Macroglossia as a presenting feature of multiple myeloma

Abstract

Macroglossia has been very rarely reported as a first clinical sign of multiple myeloma.

Multiple Myeloma Diagnosed from Tongue Amyloidosis: A Case Report

“…Babajews [7] reported a case of tongue amyloidosis that was diagnosed to have multiple myeloma, based on multiple tests for the presence of M protein; in this case, the diagnosis was obtained after two examinations that were performed 3 months apart. Therefore, a negative initial examination does not necessarily rule out multiple myeloma, and performing a repeat examination is important [13][14][15][16][17][18][19][20][21].…”

Macroglossia reveals multiple myeloma

“…It is important to consider amyloidosis in the diagnostic process on account of its association with multiple myeloma, found in 15-20% of the cases, 2 though macroglossia has been rarely reported as first sign of multiple myeloma (MM). 3 MM is a malignant neoplasm of the bone marrow which is characterized by the proliferation of bone marrow plasma cells producing monoclonal immunoglobulins or light chains. These light chains are known as Bence-Jones proteins, which are excreted in the urine and are a diagnostic feature of multiple myeloma.…”

Macroglosia en Amiloidosis Primaria como Clave Diagnostica: Reporte de un Caso

“…Macroglosia se define como el aumento anormal en el tamaño de la lengua, clínicamente se presenta indolora con indentaciones en sus caras laterales y detritus alimenticio. Se categoriza en dos grandes grupos, macroglosia verdadera y pseudomacroglosia, la primera presente en patologías congénitas y adquiridas con hipertrofia real de tejido muscular y conectivo, generalmente causado por infiltrado proteico o glicógeno (Demirkan et al, 2017).…”

“…Su principal complicación es la disfagia, malnutrición, disartria y compresión de vías aéreas (Demirkan et al;Oruba et al, 2018). Dentro de las patologías adquiridas que pueden causar macroglosia se encuentra la amiloidosis, una rara condición presente en un gran espectro de enfermedades que tienen en común el deposito de agregado extracelular de proteínas llamado amiloide.…”