Macromolecular Turnover in Brain during Aging

Stella, A. M. Giuffrida; Lajtha, Ábel

doi:10.1159/000212867

Cited by 29 publications

(3 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to enzymatic antioxidant defenses, cells possess low-molecular-weight, free radical scavengers such as vitamin E, reduced glutathione, cysteine, 0-carotene, and ascorbic acid (Fridovich, 1978) to decrease the content of free radical species (Tappel, 1973). Free radicals probably are involved in the inactivation of some enzymes (Lin and Armstrong, 1978;Kono and Fridovich, 1982), in the impairment of synthesis and metabolism of nucleic acids due to single-and double-strand DNA breaks (for review see Giuffrida-Stella and Lajtha, 1987), degradation of hyaluronic acid (McCord, 1984), and increased vascular permeability (Johnson et al,198 1). Cerebral mitochondria, particularly the intrasynaptic ones, represent a potent source of oxygen-free radicals, which are produced at the level of ubiquinonecytochrome b and NADH dehydrogenase complexes (Freeman and Crapo, 1982).…”

Section: Introductionmentioning

confidence: 99%

Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging

Vanella

Villa

Gorini

et al. 1989

J of Neuroscience Research

View full text Add to dashboard Cite

The specific activities of superoxide dismutase (SOD) and cytochrome oxidase (COX) in light and heavy synaptic mitochondria from rat cerebral cortex at different ages (4, 8, 12, 16, 20, and 24 months) have been measured. The specific activity of COX was significantly higher in light synaptic mitochondria than in heavy ones at all ages examined. However, no significant difference during aging was shown. A marked decrease of SOD in light and heavy synaptic mitochondria during aging was observed.

show abstract

Section: Introductionmentioning

confidence: 99%

Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging

Vanella

Villa

Gorini

et al. 1989

J of Neuroscience Research

View full text Add to dashboard Cite

show abstract

“…a similar pattern was observed in the brain of silver catfish transported in plastic bags for 7 h (azambuja et al 2011). The brain contains high amounts of unsaturated lipids and utilizes approximately 20 % of the total oxygen demand of the body (Stella and lajtha 1987). In hypoxic conditions, an inadequate oxygen supply to the brain may cause increased levels of lPO because the organism tends to primarily protect the vital organs (lushchak and Bagnyukova 2007).…”

Section: Plasma Ion Levelsmentioning

confidence: 99%

Humic acid and moderate hypoxia alter oxidative and physiological parameters in different tissues of silver catfish (Rhamdia quelen)

et al. 2014

View full text Add to dashboard Cite

Aquatic animals are naturally exposed simultaneously to environments with different concentrations of humic acid (HA) and seasonal or daily variations of dissolved oxygen (DO) levels. This study investigated the effects of simultaneous exposure to different HA and DO levels on plasma ion levels and some hematological and oxidative parameters in different tissues of silver catfish (Rhamdia quelen). The fish were exposed to 0, 2.5 or 5 mg L(-1) HA for 120 h. After this period, each group was divided into two groups: normoxia and hypoxia. Exposure to the different DO levels lasted 96 h, totaling 216 h of experimentation. At the end of the experimental period, blood sampling was performed, and the fish were euthanized prior to the excision of the gills and the brain to evaluate hematological and oxidative parameters. To verify the antioxidant capacity of HA, total phenolic compounds were measured. In general, all tissues of silver catfish exposed simultaneously to hypoxia and different HA concentrations showed a reduction in lipid peroxidation levels, as well as a modulation of the antioxidant system. These effects occurred in an HA concentration-dependent manner. Thus, HA is beneficial to silver catfish exposed to hypoxia. These beneficial effects can be attributed, most likely, to the action of the different HA constituents and functional groups, including phenolic compounds, which have antioxidant properties.

show abstract

“…Being highly aerobic they are the most likely candidates to suffer from oxidative stress caused by an imbalance between prooxidant activities of reactive oxygen species and antioxidant defenses. The presence of easily peroxidizable polyunsaturated fatty acids and poorly enriched antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) makes the brain more vulnerable to oxidative stress [15]. That aging results from an increase in oxidative stress has been established by various authors [16,17].…”

Section: Introductionmentioning

confidence: 99%

Age-Related Effect of Aluminium on the Catalase Activities of the Brains of Two Species of Poikilothermic Vertebrates

Jena

Nayak²,

Patnaik

2002

Gerontology

View full text Add to dashboard Cite

Background: Although aluminium (Al) has been implicated in various neuropathological states with aging due to its involvement in neurotoxicity, the exact role of the metal ion is still unclear. Objective: The aim of the present study is to ascertain whether the antioxidant enzymes of the brain protecting from oxidative damages which accumulate with aging are regulated by Al in an age-dependent manner. Method: The inhibitory effect of Al on the catalase activity of brain homogenates of two species of poikilothermic vertebrates was studied in vitro using a spectrophotometric method. Results: At a final concentration of 666 µM, the metal ion inhibited the enzyme activity of the brain in both species. In fish brain the degree of inhibition was not age-dependent. On the other hand, the rate of inhibition increased between young and middle-aged lizards followed by a decline in the old counterparts. Conclusion: Al inhibits catalase activity but this effect may not be a major contributing factor in the aging of the brain in the two species capable of maintaining their antioxidant capacity until old age.

show abstract

Macromolecular Turnover in Brain during Aging

Cited by 29 publications

References 51 publications

Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging

Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging

Humic acid and moderate hypoxia alter oxidative and physiological parameters in different tissues of silver catfish (Rhamdia quelen)

Age-Related Effect of Aluminium on the Catalase Activities of the Brains of Two Species of Poikilothermic Vertebrates

Contact Info

Product

Resources

About