Multiple Myeloma Diagnosed from Tongue Amyloidosis: A Case Report

Uesugi, Atsushi

doi:10.37421/jbl.2019.9.237

Cited by 2 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The appearance of the patient's tongue led us to consider systemic amyloidosis as a differential diagnosis. There are many case reports of tongue amyloidosis with multiple myeloma [ [13] , [14] , [15] ], and tongue amyloidosis indeed leads the final diagnosis of multiple myeloma in the literature [ 13 ]. Although pathological diagnosis of tongue amyloidosis was not made in this case, it is highly plausible that the patient had tongue amyloidosis.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary amyloidosis complicated with pulmonary hemosiderosis, diagnosed with bronchoscopy

Ogo

Yanagihara

Nishimura

et al. 2021

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

We describe a case of an 82-year-old Japanese woman with pulmonary amyloidosis and hemosiderosis associated with multiple myeloma. She had a background of end-stage renal failure of unknown etiology and had been on maintenance dialysis for 2 years. She complained of exertional dyspnea for four months. High-resolution CT of the chest revealed diffuse ground-glass opacities with mosaic attenuation, consolidation in the left lingular lobe, and wedge-shaped, subpleural nodules in the bilateral lower lobes. A transbronchial lung biopsy of the left lingular lobe showed deposition of amorphous, eosinophilic amyloid at the smooth muscle layer of bronchial tissue, with a positive Congo red staining signal in polarized light. Bronchoalveolar lavage fluid was brownish-yellow, and numerous hemosiderin-laden macrophages were detected with Berlin blue staining. From these findings, a diagnosis of pulmonary amyloidosis complicated with pulmonary hemosiderosis was made. Further work-up led to a diagnosis of multiple myeloma. Pulmonary amyloidosis complicated with pulmonary hemosiderosis is a rare disorder and may be underdiagnosed. Physical examination, such as the appearance of the tongue, can assist the diagnosis of systemic amyloidosis. Use of bronchoscopy allows physicians make an early diagnosis of pulmonary amyloidosis that is minimally invasive.

show abstract

Section: Discussionmentioning

confidence: 99%

Pulmonary amyloidosis complicated with pulmonary hemosiderosis, diagnosed with bronchoscopy

Ogo

Yanagihara

Nishimura

et al. 2021

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

show abstract

“…True macroglossia is common in amyloidosis which is a rare progressive disorder that includes a group of diseases characterized by aggregation of at least 31 different amyloid proteins 10 and subsequently the accumulation of pathologic deposits of amyloids in the tissues. 11 The amyloids are protein polymers made of identical monomer units. Pathological amyloids usually consist of misfolded proteins.…”

Section: Discussionmentioning

confidence: 99%

Macroglossia reveals multiple myeloma

et al. 2021

View full text Add to dashboard Cite

We present an eighty-year old man with a one year history of progressive macroglossia, dysphagia and loss of weight. He had a medical history of arterial hypertension and prostatic hypertrophy which he had under good therapeutic control. The entire tongue was swollen, had hard solidity and was slightly painful upon palpation. A tongue biopsy revealed an amyloid deposition as it coloured bright orange-red on Congo Red staining and lead us subsequently to the diagnosis of amyloidosis; then a bone marrow biopsy confirmed the diagnosis of multiple myeloma. The case was further evaluated by a multidisciplinary team who considered it appropriate to start a lowdose melphalan treatment combined with supportive care. When macroglossia in the tongue is confirmed to be amyloidosis the differential diagnosis should include systemic amyloidosis deposition and multiple myeloma.

show abstract

Multiple Myeloma Diagnosed from Tongue Amyloidosis: A Case Report

Cited by 2 publications

References 13 publications

Pulmonary amyloidosis complicated with pulmonary hemosiderosis, diagnosed with bronchoscopy

Pulmonary amyloidosis complicated with pulmonary hemosiderosis, diagnosed with bronchoscopy

Macroglossia reveals multiple myeloma

Contact Info

Product

Resources

About