Macrophage activating activity of pyrrole alkaloids from Morus alba fruits

Kim, Seon Beom; Chang, Bo Yoon; Jo, Yang Hee; Lee, Sang Hoon; Han, Sang‐Bae; Hwang, Bang Yeon; Kim, Sung Yeon; Lee, Mi Kyeong

doi:10.1016/j.jep.2012.11.007

Cited by 75 publications

(47 citation statements)

References 17 publications

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“…Consumption of mulberry fruit has been linked to the prevention of various chronic diseases. Mulberry extract has been reported to have potent antioxidant activity [9], [10], antitumor activity [11], [12], hypolipidemic effect [10], [13], [14], macrophage activating effect [15], and neuroprotective activity [16], [17]. Many of these bioactivities were linked to the presence of phenolics in mulberry fruit.…”

Section: Introductionmentioning

confidence: 99%

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Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

et al. 2013

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The antidiabetic and antioxidant activities of the ethyl acetate-soluble extract (MFE) of mulberry fruit (Morus alba L.) were investigated. In vitro, MFE showed potent α-glucosidase inhibitory activity and radical-scavenging activities against DPPH and superoxide anion radicals. In vivo, MFE could significantly decrease fasting blood glucose (FBG) and glycosylated serum protein (GSP), and increase antioxidant enzymatic activities (SOD, CAT, GSH-Px) in streptozotocin (STZ)-induced diabetic mice. Bioactivity-guided fractionation of the MFE led to the isolation of 25 phenolic compounds, and their structures were identified on the basis of MS and NMR data. All the 25 compounds were isolated from mulberry fruit for the first time. Also, the α-glucosidase inhibitory activity and antioxidant activity of the phenolics were evaluated. Potent α-glucosidase inhibitory and radical-scavenging activities of these phenolics suggested that they may be partially responsible for the antidiabetic and antioxidant activities of mulberry fruit.

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Section: Introductionmentioning

confidence: 99%

“…Anthocyanins extracted from mulberry has been reported to exhibit potent neuroprotective [16] and antitumor activity [11]. Also, some alkaloids were identified from mulberry fruit and show strong bioactivities [15], [18].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

et al. 2013

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“…Anthocyaninshave been proven to be capable of scavenging the free radicals and preventing the injuries induced by free radicals (Jiang & Nie, 2014). Multiplebiological activities including the anti-oxidant (Yang, Yang, & Zheng, 2010), hypolipidemic effect (Liu et al, 2009), and macrophage-activating effect (Kim et al, 2013), are associated with the phenol content in the mulberry fruit (Donno, Cerutti, Prgomet, Mellano, & Beccaro, 2015;Ercisli & Orhan, 2007;Khan et al, 2013) and non-anthocyanin polyphenols (Dilip & Tetsuya, 2007;Farrell, Norris, Lee, Chun, & Blesso, 2015;Liang et al, 2012). As a major type of active flavonoid, rutin functions to reduce capillary fragility, improve microcirculation and can be used to treat diabetes mellitus, hypertension, hyperglycemia and other disorders (Duarte, Carvalho, Gadelha, & Braga, 2014;Fernandes et al, 2010).…”

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confidence: 99%

Partial‐least‐squares and canonical‐correlation analysis of chemical constituents and active ingredients of new types of Chinese mulberries

Sun

Chen

2018

Food Science & Nutrition

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ObjectiveTo investigate the correlation between chemical constituents and active ingredients of 13 types of Chinese mulberry fruits.MethodsThirteen types mulberry fruits were harvested. The correlation between chemical constituents and active ingredients (primarily anthocyanins and rutins) of 13 new types of Chinese mulberries was assessed using partial‐least‐squares, principle‐component and canonical‐correlation analyses.ResultsVitamin C and titratable acid in the mulberry fruits were critical components that affected the active ingredients, especially anthocyanins and rutins. The content of titratable acid content was related to the fruit flavor and maintained the balance of anthocyanins, vitamin C and rutins. Mineral elements, such as Zn and Cu, also played a vital role in these processes. Low contents of sugar, crude protein, crude fat and pectin were significantly correlated with the mineral elements.ConclusionChemical constituents and mineral elements can mutually affect the concentration. It provides a novel method for any changes in the quality of new types of Chinese mulberries, which can identify the sources of new types of natural antioxidants.

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“…Their UV spectra all displayed absorption maxima close to 293 nm, which are characteristic of the pyrrole-2-carbonyl basic skeleton [62]. The 1 H-NMR spectrum (Table 2) exhibited signals for two methine protons at δ H 6.16 (d, J = 3.9 Hz, H-4) and 7.01 (d, J = 3.9 Hz, H-3).…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

et al. 2018

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Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

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Macrophage activating activity of pyrrole alkaloids from Morus alba fruits

Cited by 75 publications

References 17 publications

Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

Partial‐least‐squares and canonical‐correlation analysis of chemical constituents and active ingredients of new types of Chinese mulberries

Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

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