Macromolecular fraction (MMF) from 3D ultrashort echo time cones magnetization transfer (3D UTE-Cones-MT) imaging predicts meniscal degeneration and knee osteoarthritis

Zhang, Xiaodong; Ma, Yajun; Wei, Zhao; Wu, Mei; Ashir, Aria; Jerban, Saeed; Li, Shaolin; Chang, Eric Y.

doi:10.1016/j.joca.2021.04.004

Cited by 12 publications

(7 citation statements)

References 36 publications

(37 reference statements)

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“…For meniscus, the reported average T 2 and T 1ρ values were changed 58.9% and 70.2%, respectively, in advanced OA patients compared with controls, 26 which are much higher than the FatSat‐induced

T_{2}^{*}

(2.0%) and T 1ρ (6.1%) changes in our study. Zhang et al also reported an average MMF change of 9.6% in meniscus for mild OA patients compared with controls, 27 which is much higher than that induced by FatSat (2.7%) in our study. Hodgson et al reported a 21.9% MMF change in the Achilles tendon for patients with psoriatic arthritis compared with controls, 28 and Zhu et al reported an average 26.8% MMF change in the rotator cuff tendon when comparing between patients with mild and severe tendinopathy 15 .…”

Section: Discussioncontrasting

confidence: 45%

On the fat saturation effect in quantitative ultrashort TE MR imaging

Chen

Liang

et al. 2022

Magnetic Resonance in Med

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Purpose: To investigate the effect of fat saturation (FatSat) on quantitative UTE imaging of variable knee tissues on a 3T scanner.Methods: Three quantitative UTE imaging techniques, including the UTE multiecho sequence for T * 2 measurement, the adiabatic T 1ρ prepared UTE sequence for T 1ρ measurement, and the magnetization transfer (MT)-prepared UTE sequence for MT ratio (MTR) and macromolecular proton fraction (MMF) measurements were used in this study. Twelve samples of cartilage and twelve samples of meniscus, as well as six whole knee cadaveric specimens, were imaged with the three above-mentioned UTE sequences with and without FatSat. The difference, correlation, and agreement between the UTE measurements with and without FatSat were calculated to investigate the effects of FatSat on quantification.Results: Fat was well-suppressed using all three UTE sequences when FatSat was deployed. For the small sample study, the quantification difference ratio (QDR) values of all the measured biomarkers ranged from 0.7% to 12.6%, whereas for the whole knee joint specimen study, the QDR values ranged from 0.2% to 12.0%. Except for T 1ρ in muscle and MMF in meniscus (p > 0.05), most of the measurements showed statistical differences for T 1ρ , MTR, and MMF (p < 0.05) between FatSat and non-FatSat scans. Most of the measurements for T * 2 showed no significant differences (p > 0.05). Strong correlations were found for all the biomarkers between measurements with and without FatSat. Conclusion:The UTE biomarkers showed good correlation and agreement with some slight differences between the scans with and without FatSat.

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T_{2}^{*}

Section: Discussioncontrasting

confidence: 45%

On the fat saturation effect in quantitative ultrashort TE MR imaging

Chen

Liang

et al. 2022

Magnetic Resonance in Med

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“…As such, the multispoke 3D UTE‐MT technique has been used to evaluate knee joint degeneration in vivo with a total scan time of less than 15 minutes. Decreased MMF and MTR were observed for cartilage and meniscus in mild and advanced OA as compared to healthy subjects 93,94 …”

Section: Part Ii: Quantitative Ute Imagingmentioning

confidence: 97%

“…Decreased MMF and MTR were observed for cartilage and meniscus in mild and advanced OA as compared to healthy subjects. 93,94 UTE Quantitative Susceptibility Mapping Quantitative susceptibility mapping (QSM) has recently emerged as a promising technique that allows characterization of tissue based on its magnetic susceptibility. 95 QSM can estimate the spatial susceptibility distribution from a measured field perturbance using nonlinear optimization techniques.…”

Section: Ute Magnetization Transfer Imagingmentioning

confidence: 99%

“…74,[76][77][78] The magic angleassociated increase in T1ρ, T2, or T2* can be significantly higher than the increase caused by degeneration. Magic angle-insensitive techniques such as UTE-AdiabT1ρ [79][80][81][82] and UTE-MT modeling of MMF, [87][88][89][90][91][92][93][94] are of particular interest for robust assessment of short-T2 tissue degeneration. Direct imaging of short-T2 tissues can be used to improve diagnosis of OA and other MSK diseases.…”

Section: Part Iii: Challenges and Future Workmentioning

confidence: 99%

“…The magic angle‐associated increase in T1ρ, T2, or T2* can be significantly higher than the increase caused by degeneration. Magic angle‐insensitive techniques such as UTE‐AdiabT1ρ 79–82 and UTE‐MT modeling of MMF, 87–94 are of particular interest for robust assessment of short‐T2 tissue degeneration.…”

Section: Part Iii: Challenges and Future Workmentioning

confidence: 99%

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Ultrashort Echo Time Magnetic Resonance Imaging Techniques: Met and Unmet Needs in Musculoskeletal Imaging

Afsahi

Jang

et al. 2021

Magnetic Resonance Imaging

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This review article summarizes recent technical developments in ultrashort echo time (UTE) magnetic resonance imaging of musculoskeletal (MSK) tissues with short-T2 relaxation times. A series of contrast mechanisms are discussed for highcontrast morphological imaging of short-T2 MSK tissues including the osteochondral junction, menisci, ligaments, tendons, and bone. Quantitative UTE mapping of T1, T2*, T1ρ, adiabatic T1ρ, magnetization transfer ratio, MT modeling of macromolecular proton fraction, quantitative susceptibility mapping, and water content is also introduced. Met and unmet needs in MSK imaging are discussed.

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