Formulation and Evaluation of Solid Lipid Nanoparticles Loading Erythromycin Ethylsuccinate by Heating Emulsification and Homogenization Methods

Abstract

The pandemic period has caused antibiotics highly recommended to cure infections. The use of macrolide antibiotics has greatly increased recently due to outbreaks of diseases that attack the human respiratory tract all of part of the world. One member of the macrolide group is erythromycin ethyl succinate which has low solubility in water. Therefore, this study aims to convert erythromycin ethyl succinate into lipid nanoparticles in an attempt to increase solubility. The method for the formation of nanoparticles is heating emulsification and homogenization. The results obtained in the form of formula 1 (F1) showed the percent encapsulation of 85.688±0.30641. The physical properties were that it has a size of 398.9±1.4 nm, a PDI of 0.3895±0.0015, and zeta potential of -17.45±0.15 mV respectively. The stability was determined by an accelerated test by the influence of extreme temperature and mechanics affecting the stability of the particles as an indication of decreasing the pH and particle precipitation. The solubility of erythromycin ethyl succinate in the form of lipid nanoparticles was increased in a comparison with the pure substance of erythromycin ethyl succinate.

Formation of Hydroxyl-Amide Solid Dispersion Involving Azithromycin and Chitosan-Alginate Biopolymer to Increase the Dissolution Rate of Azithromycin

“…Macrolides are large molecular weight antibiotics that have an amine group (Jednačak et al, 2020;Myers and Clark, 2021;Yuan et al, 2021;Mardiyanto et al, 2022a;Mardiyanto et al, 2022b) have low solubility in water (Echeverría Esnal et al, 2021;Jiang et al, 2014;Rajbhar et al, 2016;Vangala et al, 2012). Low solubility has an impact on low bioavailability Of the total discovery of new drug compounds, it is known that 70% have low solubility in water (Bhalani et al, 2022;Khatri Figure 1.…”