Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood

Eda, Hiroyuki; Zhang, Jian; Keith, Robert H.; Michener, Marshall L.; Beidler, David; Monahan, Joseph B.

doi:10.1016/j.cyto.2010.08.005

Cited by 72 publications

(62 citation statements)

References 44 publications

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“…Similarly further reduction in serum cathepsin k was found in good responders [3.75(3-5.5)] versus poor responders [5.25(3.18-10.12)] which reflected that impact of treatment response was variable on patients of the same group. It may be due to other contributing poor factors as RF positivity, age, gender and disease duration, as three of them were male and all were seropositive and their disease duration range (12)(13)(14)(15)(16)(17)(18)(19)(20) years which declare that pathogenesis of RA may differ from a patient to another (disease severity), as well as effect of treatment varied also from one to another patient and this explanation was previously established by many authors [52].…”

Section: Discussionmentioning

confidence: 92%

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Joint Destruction and Osteoporosis are Associated with Upregulation of IL34 and Cathepsin k Expression in Rheumatoid Arthritis. Clinical Trial with Anti TNF ÃÂ± Therapy

Atef¹,

Aziz²

2015

J Arthritis

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Section: Discussionmentioning

confidence: 92%

“…association was found between IL-34 synovial tissue expression and synovitis severity in RA [11]. Eda et al, documented that IL-34 could increase IL-6 and chemokine levels in human whole blood [12]. It also could promote osteoclastogenesis in vitro [13].…”

Section: Introductionmentioning

confidence: 99%

Joint Destruction and Osteoporosis are Associated with Upregulation of IL34 and Cathepsin k Expression in Rheumatoid Arthritis. Clinical Trial with Anti TNF ÃÂ± Therapy

Atef¹,

Aziz²

2015

J Arthritis

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“…3 -7 In addition to M-CSF, IL-34 has been shown to induce the release of chemokines such as interferon inducible protein-10, IL-8 and monocyte chemoattractant protein-1 in human whole blood, through binding to the colony stimulating factor 1 receptor. IL-34 also promotes increases in IL-1β, IL-6 and TNF-α levels 12 and stimulates monocyte viability, promoting the release of proinflammatory cytokines. 8 A further study has shown that the proinflammatory cytokines IL-1β, IL-6 and TNF-α can induce IL-34 in osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

Increased Serum Interleukin-34 in Patients with Coronary Artery Disease

Jin

Yun-xia

et al. 2012

J Int Med Res

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OBJECTIVE: This study investigated levels of interleukin (IL)-34, a proinflammatory cytokine, in patients with coronary artery disease (CAD). METHODS: Following coronary artery angiography, 91 patients with CAD (including stable and unstable angina pectoris) were divided into two groups, the CAD group (coronary artery stenosis ≥ 50%) and the control group (coronary artery stenosis < 50%). Serum levels of factors including IL-34 and high sensitivity C-reactive protein (hs-CRP) were measured. RESULTS: IL-34 and hs-CRP levels were significantly higher in the CAD group than in the control group (191.3 ± 17.9 pg/ml versus 125.4 ± 14.8 pg/ml and 3.08 ± 1.81 mg/ml versus 1.42 ± 1.01 mg/ml, respectively), with a significantly positive correlation between IL-34 and hs-CRP levels in the CAD group. Multiple regression analysis showed that IL-34 and hs-CRP levels were independent predictors of CAD (IL-34: odds ratio [OR] 2.073, 95% confidence intervals (CI) 1.419, 2.672; hs-CRP: OR 1.878, 95% CI 1.172, 2.531). CONCLUSIONS: IL-34 levels were significantly increased in patients with CAD, and positively correlated with hs-CRP levels, suggesting that IL-34 may be an independent predictor of CAD.

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“…It is likely that IL-34 plays a role in inflammation, as it increases IL-6 and chemokine levels in human whole blood 11) . Interleukin-34 is also expressed in rheumatoid arthritis (RA) synovium, where it has been shown to be associated with severity of synovitis, and is elevated in serum and synovial fluid from RA patients 8) .…”

Section: Introductionmentioning

confidence: 99%

Interleukin-34 Levels in Gingival Crevicular Fluid and Plasma in Healthy and Diseased Periodontal Tissue in Presence or Absence of Obesity: A Clinico-biochemical Study

Guruprasad

Pradeep

2018

Bull. Tokyo Dent. Coll.

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Interleukin (IL)-34 has recently been identified as an alternative ligand for colonystimulating factor-1 receptor and plays an important role in osteoclastogenesis. The aim of this study was to assess and compare IL-34 levels in gingival crevicular fluid (GCF) and plasma in obese individuals in the presence or absence of periodontal disease and to determine whether they showed a correlation with disease severity. Forty patients aged between 25 and 40 yr were enrolled and categorized into 4 groups: 10 non-obese patients with healthy periodontium (Group I); 10 obese patients with healthy periodontium (Group II); 10 non-obese patients with chronic periodontitis (Group III); and 10 obese patients with chronic periodontitis (Group IV). Demographic variables such as age and body mass index score were recorded and assessed, together with clinical periodontal parameters such as the gingival index, probing pocket depth, and clinical attachment level scores in all groups. The GCF and plasma levels of IL-34 were quantified using enzyme-linked immunosorbent assay. The results showed that the mean IL-34 concentrations in GCF or plasma were highest in Group IV, followed by Group III, Group II, and Group I, with the difference among them being statistically significant (p<0.05). These results suggest that obese individuals with periodontitis have higher GCF and plasma IL-34 levels than non-obese individuals with healthy periodontium. This suggests IL-34 as a potential inflammatory marker of periodontal disease and obesity.

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Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood

Cited by 72 publications

References 44 publications

Joint Destruction and Osteoporosis are Associated with Upregulation of IL34 and Cathepsin k Expression in Rheumatoid Arthritis. Clinical Trial with Anti TNF ÃÂ± Therapy

Joint Destruction and Osteoporosis are Associated with Upregulation of IL34 and Cathepsin k Expression in Rheumatoid Arthritis. Clinical Trial with Anti TNF ÃÂ± Therapy

Increased Serum Interleukin-34 in Patients with Coronary Artery Disease

Interleukin-34 Levels in Gingival Crevicular Fluid and Plasma in Healthy and Diseased Periodontal Tissue in Presence or Absence of Obesity: A Clinico-biochemical Study

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Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood

Cited by 72 publications

References 44 publications

Joint Destruction and Osteoporosis are Associated with Upregulation of IL34 and Cathepsin k Expression in Rheumatoid Arthritis. Clinical Trial with Anti TNF ÃÂ± Therapy

Joint Destruction and Osteoporosis are Associated with Upregulation of IL34 and Cathepsin k Expression in Rheumatoid Arthritis. Clinical Trial with Anti TNF ÃÂ± Therapy

Increased Serum Interleukin-34 in Patients with Coronary Artery Disease

Interleukin-34 Levels in Gingival Crevicular Fluid and Plasma in Healthy and Diseased Periodontal Tissue in Presence or Absence of Obesity: A Clinico-biochemical Study

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Product

Resources

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Joint Destruction and Osteoporosis are Associated with Upregulation of IL34 and Cathepsin k Expression in Rheumatoid Arthritis. Clinical Trial with Anti TNF ÃÂ± Therapy

Joint Destruction and Osteoporosis are Associated with Upregulation of IL34 and Cathepsin k Expression in Rheumatoid Arthritis. Clinical Trial with Anti TNF ÃÂ± Therapy