Macro-micro modeling design in system-level and experiment for a micromixer

Chen, Xueye; Liu, Chong; Xu, Zheng; Liu, Junshan; Du, Liqun

doi:10.1039/c2ay25263e

Cited by 13 publications

(5 citation statements)

References 20 publications

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“…The effective control of partially mixed samples is critical in the design of a concentration gradient generator. In recent years, we have carried out a series of studies on design [14], simulation [15,16], optimization [17,18], and fabrication [19] of micromixers.…”

Section: Introductionmentioning

confidence: 99%

Design and Fabrication of Concentration‐Gradient Generators with Two and Three Inlets in Microfluidic Chips

Chen

Wang

2017

Chem Eng & Technol

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A simple and low-cost method for designing and fabricating concentrationgradient generators with two and three inlets is proposed which can generate different concentration gradients at varying flow velocities. The microchannel structure was designed in S-shape and left-right symmetry. The concentration-gradient generator was simulated based on the finite element method. The microchannels were processed on a computer numerical control (CNC) engraving and milling machine on poly(methylmethacrylate) substrate, and then two concentrationgradient generators were fabricated by hot bonding technology. The results of experiment and simulation were compared to prove the feasibility of the method. Flow velocity was an important factor for generating different concentration gradients. The concentration-gradient profiles of the generators with two and three inlets present approximately linear and quadratic curves.

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Section: Introductionmentioning

confidence: 99%

Design and Fabrication of Concentration‐Gradient Generators with Two and Three Inlets in Microfluidic Chips

Chen

Wang

2017

Chem Eng & Technol

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“…Accordingly, the active micromixer will be destined to meet some complex difficulties to overcome during multiple design, development, and production process . Compared with the active micromixer, the passive micromixer demands a much easier manufacturing condition because it does not require external energy for hydrodynamic driving control . Passive mixing behavior typically relies on diversified microchannel structural design for fluid flow guiding along the wall and distortion to obtain the desired mixing performance .…”

Section: Introductionmentioning

confidence: 99%

A novel passive micromixer with modified asymmetric lateral wall structures

Wang

Shi

Zhou

et al. 2018

Asia-Pacific J Chem Eng

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Homogeneous and rapid mixing in microfluidic devices have always been the premise requirement due to its integration with bioengineering and chemical experiments. In this work, a novel passive micromixer with modified asymmetric lateral wall structures is designed. The numerical simulation is carried out at the Reynolds number ranging from 0.1 to 100 for the novel microchannel and the ordinary "S"-shaped microchannel. The results indicate that, compared with the "S"-shaped micromixer, the novel structure exhibits superior mixing performance, which can be attributed to the increasing inertial effect and formation of secondary flow. The simulation results suggest that the novel micromixer developed here will achieve an efficient mixing performance.

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“…More complex systems may require mixing on a smaller timescale or in a more specific matter, it is a hard work to meet these requirements in order to improve the mixing efficiency [13]. We have studied the design [14,15], simulation [16,17], optimization [18,19] and fabrication [20,21] of micro-mixers. The most common technique to shorten mixing times is reducing diffusion length scales, which employs advective stirring to increase the interfacial surface area between the fluids [22].…”

Section: Introductionmentioning

confidence: 99%

A novel passive micromixer based on Koch fractal principle

Zhang

Chen

2018

J Braz. Soc. Mech. Sci. Eng.

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This paper aims at studying on the mixing performance of micromixer with Koch fractal microchannel by numerical simulation. Setting up obstacles in the microchannel is an effective way to improve the mixing efficiency, and changing the shape of the obstacle based on the fractal principle can improve the chaotic convection in the microchannel, it can make the performance of the micromixer much better. With different parameters of the fractal obstacle, the effect on the mixing efficiency of the micromixer is different. This study proofs the effect on the mixing efficiency with different heights, distances, numbers and configurations of the obstacles. The number of the obstacles and the distance between the two fractal obstacles have a significant effect on the mixing efficiency. However, the effect of the different configurations on the mixing efficiency is negligible. Comparing the effect with different parameters, with the optimal layout of the obstacles in the microchannel can be obtained based on the Koch fractal principle. With different Res, it can make the mixing efficiency of the micromixer more than 90%. Due to its outstanding mixing performance, fractal micromixer has potential application value in chemical engineering and biochemistry.

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Macro-micro modeling design in system-level and experiment for a micromixer

Cited by 13 publications

References 20 publications

Design and Fabrication of Concentration‐Gradient Generators with Two and Three Inlets in Microfluidic Chips

Design and Fabrication of Concentration‐Gradient Generators with Two and Three Inlets in Microfluidic Chips

A novel passive micromixer with modified asymmetric lateral wall structures

A novel passive micromixer based on Koch fractal principle

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