1991
DOI: 10.1002/jcb.240450412
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Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage‐mediated antibody dependent cellular cytotoxicity

Abstract: Mononuclear phagocytes participate in host immunological defense against tumors. We have investigated the role of selected recombinant cytokines on human macrophage-mediated tumor cytotoxicity in vitro utilizing a human colon cancer cell line target, SW1116, and murine monoclonal antibody 17-1A. Blood monocytes were kept in continuous culture to allow differentiation into macrophages. Maximum antibody dependent cellular cytotoxicity (ADCC) as measured in a 3H-thymidine release assay occurred after culturing th… Show more

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Cited by 29 publications
(10 citation statements)
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“…In contrast to other studies in this field (Capone et al, 1984;Hagan et al, 1986; (Velders et al, 1995 (Velders et al, 1996). In agreement with Herlyn et al (1985), our results, as presented in Figure 2, (Velders et al, 1996) The requirement of accessory adhesions between effector and target for ADCC is not very clear, however the scope of the publications on the subject suggests their importance (Liesveld et al, 1991;Webb et al, 1991;Edwards et al, 1992; Kushner and Cheung, 1992 [owing to their chimerization using the same genes for the constant Ig chains (Sun et al, 1987;Velders et al, 1994)], it is the affinity of the antibody to the target antigen or the three-dimensional orientation of Fc tails that is of importance. From the results presented in Figure 4 we conclude that high MAb affinity, or a large number of antibody-antigen interconnections between effector and target cells, may well compensate the reducing effect on ADCC of the suppressed accessory interactions.…”
Section: Adcc Kinetics and Mab Affinitysupporting
confidence: 92%
“…In contrast to other studies in this field (Capone et al, 1984;Hagan et al, 1986; (Velders et al, 1995 (Velders et al, 1996). In agreement with Herlyn et al (1985), our results, as presented in Figure 2, (Velders et al, 1996) The requirement of accessory adhesions between effector and target for ADCC is not very clear, however the scope of the publications on the subject suggests their importance (Liesveld et al, 1991;Webb et al, 1991;Edwards et al, 1992; Kushner and Cheung, 1992 [owing to their chimerization using the same genes for the constant Ig chains (Sun et al, 1987;Velders et al, 1994)], it is the affinity of the antibody to the target antigen or the three-dimensional orientation of Fc tails that is of importance. From the results presented in Figure 4 we conclude that high MAb affinity, or a large number of antibody-antigen interconnections between effector and target cells, may well compensate the reducing effect on ADCC of the suppressed accessory interactions.…”
Section: Adcc Kinetics and Mab Affinitysupporting
confidence: 92%
“…Phagocytosis was studied after differentiation of MDM in medium supplemented with human recombinant cytokines that have been shown to modulate macrophage function (24,29,30). We observed significant Fc␥RI-mediated phagocytosis (H22 ϫ 520C9) under all conditions (Fig.…”
Section: Resultsmentioning
confidence: 76%
“…These biological activities include the ability to stimulate the proliferation and differentiation of multipotential bone marrow progenitor cells into mature granulocytes and macrophages (Fleischmann et al, 1986). There is evidence that CSFs stimulate the phagocytic and cytocidal activity of macrophages (Handman and Burgess, 1979;Ho et al, 1990) and promote monocyte and neutrophil antibody-dependent cellular cytotoxicity (Kushner and Cheung, 1989;Liesveld et al, 1991). They may also play a major role in the maturation of dendritic cells into potent activators of resting T cells (Morrissey et al, 1987).…”
mentioning
confidence: 99%