Macromolecules as targeted drugs delivery vehicles: an overview

Ali, Yousaf; Alqudah, Ali Abdallah; Ahmad, Sadiq; Hamid, Shafida Abd; Farooq, Umar

doi:10.1080/15685551.2019.1591681

Cited by 20 publications

(9 citation statements)

References 43 publications

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“…These characteristics make polymeric micelles an important newgeneration nanomedicine with advanced diagnostic and therapeutic clinical applications. 49,50 Dendrimers are the other types of polymeric carriers for drug targeting. They are monodispersed macromolecules with well-articulated and structurally multibranched globular units.…”

Section: Polymeric Carriers For Tddssmentioning

confidence: 99%

“…These characteristics make polymeric micelles an important new-generation nanomedicine with advanced diagnostic and therapeutic clinical applications. 49 , 50 …”

Section: Vehicle/carrier Systems For Targeted Ddmentioning

confidence: 99%

“…Drug release is determined by the nature of the linkage. 49 For a successful dendrimer DDS, the critical nanoscale design parameters — particle size, shape, surface, flexibility/rigidity, architecture, and elemental composition — should be well considered. 51…”

Section: Vehicle/carrier Systems For Targeted Ddmentioning

confidence: 99%

“…TDD is aimed at managing and controlling the pharmacokinetics, pharmacodynamics, aspecific toxicity, immunogenicity, and biorecognition of therapeutic agents. 7 The end goal is improving treatment effectiveness while reducing side effects. TDDSs differ from conventional or traditional DDSs in that they acquire site-specific release of drugs from a dosage form, while the former depends on drug absorption through biological membranes.…”

Section: Introductionmentioning

confidence: 99%

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Targeted Drug Delivery — From Magic Bullet to Nanomedicine: Principles, Challenges, and Future Perspectives

Yayehrad¹,

Abate²,

Derseh³

et al. 2021

JMDH

180

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Nanomedicine is an advanced version of Paul Ehrlich's "magic bullet" concept. Targeted drug delivery is a system of specifying the drug moiety directly into its targeted body area (organ, cellular, and subcellular level of specific tissue) to overcome the aspecific toxic effect of conventional drug delivery, thereby reducing the amount of drug required for therapeutic efficacy. To achieve this objective, the magic bullet concept was developed and pushed scientists to investigate for more than a century, leading to the envisioning of different nanometer-sized devices -today's nanomedicine. Different carrier systems are being used and investigated, which include colloidal (vesicular and multiparticulate) carriers, polymers, and cellular/subcellular systems. This review addresses the need for and advantages of targeting, with its basic principles, strategies, and carrier systems. Recent advances, challenges, and future perspectives are also highlighted.

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Section: Polymeric Carriers For Tddssmentioning

confidence: 99%

“…These characteristics make polymeric micelles an important new-generation nanomedicine with advanced diagnostic and therapeutic clinical applications. 49 , 50 …”

Section: Vehicle/carrier Systems For Targeted Ddmentioning

confidence: 99%

Section: Vehicle/carrier Systems For Targeted Ddmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Targeted Drug Delivery — From Magic Bullet to Nanomedicine: Principles, Challenges, and Future Perspectives

Yayehrad¹,

Abate²,

Derseh³

et al. 2021

JMDH

180

View full text Add to dashboard Cite

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“…Non-toxic carriers transport the drug-loaded/attached to them safely to the desired site. Studies suggest that carriers/materials have non-toxic properties [42].…”

Section: Antiproliferative Activity On Hela Cell Line For Halloysite Poly(mpaema) and Their Nanocompositesmentioning

confidence: 99%

Preparation of poly(MPAEMA)/halloysite Nanocomposites and Investigation of Antiproliferative Activity

2021

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Abstract. In this present work, the synthesis, characterization, and thermal properties of poly(2-(4-methoxyphenylamino)-2-oxoethyl methacrylate) (MPAEMA) polymer/clay-based nanocomposites were investigated by in-situ polymerization. At the characterizations of nanomaterials FTIR, XRD, SEM, and TGA techniques were used. It was determined from XRD and SEM measurements that the morphology of nanocomposites was exfoliated when the clay content in the polymer matrix was kept at 3% and 5%. From thermal analysis, a positive correlation was observed between the clay ratio and thermal stability of nanomaterials. Also, the cytotoxic effect of halloysite and its nanocomposites was investigated using XTT assay on HeLa cells. According to the results, nanocomposites showed a non-cytotoxic response and thus they may use safety in many research areas such as medicine, agriculture, cosmetics. Resumen. En este trabajo, se reporta la síntesis, caracterización y propiedades térmicas de nanocompuestos de polímero / arcilla poli(2-(4-metoxifenilamino)-2-oxoetil metacrilato) (MPAEMA), obtenidos mediante polimerización in situ. Para caracterizar los nanomateriales se utilizaron las siguientes técnicas: FTIR, XRD, SEM y TGA. A partir de las mediciones de XRD y SEM se determinó que la morfología de los nanocompuestos muestra exfoliación, cuando el contenido de arcilla en la matriz de polímero se mantiene en 3% y 5%. Estudios mediante análisis térmico muestran una correlación positiva entre la relación de arcilla y la estabilidad térmica de los nanomateriales. También se investigó el efecto citotóxico de la halloysita y sus nanocompuestos utilizando el ensayo XTT en células HeLa. Los resultados muestran que los nanocompuestos tienen una respuesta no citotóxica y, por lo tanto, pueden utilizarse con seguridad en muchas áreas de investigación en disciplinas como la medicina, la agricultura y la cosmética.

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Prodrug Design to Enhance Bioavailability and Systemic Delivery

Sanches

Ferreira

2020

Healthy Ageing and Longevity

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Macromolecules as targeted drugs delivery vehicles: an overview

Cited by 20 publications

References 43 publications

Targeted Drug Delivery — From Magic Bullet to Nanomedicine: Principles, Challenges, and Future Perspectives

Targeted Drug Delivery — From Magic Bullet to Nanomedicine: Principles, Challenges, and Future Perspectives

Preparation of poly(MPAEMA)/halloysite Nanocomposites and Investigation of Antiproliferative Activity

Prodrug Design to Enhance Bioavailability and Systemic Delivery

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