. D.; Wong, Gordon G.; Woodhouse, Clive S.; Morgan, Alton C.

doi:10.1016/0008-8749(89)90234-7

Cited by 62 publications

(16 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nakoinz [19] found that human M-CSF alone had little effect but could enhance ADCC to murine tumor targets when used as a costimulant with interferons alpha, beta, gamma, and IL-2. Mufson et al [20] found that M-CSF- Cheung and Munn 1221 found that antitumor cytotoxicity mediated by human blood monocytes was enhanced by M-CSF. Target cells were found to be phagocytosed with their radioisotope markers intact by cultured monocytes.…”

Section: Discussionmentioning

confidence: 97%

Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage‐mediated antibody dependent cellular cytotoxicity

Liesveld

Frediani

Winslow

et al. 1991

J of Cellular Biochemistry

View full text Add to dashboard Cite

Mononuclear phagocytes participate in host immunological defense against tumors. We have investigated the role of selected recombinant cytokines on human macrophage-mediated tumor cytotoxicity in vitro utilizing a human colon cancer cell line target, SW1116, and murine monoclonal antibody 17-1A. Blood monocytes were kept in continuous culture to allow differentiation into macrophages. Maximum antibody dependent cellular cytotoxicity (ADCC) as measured in a 3H-thymidine release assay occurred after culturing the monocytes for 5-7 days. Human recombinant macrophage colony stimulating factor (CSF) (1,000 U/ml) did not increase ADCC above control levels whereas recombinant human granulocyte-macrophage colony stimulating factor, interleukin 4, and interleukin 3 were all capable of increasing ADCC. Antibodies to the CD11/CD18 integrin receptors did not significantly inhibit ADCC. When the ADCC incubation occurred in the presence of antibodies to the human Fc receptors, ADCC was inhibited significantly only by anti-FcRIII (3G8). A role for tumor necrosis factor alpha or other soluble mediators of cytotoxicity was not demonstrable in this system. These studies suggest avenues for manipulation and augmentation of macrophage-mediated antitumor ADCC.

show abstract

Section: Discussionmentioning

confidence: 97%

Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage‐mediated antibody dependent cellular cytotoxicity

Liesveld

Frediani

Winslow

et al. 1991

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

“…After 24 h, the wells were washed with PBS to remove nonadherent cells, and 100 l of fresh DMEM without fetal calf serum was added to each well. This procedure consistently yields monocyte purities of Ͼ80% as assessed by flow cytometry (19,20).…”

Section: Methodsmentioning

confidence: 99%

Thromboxane Receptor Signaling Is Required for Fibronectin-induced Matrix Metalloproteinase 9 Production by Human and Murine Macrophages and Is Attenuated by the Arhgef1 Molecule

Hartney

Gustafson

Bowler

et al. 2011

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…Although phagocytes are considered important in resistance to and eradication of fungi, the expression of these functions in vitro requires activation of the effector cells. Together with other investigators [22][23][24][25][26][27], we have previously reported that M-CSF has the capacity to enhance antifungal activity of human monocytes [18]. This study was designed to address whether M-CSF has a similar upregulatory effect on phagocytic abilities of neonatal monocytes against C. albicans.…”

Section: Discussionmentioning

confidence: 99%

“…M-CSF acts on monocytic progenitors accelerating their differentiation, as well as on mature monocytes modulating specific functions [22,23]. For example, M-CSF enhances the oxidative burst activity in response to soluble stimuli, upregulates Fc receptor expression, enhances macrophage migration and augments fungicidal activity against blastoconidia of C. albicans [24][25][26][27].…”

mentioning

confidence: 99%

Effects of Macrophage Colony-Stimulating Factor on Antifungal Activity of Neonatal Monocytes against<i> Candida albicans</i>

et al. 2001

View full text Add to dashboard Cite

The effects of recombinant macrophage-colony stimulating factor (M-CSF) on antifungal activities of monocytes (MNC) from healthy neonates and adults against Candida albicans were compared. Pretreatment of adult and neonatal MNC with 15 ng/ml of M-CSF for 4 days significantly increased superoxide anion (O₂^–) production in response to phorbol myristate acetate. While M-CSF-treated MNC from adults produced significantly higher O₂^– in response to Candida blastoconidia, M-CSF-treated neonatal MNC did not show a similar response. Further, M-CSF significantly enhanced phagocytosis of C. albicans by adult MNC but not by neonatal MNC. While M-CSF enhances antifungal activities of adult MNC against C. albicans, it does not appear to affect anticandidal function of neonatal MNC.

show abstract

Macrophage colony-stimulating factor enhances monocyte and macrophage antibody-dependent cell-mediated cytotoxicity

Cited by 62 publications

References 15 publications

Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage‐mediated antibody dependent cellular cytotoxicity

Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage‐mediated antibody dependent cellular cytotoxicity

Thromboxane Receptor Signaling Is Required for Fibronectin-induced Matrix Metalloproteinase 9 Production by Human and Murine Macrophages and Is Attenuated by the Arhgef1 Molecule

Effects of Macrophage Colony-Stimulating Factor on Antifungal Activity of Neonatal Monocytes against<i> Candida albicans</i>

Contact Info

Product

Resources

About