Macrolide-Resistant and Macrolide-Sensitive Mycoplasma pneumoniae Pneumonia in Children Treated Using Early Corticosteroids

Han, Hye Young; Park, Ki Cheol; Yang, Eun Ae; Lee, Kyung-Yil

doi:10.3390/jcm10061309

Cited by 12 publications

(15 citation statements)

References 32 publications

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“…73) Previous studies have reported that the macrolide-resistant M. pneumoniae (MRMP) rate has been rising continuously and rapidly in Korea. The MRMP rate in 2011 was 51.6-62.9%, 74,75) but 60-87% of children reportedly had the A2063G mutation during 2018-2020 in Korea, [76][77][78] which is in agreement with the findings of the present study. M. pneumoniae has a high prevalence in Asia,…”

Section: A C C E P T E D a R T I C L Esupporting

confidence: 92%

Epidemiology and surveillance implications of community-acquired pneumonia in children

2022

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Community-acquired pneumonia (CAP) is the single largest infectious cause of hospitalization and death in children worldwide. With improved immunizations, the incidence of bacterial pneumonia and the number of colonized bacteria have decreased. However, respiratory viruses are still an important cause of CAP, especially as new infectious agents such severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge. The SARS-CoV-2 virus emerged in 2019 and caused the current coronavirus disease 2019 pandemic. Therefore, it is necessary to elucidate the epidemiology and causative pathogens of CAP. Recently, the Pneumonia and Respiratory Disease Study Group, affiliated with the Korean Academy of Pediatric Allergy and Respiratory Disease, investigated the causative pathogens of respiratory infections in children hospitalized with CAP, the serotype of Streptococcus pneumoniae, and the prevalence of Mycoplasma pneumoniae with gene mutations. Antibiotic resistance and serotype test results can determine the use of empirical antibiotics. Moreover, it is possible to help develop future vaccines by comparing bacterial culture results with vaccine serotype and identifying the changes and prevalence of each serotype. Therefore, we will perform continuous national surveillance and monitor the epidemiology of respiratory pathogens in Korea and worldwide. The surveillance of these respiratory infections can play a role in monitoring the emergence of new infectious diseases such as SARS-CoV-2.

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Section: A C C E P T E D a R T I C L Esupporting

confidence: 92%

Epidemiology and surveillance implications of community-acquired pneumonia in children

2022

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“…Meanwhile, some other studies have demonstrated that MRMP pneumonia might respond to macrolide treatment, and there was no difference in clinical or laboratory variables between MRMP and MSMP pneumonia. 9,11,12 Additionally, coinfection with M. pneumoniae and other respiratory pathogens are common, but it is not wellknown whether coinfection is related to the severity of illness. 13 The complicated relationship between hospital admission and these different factors and their relative importance remains unclear in children with M. pneumoniae pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Assessment of variables associated with prolonged admission duration in children with Mycoplasma pneumoniae pneumonia

Sung

Roh

Lee

et al. 2022

Clinical Respiratory J

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Introduction Macrolide‐resistant Mycoplasma pneumoniae (MRMP) has become prevalent in children. This study investigated the clinical and laboratory variables of MRMP and macrolide‐sensitive M. pneumoniae (MSMP) and identified factors associated with prolonged hospital admission in children. Methods A prospective multicenter study was conducted in 1063 children <18 years old in July 2018–June 2020. The 454 had a positive M. pneumoniae polymerase chain reaction assay. Results Most subjects had MRMP (78.4%), and all mutated strains had the A2063G transition. We defined MRMP* (n = 285) as MRMP pneumonia requiring admission and MSMP* (n = 72) as MSMP pneumonia requiring admission. Patients with MRMP pneumonia were older, more likely to have segmental/lobar pneumonia, and had more febrile days than those with MSMP pneumonia. C‐reactive protein (CRP), lactate dehydrogenase (LDH), and percentage neutrophils were more strongly associated with MRMP* than MSMP* groups. Percentage neutrophils, CRP, and alanine aminotransferase significantly changed between admission and follow‐up measurements in patients with MRMP* (P < 0.05). The duration of admission positively correlated with the number of febrile days after initiation of antibiotic medication and laboratory variables (white blood cell count, CRP, and aspartate aminotransferase [AST]) (P < 0.05). Random forest analysis indicated that the number of febrile days after initiation of antibiotic medication, AST, and percentage neutrophils at admission was over five. Conclusions This study indicated that children with M. pneumoniae pneumonia with a higher number of febrile days after initiation of antibiotic medication, AST, and percentage neutrophils at admission were more likely to have prolonged admission duration.

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“…On the other hand, misdiagnosis of the disease can lead to negative health consequences, psychological distress and financial costs. Therefore, it is very important to use a correct, accurate and timely diagnostic method for this disease (19).…”

Section: Discussionmentioning

confidence: 99%

Comparison between the molecular diagnostic test and chest X-ray combined with multi-slice spiral CT in the diagnosis of lobar pneumonia

Zhu

Dong

Xie

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Lobar pneumonia is an inflammatory condition of the lung that mainly affects the lobes of the lungs and the alveoli, and it is usually caused by a bacterial infection. There are many ways to diagnosis this disease. But an early and accurate method for lobar pneumonia diagnosis has an important role in its treatment. Therefore, in this study, a comparison between the molecular diagnostic test and chest x-ray combined with multi-slice spiral CT was done to find out better diagnosis of lobar pneumonia. For this purpose, 122 individuals suspected of lobar pneumonia were studied by clinical examination, chest X-ray, and multi-slice spiral CT. For the molecular diagnosis test, the multiplex PCR was used for two main causes of the disease, Streptococcus pneumoniae and Klebsiella pneumoniae. Results showed that the specificity for Chest X-ray + Multi-slice Spiral CT had the highest amount (82.8%), but high sensitivity (100%) belonged to a molecular diagnostic test for both bacteria. On the other hand, the sensitivity and specificity of Streptococcus pneumoniae were better than Klebsiella pneumoniae and the possibility of error in Streptococcus pneumoniae was lower than Klebsiella pneumoniae. In general, although the Chest X-ray + Multi-slice Spiral CT method was better than the molecular diagnosis test, it could not identify the causative agent and did not show a difference between pathogens for better antibiotic treatment, and also the possibility of diagnosis is low at the beginning of the disease. Therefore, according to the results of the current study, the best way to diagnose lobar pneumonia is to use both methods, simultaneously.

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Macrolide-Resistant and Macrolide-Sensitive Mycoplasma pneumoniae Pneumonia in Children Treated Using Early Corticosteroids

Cited by 12 publications

References 32 publications

Epidemiology and surveillance implications of community-acquired pneumonia in children

Epidemiology and surveillance implications of community-acquired pneumonia in children

Assessment of variables associated with prolonged admission duration in children with Mycoplasma pneumoniae pneumonia

Comparison between the molecular diagnostic test and chest X-ray combined with multi-slice spiral CT in the diagnosis of lobar pneumonia

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