Antidiabetic and Antioxidant Effects and Phytochemicals of Mulberry Fruit (Morus alba L.) Polyphenol Enhanced Extract

Abstract

The antidiabetic and antioxidant activities of the ethyl acetate-soluble extract (MFE) of mulberry fruit (Morus alba L.) were investigated. In vitro, MFE showed potent α-glucosidase inhibitory activity and radical-scavenging activities against DPPH and superoxide anion radicals. In vivo, MFE could significantly decrease fasting blood glucose (FBG) and glycosylated serum protein (GSP), and increase antioxidant enzymatic activities (SOD, CAT, GSH-Px) in streptozotocin (STZ)-induced diabetic mice. Bioactivity-guided fractionation of the MFE led to the isolation of 25 phenolic compounds, and their structures were identified on the basis of MS and NMR data. All the 25 compounds were isolated from mulberry fruit for the first time. Also, the α-glucosidase inhibitory activity and antioxidant activity of the phenolics were evaluated. Potent α-glucosidase inhibitory and radical-scavenging activities of these phenolics suggested that they may be partially responsible for the antidiabetic and antioxidant activities of mulberry fruit.

Preliminary Phytochemical analysis and In vitro Antioxidant, FTIR Spectroscopy, Anti-diabetic activity of Acacia catechu ethanolic seed extract

“…23 From the reports on their potential effectiveness against diabetes, it can be assumed that the herbal remedies have a remarkable role to play in the management of diabetes, which needs further exploration for necessary development of drugs and nutraceuticals from natural resources.…”

Evaluation of Antioxidative and Antidiabetic Activity of Bark of Holarrhena Pubescens Wall

“…DM, characterized as genetically based predisposition and dietary indiscretion [2] is ranked seventh among the leading causes of death and third when it's fatal complications are taken into account [3,4]. There is increasing evidence that complications related to diabetes like retinopathy, atherosclerotic vascular disease are associated with oxidative stress induced by the generation of free radicals [5].…”

Synthesis and Biological Evaluation of 3-Benzylidene-4-chromanone Derivatives as Free Radical Scavengers and α-Glucosidase Inhibitors

“…Compound 1a was commercially available and compounds 1b and c were synthesized from resorcinol according to the procedure of Foroumadi et al 21) With 1a-c in hand, each was condensed with benzaldehyde derivatives (2a-h) in the presence of piperidine to provide the 3-benzylidene-4-chromanone derivatives (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

“…Recently, several researchers have evaluated α-glucosidase inhibitors exhibiting free-radical scavenging activity. [4][5][6][7][8][9] (3E)-3-Benzylidene-2,3-dihydro-4H-1-benzopyran-4-ones (3-benzylidene-4-chromanones) constitute a small class of natural products primarily isolated from Hyacinthaceae and Caesalpinioideae. [10][11][12][13][14] Several natural and synthetic 3-benzylidene-4-chromanones are related structurally to flavonoids and were found to possess various biological properties such as antioxidant, antifungal, antiviral, anti-mutagenic, antiproliferative, anti-allergic, antihistaminic, anti-inflammatory, and monoamine oxidase inhibitory activity.…”