Macrophage colony stimulating factor (CSF-1) is a central growth factor of goldfish macrophages

“…CSF-1R signaling also regulates the development and migration of fish (Hanington, Hitchen, Beamish, & Belosevic, 2009; Herbomel, Thisse, & Thisse, 2001; Wang et al, 2013), amphibian (Grayfer & Robert, 2013), and avian (Garceau et al, 2010) MΦ and CSF-1R-related receptors regulate plasmatocytes, the functional equivalent of MΦ in insects (reviewed in Ratheesh, Belyaeva, & Siekhaus, 2015). However, the finding that CSF-1R-expressing YS-derived-tissue MΦ were not retained in the hatched birds, while a CSF-1R + MΦ-restricted bone marrow progenitor could efficiently generate adult tissue MΦ (Garceau et al, 2015), suggests that the ontogeny of tissue MΦ may differ among vertebrates.…”

Section: The Csf-1r In Mononuclear Phagocyte Developmentmentioning

confidence: 99%

Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor

Chiţu

Stanley

2017

Current Topics in Developmental Biology

116

118

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Macrophages are found in all tissues and regulate tissue morphogenesis during development through trophic and scavenger functions. The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) is the major regulator of tissue macrophage development and maintenance. In combination with receptor activator of nuclear factor κB (RANK), the CSF-1R also regulates the differentiation of the bone-resorbing osteoclast and controls bone remodeling during embryonic and early postnatal development. CSF-1R-regulated macrophages play trophic and remodeling roles in development. Outside the mononuclear phagocytic system, the CSF-1R directly regulates neuronal survival and differentiation, the development of intestinal Paneth cells and of preimplantation embryos, as well as trophoblast innate immune function. Consistent with the pleiotropic roles of the receptor during development, CSF-1R deficiency in most mouse strains causes embryonic or perinatal death and the surviving mice exhibit multiple developmental and functional deficits. The CSF-1R is activated by two dimeric glycoprotein ligands, CSF-1, and interleukin-34 (IL-34). Homozygous Csf1-null mutations phenocopy most of the deficits of Csf1r-null mice. In contrast, Il34-null mice have no gross phenotype, except for decreased numbers of Langerhans cells and microglia, indicating that CSF-1 plays the major developmental role. Homozygous inactivating mutations of the Csf1r or its ligands have not been reported in man. However, heterozygous inactivating mutations in the Csf1r lead to a dominantly inherited adult-onset progressive dementia, highlighting the importance of CSF-1R signaling in the brain.

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“…Ligand-receptor binding studies demonstrated that homodimeric CSF-1 could bind to soluble CSF-1R (see teleost CSF-1R section below, Figure 1). Functional characterization of a recombinant goldfish CSF-1 was shown to induce monocyte proliferation and differentiation (Figure 1), which was abrogated in the presence of sCSF-1R or in monocytes transfected with csf-1r RNAi oligos [246,247]. Recombinant goldfish CSF-1 also aided in the long-term survival of mature macrophages in vitro [247].…”

Section: Teleost Colony Stimulating Factor-1mentioning

confidence: 99%

“…Functional characterization of a recombinant goldfish CSF-1 was shown to induce monocyte proliferation and differentiation (Figure 1), which was abrogated in the presence of sCSF-1R or in monocytes transfected with csf-1r RNAi oligos [246,247]. Recombinant goldfish CSF-1 also aided in the long-term survival of mature macrophages in vitro [247]. The recombinant CSF-1 protein was chemoattractive to PKMs, and promoted their ability to perform phagocytosis and produce antimicrobial compounds [248], suggesting a pro-inflammatory role for CSF-1 in goldfish.…”

Section: Teleost Colony Stimulating Factor-1mentioning

confidence: 99%

Regulation of Teleost Macrophage and Neutrophil Cell Development by Growth Factors and Transcription Factors

Katzenback¹,

Katakura²,

Belosevic³

2012

New Advances and Contributions to Fish Biology

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Additional information is available at the end of the chapter http://dx.doi.org/10.5772/53589 . IntroductionMacrophages and neutrophils are the sentinel cells of the innate immune response of vertebrates, such as bony fish teleosts . "s phagocytic myeloid cells, they are involved in homeostatic mechanisms, wound healing, and the detection, elimination and clearance of foreign entities including tumors, virus-infected cells and invading pathogens. Furthermore, macrophages and neutrophils are responsible for producing hundreds of bioactive molecules that are important in pathogen recognition and destruction, cellular communication and activation, initiation of an adaptive immune response and later, resolution of an inflammatory response and tissue repair. Neutrophils and macrophages, while essential to survival, have a finite lifespan. Therefore, a manufacturing centre, the hematopoietic niche, is needed for the production of myeloid cells. The hematopoietic niche must maintain basal myeloid cell production levels during homeostasis, yet retain the flexibility to ramp-up cell production in response to physiological demands, such as pathogenic insult. The development of macrophages monopoiesis and neutrophils granulopoiesis is collectively known as myelopoiesis, and is regulated by the complex interaction of colony-stimulating factors CSFs , their receptors, and intracellular transcription factor machinery that control lineage fate decisions and terminal differentiation events.Over the past years, research using the mouse model system has culminated in the identification of the site s of myelopoiesis, the progenitor cell types that give rise to mature myeloid cells, the extracellular and intracellular cues required, and a detailed understanding of the complex intracellular and extracellular milieu of factors that drive this tightly controlled © 2013 Katzenback et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.process. From these studies we understand hematopoiesis as an exquisitely fine-tuned, highly regulated, process whereby all blood cells develop from a small number of hematopoietic stem cells HSCs . HSCs are characterized as long-term repopulating, pluripotent, quiescent cells that undergo symmetrical self-renewal to sustain the population of HSCs within the hematopoietic niche, or asymmetrical division to give rise to hematopoietic progenitor cells HPCs [ ]. HPCs can develop along the lymphoid lineage, termed lymphopoiesis, to give rise to "-cells, T-cells, natural killer NK cells and dendritic cells DCs . "lternatively, HPCs can develop along an erythroid lineage, termed erythropoiesis, to give rise to erythrocytes and megakaryocytes, or develop along a myeloid lineage to give rise to granulocytes neutrophils, basophils, eosinophils, mast cells , mononuclear phagoc...

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Macrophage colony stimulating factor (CSF-1) is a central growth factor of goldfish macrophages

Cited by 35 publications

References 30 publications

Macrophage colony-stimulating factor (CSF-1) induces pro-inflammatory gene expression and enhances antimicrobial responses of goldfish (Carassius auratus L.) macrophages

Macrophage colony-stimulating factor (CSF-1) induces pro-inflammatory gene expression and enhances antimicrobial responses of goldfish (Carassius auratus L.) macrophages

Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor

Regulation of Teleost Macrophage and Neutrophil Cell Development by Growth Factors and Transcription Factors

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