On the fat saturation effect in quantitative ultrashort TE MR imaging

Chen, Yanjun; Liang, Li; Le, Nicole; Chang, Eric Y.; Huang, Wenhua; Ma, Yajun

doi:10.1002/mrm.29149

Cited by 8 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A range of MMF values in muscles has been reported in the literature. In human lower extremity muscles, values generally range from 6% to 9%, 14,18,40 whereas values between 12% and 17% have been reported in pigs and cattle. 15,41 Thus, the MMF values we obtained in the rat rotator cuff muscles are within the expected range, although are probably underestimated in the injured shoulders due to residual edema.…”

Section: Discussionmentioning

confidence: 98%

Rotator cuff muscle fibrosis can be assessed using ultrashort echo time magnetization transfer MRI with fat suppression

Chang,

Suprana,

Tang

et al. 2023

NMR in Biomedicine

Self Cite

View full text Add to dashboard Cite

Muscle degeneration following rotator cuff tendon tearing is characterized by fatty infiltration and fibrosis. While tools exist for the characterization of fat, the ability to noninvasively assess muscle fibrosis is limited. The purpose of this study was to evaluate the capability of quantitative ultrashort echo time T1 (UTE‐T1) and UTE magnetization transfer (UTE‐MT) mapping with and without fat suppression (FS) for the differentiation of injured and control rotator cuff muscles and for the detection of fibrosis. A rat model of chronic massive rotator cuff tearing (n = 12) was used with tenotomy of the right supraspinatus and infraspinatus tendons and silicone implants to prevent healing. Imaging was performed on a 3‐T scanner, and UTE‐T1 mapping with and without FS and UTE‐MT with and without FS for macromolecular fraction (MMF) mapping was performed. At 20 weeks postinjury, T1 and MMF were measured in the supraspinatus and infraspinatus muscles of the injured and contralateral, internal control sides. Histology was performed and connective tissue fraction (CTF) was measured, defined as the area of collagen‐rich extracellular matrix divided by the total muscle area. Paired t‐tests and correlation analyses were performed. Significant differences between injured and control sides were found for CTF in the supraspinatus (mean ± SD, 14.5% ± 3.9% vs. 11.3% ± 3.7%, p = 0.01) and infraspinatus (17.0% ± 5.4% vs. 12.5% ± 4.6%, p < 0.01) muscles, as well as for MMF using UTE‐MT FS in the supraspinatus (9.7% ± 0.3% vs. 9.5% ± 0.2%, p = 0.04) and infraspinatus (10.9% ± 0.8% vs. 10.1% ± 0.5%, p < 0.01) muscles. No significant differences between sides were evident for T1 without or with FS or for MMF using UTE‐MT. Only MMF using UTE‐MT FS was significantly correlated with CTF for both supraspinatus (r = 0.46, p = 0.03) and infraspinatus (r = 0.51, p = 0.01) muscles. Fibrosis occurs in rotator cuff muscle degeneration, and the UTE‐MT FS technique may be helpful to evaluate the fibrosis component, independent from the fatty infiltration process.

show abstract

Section: Discussionmentioning

confidence: 98%

Rotator cuff muscle fibrosis can be assessed using ultrashort echo time magnetization transfer MRI with fat suppression

Chang,

Suprana,

Tang

et al. 2023

NMR in Biomedicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this study, a conventional fat-saturation module was employed to suppress fat. Chen et al [41] demonstrated that these conventional fat saturation modules could decrease T1ρ in short T2 tissues, such as the quadriceps tendon, by approximately 9%. This reduction could be attributed to the broad frequency spectrum of these tissues, which might be in proximity to or overlapping with the signal peaks from fat.…”

Section: Discussionmentioning

confidence: 99%

Bi-Exponential 3D UTE-T1ρ Relaxation Mapping of Ex Vivo Human Knee Patellar Tendon at 3T

Malhi,

Moazamian,

Shin

et al. 2024

Bioengineering

View full text Add to dashboard Cite

Introduction: The objective of this study was to assess the bi-exponential relaxation times and fractions of the short and long components of the human patellar tendon ex vivo using three-dimensional ultrashort echo time T1ρ (3D UTE-T1ρ) imaging. Materials and Methods: Five cadaveric human knee specimens were scanned using a 3D UTE-T1ρ imaging sequence on a 3T MR scanner. A series of 3D UTE-T1ρ images were acquired and fitted using single-component and bi-component models. Single-component exponential fitting was performed to measure the UTE-T1ρ value of the patellar tendon. Bi-component analysis was performed to measure the short and long UTE-T1ρ values and fractions. Results: The single-component analysis showed a mean single-component UTE-T1ρ value of 8.4 ± 1.7 ms for the five knee patellar tendon samples. Improved fitting was achieved with bi-component analysis, which showed a mean short UTE-T1ρ value of 5.5 ± 0.8 ms with a fraction of 77.6 ± 4.8%, and a mean long UTE-T1ρ value of 27.4 ± 3.8 ms with a fraction of 22.4 ± 4.8%. Conclusion: The 3D UTE-T1ρ sequence can detect the single- and bi-exponential decay in the patellar tendon. Bi-component fitting was superior to single-component fitting.

show abstract

“…Chen et al. investigated the effects of fat saturation on three quantitative UTE images including

, T 1ρ , and MT ( 59 ). These sequences were implemented with and without fat saturation on knee cartilage samples and whole cadaveric knee specimens at 3T.…”

Section: Ute With Fat Suppressionmentioning

confidence: 99%

Articular Cartilage Assessment Using Ultrashort Echo Time MRI: A Review

et al. 2022

View full text Add to dashboard Cite

Articular cartilage is a major component of the human knee joint which may be affected by a variety of degenerative mechanisms associated with joint pathologies and/or the aging process. Ultrashort echo time (UTE) sequences with a TE less than 100 µs are capable of detecting signals from both fast- and slow-relaxing water protons in cartilage. This allows comprehensive evaluation of all the cartilage layers, especially for the short T2 layers which include the deep and calcified zones. Several ultrashort echo time (UTE) techniques have recently been developed for both morphological imaging and quantitative cartilage assessment. This review article summarizes the current catalog techniques based on UTE Magnetic Resonance Imaging (MRI) that have been utilized for such purposes in the human knee joint, such as T1, T2∗, T1ρ, magnetization transfer (MT), double echo steady state (DESS), quantitative susceptibility mapping (QSM) and inversion recovery (IR). The contrast mechanisms as well as the advantages and disadvantages of these techniques are discussed.

show abstract

On the fat saturation effect in quantitative ultrashort TE MR imaging

Cited by 8 publications

References 36 publications

Rotator cuff muscle fibrosis can be assessed using ultrashort echo time magnetization transfer MRI with fat suppression

Rotator cuff muscle fibrosis can be assessed using ultrashort echo time magnetization transfer MRI with fat suppression

Bi-Exponential 3D UTE-T1ρ Relaxation Mapping of Ex Vivo Human Knee Patellar Tendon at 3T

Articular Cartilage Assessment Using Ultrashort Echo Time MRI: A Review

Contact Info

Product

Resources

About