Macrodystrophia lipomatosa of foot involving great toe

Gaur, Anil; Mhambre, Amit Subhash; Popalwar, H.; Sharma, Rajesh

doi:10.1016/j.foot.2014.03.003

Cited by 2 publications

(3 citation statements)

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“…It is characterized by the proliferation of all the mesenchymal elements of the digits and a disproportionate increase of fibroadipose tissue. Distal limb involvement is usually observed (1)(2)(3)(4) and the involvement of the lower limbs is more common than that of the upper limbs. Notably, the second and third digits are the most commonly affected.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, the second and third digits are the most commonly affected. Macrodystrophia lipomatosa usually presents at birth or during the neonatal period (2). No gender predilection exists, however, a marginal preponderence is observed in males (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Macrodystrophia lipomatosa usually presents at birth or during the neonatal period (2). No gender predilection exists, however, a marginal preponderence is observed in males (1,2). Due to the rarity of macrodystrophia lipomatosa, the incidence is unknown.The etiology of macrodystrophia lipomatosa remains unclear, however, neurofibromatosis and lipomatous degeneration have been hypothesized to be involved (1).…”

Section: Introductionmentioning

confidence: 99%

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Macrodystrophia lipomatosa of the foot: A case report

2015

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Abstract. Macrodystrophia lipomatosa is a sporadic, nonhereditary developmental anomaly and a rare form of congenital localized gigantism. It is characterized by the proliferation of all the mesenchymal elements of a digit or digits, and a disproportionate increase of fibroadipose tissue involving the nerve sheath, muscle, periosteum and bone marrow. In the present study, a 9-month-old boy was referred to Gazi University Hospital (Ankara, Turkey) with congenital unilateral enlargement of the right forefoot, particularly involving the second and third toes. X-ray and magnetic resonance imaging (MRI) scans were performed in order to assess the skeletal structures. The present study described the characteristic imaging features, with an emphasis on the MRI findings, of this rare congenital form of gigantism.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Macrodystrophia lipomatosa of the foot: A case report

2015

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Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review

Marek

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Syal

et al. 2020

Journal of Neurosurgery

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OBJECTIVELipomatosis of nerve (LN) is a massive enlargement of a nerve due to abundant proliferation of adipose and fibrotic tissue within the epineurium—part of the spectrum of adipose lesions of nerves, including intra- and extraneural lipomas. LN has been frequently associated with soft-tissue and/or osseous overgrowth. Unfortunately, much confusion exists since many names have been used for LN (e.g., fibrolipomatous hamartoma, macrodystrophia lipomatosa, and so on). To better understand this condition and to evaluate its association with nerve-territory overgrowth, the authors attempted to compile the world’s literature on published LN cases.METHODSPubMed and Google Scholar databases were searched to identify published articles on LN cases, using a variety of terms. Publications in all languages were assessed. All publications with cases determined likely to be LN were read. Cases that provided clear clinicopathological and/or radiological evidence of LN were labeled as “definite” and cases that demonstrated features of LN (e.g., nerve-territory overgrowth) but lacked definite proof of nerve involvement were labeled as “probable.”RESULTSInitial screening revealed a total of 2465 papers. After exclusions, 281 publications reported cases with a definite diagnosis of LN and 120 articles reported cases with a probable diagnosis of LN. The authors identified 618 definite and 407 probable cases of LN. Sex distribution was balanced (51% female). Early diagnosis was common, with two-thirds of patients having symptoms in the 1st decade of life. The most commonly affected nerve was the median nerve (n = 391). Nerve-territory overgrowth was common (62% definite LN; 78% combined cases); overgrowth was exclusive to the territory of the affected nerve in all cases but 5.CONCLUSIONSThe authors present a comprehensive review and analysis of the literature of LN cases. One of the main findings was the nerve-territory overgrowth was associated with LN, especially when present earlier in life. The authors believe that all cases of LN associated with overgrowth can be explained on anatomical grounds, even in the few reported cases in which this is not immediately obvious.

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Macrodystrophia lipomatosa of foot involving great toe

Cited by 2 publications

References 5 publications

Macrodystrophia lipomatosa of the foot: A case report

Macrodystrophia lipomatosa of the foot: A case report

Strengthening the association of lipomatosis of nerve and nerve-territory overgrowth: a systematic review

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