Macrolides for the prevention and treatment of feeding intolerance in preterm low birth weight infants: a systematic review and meta-analysis

Basu, Sriparna; Smith, Susan

doi:10.1007/s00431-020-03814-1

Cited by 12 publications

(10 citation statements)

References 59 publications

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“… 18 - 21 Interestingly, erythromycin prophylaxis is also beneficial in the treatment of feeding intolerance in preterm low birth weight infants. 22 …”

Section: Discussionmentioning

confidence: 99%

“…[18][19][20][21] Interestingly, erythromycin prophylaxis is also beneficial in the treatment of feeding intolerance in preterm low birth weight infants. 22 Limitation of the study: The main limitation is that the ex vivo technique is a complex system and expensive and always there were uncontrolled conditions that led to the discontinuation of the experiment and also the availability of the intact placenta. Due to a lack of data regarding placenta transport of antibiotics, our findings may support clinicians' use of erythromycin in the obstetric field.…”

Section: A H E a D O F P R I N Tmentioning

confidence: 99%

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Placental transport of Erythromycin and its effect on placental inflammatory factors

Elbiss

Osman²

2022

Pak J Med Sci

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Objective: Erythromycin is used for prevention and control of infectious perinatal morbidity. It has been hypothesised that erythromycin crosses the placenta and has an effect on the production of placental inflammatory factors. We evaluated the transport of erythromycin in an ex-vivo closed perfusion system of the placenta and determined its effect on the production of placenta inflammatory markers. Methods: In 2013, a prospective basic science study was conducted at the placental laboratory of College of Medicine and Health Sciences, United Arab Emirates. Six term placentas from uncomplicated pregnancies were studied using the ex-vivo dual closed-loop human placental cotyledon perfusion technique. Erythromycin was added to the perfusate in the maternal compartment. Samples were obtained from the maternal and fetal up to 240 minutes. Results: The reference antipyrine was detected in the fetal circulation in the first 15 minutes after addition of the drug. At this point the mean antipyrine was 49.90±2.10µg/ml in the maternal perfusate and 7.1±1.56µg/ml in fetal perfusate. The fetal and maternal concentration became similar at 120 minutes. The transfer of antipyrine from maternal to fetal compartment was 98.66%. The differences between perfusion groups were non-significant that indicates the perfusion of placentas was comparable. After media exchange in both sides, erythromycin was added to the maternal perfusate. The experimental period of four hours was continued with medium circulation on both maternal and fetal circulation. The concentration of erythromycin decreased in the maternal circuit by 36.4% and increased in the fetal circuit by 65%. The concentration of IL-6 in the maternal circuit was normal. Conclusion: Erythromycin crossed the placenta and did not inhibit the production of IL-6. Future studies are needed concerning neonatal adverse effects and the development of antibiotic resistance. doi: https://doi.org/10.12669/pjms.39.1.6683 How to cite this: Elbiss H, Osman N. Placental transport of Erythromycin and its effect on placental inflammatory factors. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6683 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“… 18 - 21 Interestingly, erythromycin prophylaxis is also beneficial in the treatment of feeding intolerance in preterm low birth weight infants. 22 …”

Section: Discussionmentioning

confidence: 99%

Section: A H E a D O F P R I N Tmentioning

confidence: 99%

Placental transport of Erythromycin and its effect on placental inflammatory factors

Elbiss

Osman²

2022

Pak J Med Sci

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“…The planned formula is for 100 mL of the nal volume of the product. The amount of erythromycin ethyl succinate used follows a single-use dose of 250 mg (Basu and Smith, 2021;Martingano et al, 2020). The amounts of PVA, polysorbate 80, and PEG-400 are based on previous studies where surfactant and cosurfactant form emulsion.…”

Section: Lipid Nanoparticle Formulationmentioning

confidence: 99%

Formulation and Evaluation of Solid Lipid Nanoparticles Loading Erythromycin Ethylsuccinate by Heating Emulsification and Homogenization Methods

Mardiyanto

Untari

Mara

et al. 2022

Sci. Technol. Indones

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The pandemic period has caused antibiotics highly recommended to cure infections. The use of macrolide antibiotics has greatly increased recently due to outbreaks of diseases that attack the human respiratory tract all of part of the world. One member of the macrolide group is erythromycin ethyl succinate which has low solubility in water. Therefore, this study aims to convert erythromycin ethyl succinate into lipid nanoparticles in an attempt to increase solubility. The method for the formation of nanoparticles is heating emulsification and homogenization. The results obtained in the form of formula 1 (F1) showed the percent encapsulation of 85.688±0.30641. The physical properties were that it has a size of 398.9±1.4 nm, a PDI of 0.3895±0.0015, and zeta potential of -17.45±0.15 mV respectively. The stability was determined by an accelerated test by the influence of extreme temperature and mechanics affecting the stability of the particles as an indication of decreasing the pH and particle precipitation. The solubility of erythromycin ethyl succinate in the form of lipid nanoparticles was increased in a comparison with the pure substance of erythromycin ethyl succinate.

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“…Motility agents such as erythromycin have been used in severe cases of feeding intolerance with dysmotility. Erythromycin is not recommended in preterm infants <32 weeks [ 86 ], while its role >32 weeks for feeding intolerance is debated with mixed results in previous studies [ 87 , 88 ]. Additionally, the adverse effects of erythromycin include alteration of the gut microbiome, antibiotic resistance, and infantile hypertrophic pyloric stenosis [ 89 ].…”

Section: Addressing Oral Feeding Issues Earlymentioning

confidence: 99%

Feeding Problems and Long-Term Outcomes in Preterm Infants—A Systematic Approach to Evaluation and Management

2021

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Preterm infants are known to have long-term healthcare needs. With advances in neonatal medical care, younger and more preterm infants are surviving, placing a subset of the general population at risk of long-term healthcare needs. Oral feeding problems in this population often play a substantial yet under-appreciated role. Oral feeding competency in preterm infants is deemed an essential requirement for hospital discharge. Despite achieving discharge readiness, feeding problems persist into childhood and can have a residual impact into adulthood. The early diagnosis and management of feeding problems are essential requisites to mitigate any potential long-term challenges in preterm-born adults. This review provides an overview of the physiology of swallowing and oral feeding skills, disruptions to oral feeding in preterm infants, the outcomes of preterm infants with feeding problems, and an algorithmic approach to the evaluation and management of neonatal feeding problems.

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Macrolides for the prevention and treatment of feeding intolerance in preterm low birth weight infants: a systematic review and meta-analysis

Cited by 12 publications

References 59 publications

Placental transport of Erythromycin and its effect on placental inflammatory factors

Placental transport of Erythromycin and its effect on placental inflammatory factors

Formulation and Evaluation of Solid Lipid Nanoparticles Loading Erythromycin Ethylsuccinate by Heating Emulsification and Homogenization Methods

Feeding Problems and Long-Term Outcomes in Preterm Infants—A Systematic Approach to Evaluation and Management

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