Macromolecule content influences proton diffusibility in gliomas

Goebell, Einar; Fiehler, Jens; Siemonsen, Susanne; Vaeterlein, Ole; Heese, Oliver; Hagel, Christian; Ding, Xiao‐Qi; Buhk, Jan‐Hendrik; Groth, Michael; Kucinski, Thomas

doi:10.1007/s00330-011-2206-3

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…Adversely, in GBM patients and IDH-mutant astrocytoma CNS WHO Grade 4 the contrast-enhancing part of the tumor showed an opposite behavior with higher MD values in the seizure group. A generally increased MD in the TU ROI compared to distant white matter is in agreement with previous observations [ 27 ].…”

Section: Discussionsupporting

confidence: 93%

“…In a rat model of pilocarpine-induced status epilepticus, reductions in MD were observed several weeks after the seizure along with a decrease in myelin staining [ 31 ]. However, previous considerations about proton physics in glioma tissue would contradict this with the hypothesis that elevated apparent diffusion coefficient levels might be related to the loss of proteins, such as myelin [ 27 ]. Whether decreased MD of tumor tissue in seizure patients is related to cellular alterations or swelling leading to a reduction of extracellular space with reduced diffusion of protons and / or to changes of the composition of macromolecules binding protons needs to be clarified in further studies.…”

Section: Discussionmentioning

confidence: 99%

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Diffusion tensor imaging changes in patients with glioma-associated seizures

et al. 2022

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Introduction Structural white matter changes associated with certain epilepsy subtypes have been demonstrated using diffusion tensor imaging (DTI). This observational study aims to identify potential water diffusion abnormalities in glioma patients with associated seizures. Methods Two cohorts from two centers were analyzed independently: (A) Prospectively recruited patients diagnosed with glioma who received preoperative DTI to measure mean diffusivity (MD) and fractional anisotropy (FA) in regions-of-interest (ROIs) including the marginal tumor zone (TU), adjacent peritumoral white matter as well as distant ipsilateral and contralateral white matter and cortex. Data were compared between patients with and without seizures and tested for statistical significance. (B) A retrospective cohort using an alternative technical approach sampling ROIs in contrast enhancement, necrosis, non-enhancing tumor, marginal non-enhancing tumor zone, peritumoral tissue, edema and non-tumorous tissue. Results (A) The prospective study cohort consisted of 23 patients with 12 (52.2%) presenting with a history of seizures. There were no significant seizure-associated differences in MD or FA for non-tumor white matter or cortical areas. MD-TU was significantly lower in patients with seizures (p = 0.005). (B) In the retrospective cohort consisting of 46 patients with a seizure incidence of 50.0%, significantly decreased normalized values of MD were observed for non-enhancing tumor regions of non-glioblastoma multiforme (GBM) cases in patients with seizures (p = 0.022). Conclusion DTI analyses in glioma patients demonstrated seizure-associated diffusion restrictions in certain tumor-related areas. No other structural abnormalities in adjacent or distant white matter or cortical regions were detected.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging changes in patients with glioma-associated seizures

et al. 2022

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“…Tanner [25] first observed in 1983 that an increasing concentration of macromolecules is correlated with restriction of diffusion. This phenomenon has been evaluated in gliomas and encephalitis with positive results [15,26]. Gupta et al [10] found, by applying an MT pulse in diffusion weighted sequences in patients with brain abscess and other cystic lesions, that the saturation of protons causes an elevation of the ADC values.…”

Section: Patientsmentioning

confidence: 98%

Impact of Protein Content on Proton Diffusibility in Intracranial Cysts

Goebell

Fiehler

Martens

et al. 2012

Fortschr Röntgenstr

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“…The MTR of primary brain tumors has been shown to be reduced relative to normal brain in preclinical and clinical studies . In rat glioma models, the MTR has been shown to fall further with the development of the tumor .…”

Section: Introductionmentioning

confidence: 99%

Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases

Ainsworth

McIntyre

Honess

et al. 2016

Magnetic Resonance in Med

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PurposeThe sensitivity of the magnetization transfer ratio (MTR) and apparent diffusion coefficient (ADC) for early detection of brain metastases was investigated in mice and humans.MethodsMice underwent MRI twice weekly for up to 31 d following intracardiac injection of the brain‐homing breast cancer cell line MDA‐MB231‐BR. Patients with small cell lung cancer underwent quarterly MRI for 1 year. MTR and ADC were measured in regions of metastasis and matched contralateral tissue at the final time point and in registered regions at earlier time points. Texture analysis and linear discriminant analysis were performed to detect metastasis‐containing slices.ResultsCompared with contralateral tissue, mouse metastases had significantly lower MTR and higher ADC at the final time point. Some lesions were visible at earlier time points on the MTR and ADC maps: 24% of these were not visible on corresponding T2‐weighted images. Texture analysis using the MTR maps showed 100% specificity and 98% sensitivity for metastasis at the final time point, with 77% sensitivity 2–4 d earlier and 46% 5–8 d earlier. Only 2 of 16 patients developed metastases, and their penultimate scans were normal.ConclusionsSome brain metastases may be detected earlier on MTR than conventional T2; however, the small gain is unlikely to justify “predictive” MRI. Magn Reson Med 77:1987–1995, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Macromolecule content influences proton diffusibility in gliomas

Abstract: Our results suggest that macromolecules binding protons in their vicinity are a major determinant of proton diffusivity in brain tumours in addition to other factors such as mechanical barriers like membranes or the size of the extra-cellular space.

Cited by 6 publications

References 29 publications

Diffusion tensor imaging changes in patients with glioma-associated seizures

Diffusion tensor imaging changes in patients with glioma-associated seizures

Impact of Protein Content on Proton Diffusibility in Intracranial Cysts

Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases

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